Alexandra Crowe 1 protocol

Jonathan Miller 1 protocol

Alexandra Crowe Clinical Pharmacology, Allergan,2019
1 protocol

Wei Yue
  • Faculty, Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, US
Research focus
  • Pharmaceutical Sciences
  • 2 Author merit


Ph.D., Peking Union Medical College , China, 2001

• Crowe, A., Zheng, W., Miller, J., Pahwa, S., Alam, K., Fung, K. M., Rubin, E., Yin, F., Ding, K. and Yue, W. (2019). Characterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transporting Polypeptide (OATP) 1B1 c.521 T>C Nonsynonymous Single-Nucleotide Polymorphism. Pharm Res 36(7): 101.
• Alam, K., Farasyn, T., Ding, K. and Yue, W. (2018). Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues. Drug Metab Lett 12(1): 24-32.
• Alam, K., Farasyn, T., Crowe, A., Ding, K. and Yue, W. (2017). Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner. PLoS One 12(11): e0186924.
• Alam, K., Pahwa, S., Wang, X., Zhang, P., Ding, K., Abuznait, A. H., Li, L. and Yue, W. (2016). Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Mol Pharm 13(3): 839-851.
• Powell, J., Farasyn, T., Kock, K., Meng, X., Pahwa, S., Brouwer, K. L. and Yue, W. (2014). Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation. Drug Metab Dispos 42(11): 1964-1970.
• Yang, K., Pfeifer, N. D., Hardwick, R. N., Yue, W., Stewart, P. W. and Brouwer, K. L. (2014). An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown. Mol Pharm 11(3): 766-775.
2 Protocols published
Semi-quantitative Determination of Protein Expression Using Immunohistochemistry Staining and Analysis: An Integrated Protocol
Authors:  Alexandra R Crowe and Wei Yue, date: 12/20/2019, view: 5617, Q&A: 0
Semi-quantitative IHC is a powerful method for investigating protein expression and localization within tissues. The semi-quantitative immunohistochemistry (IHC) involves using software such as free software ImageJ Fiji to conduct deconvolution and ...
Genotyping of the OATP1B1 c. 521 T>C Polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens: An Optimized Protocol
Authors:  Alexandra R Crowe, Jonathan Miller and Wei Yue, date: 08/20/2019, view: 2281, Q&A: 0
Organic anion transporting polypeptide (OATP) 1B1 is a liver-specific transport protein that plays an important role in hepatic drug disposition. It transports many drugs from the blood into the liver, including lipid-lowering statins. The c. 521 ...
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