Marcelo Santos da Silva
  • Post-Doc, Butantan Institute
Research focus
  • Microbiology
  • DNA replication, Telomeres, Cell cycle, Trypanosomatids, Parasitology


PhD, University of Campinas (UNICAMP), 2014

Lab information

Maria Carolina Elias Lab


. DA SILVA M. S., HOVEL-MINER, G., BRIGGS, E., ELIAS, M. C., & MCCULLOCH, R. (2018) Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes. PLoS Pathogens (in press).
. ALVES, C.L*., REPOLÊS, B. M.*, DA SILVA, M. S.*, MENDES, I. C., et al., (2018) The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi. Scientific Reports, 8(1):13335. DOI: 10.1038/s41598-018-31541-z. (*co-first authors).
. SILVA, M. A., LOPES, D., TEIXEIRA, S. C., GIMENES, S., AZEVEDO, F. V. P. V., POLLONI, L., BORGES, B. C., DA SILVA, M.S., et al., (2018) Genotoxic effects of BnSP-6, a Lys-49 phospholipase A2 (PLA2) homologue from Bothrops pauloensis snake venom, on MDA-MB-231 breast cancer cells. International Journal of Biological Macromolecules, 118(Pt A):311-319. DOI: 10.1016/j.ijbiomac.2018.06.082.
. MARIN, P. A., DA SILVA, M. S., PAVANI, R. S., MACHADO, C. R., & ELIAS, M. C. (2018). Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment. Scientific reports, 8(1), 5405. DOI: 10.1038/s41598-018-23731-6.
. DA SILVA, M. S., PAVANI, R. S., DAMASCENO J.D. et al., (2017) Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems. Trends in Parasitology, 33(11):858-874. DOI: 10.1016/
. MOREA, E. G. O., VIVIESCAS, M. A., FERNANDES, C. A. H., MATIOLI, F. F., LIRA, C. B. B., FERNANDEZ, M. F., MORAES, B. S., DA SILVA, M. S., et al., (2017) A calmodulin-like protein (LCALA) is a new Leishmania amazonesis candidate for telomere end-binding protein. Biochimica et Biophysica Acta (BBA) -General Subjects, 1861, 2583–97. DOI: 10.1016/j.bbagen.2017.08.011.
. DA SILVA, M. S., MUÑOZ, P. A. M., ARMELIN, H. A., and ELIAS, M. C. (2017). Differences in the Detection of BrdU/EdU Incorporation Assays Alter the Calculation for G1, S, and G2 Phases of the Cell Cycle in Trypanosomatids. Journal of Eukaryotic Microbiology. DOI: 10.1111/jeu.12408.
. TEIXEIRA, S. C., LOPES, D. S., GIMENES, S. N., TEIXEIRA, T. L., DA SILVA, M. S. et al., (2017) Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy. Scientific Reports, 7,44978. DOI: 10.1038/srep44978.
. DA SILVA, M. S., SEGATTO, M., PAVANI, R. S., et al., (2017) Consequences of acute oxidative stress in Leishmania amazonensis: From telomere shortening to the selection of the fittest parasites. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1864(1), 138-150. DOI: 10.1016/j.bbamcr.2016.11.001.
. DA SILVA, M.S. and CANO, M.I.N., ed. (2017) Molecular and Cellular Biology of Pathogenic Trypanosomatids, Frontiers in Parasitology, 1st edition. Bentham Science Publishers. DOI: 10.2174/97816810840531170101.
. DA SILVA, M. S.; VIVIESCAS, M. A.; PAVANI, R. S. et al., (2017) Nuclear and Kinetoplast DNA Replication in Trypanosomatids In: Molecular and Cellular Biology of Pathogenic Trypanosomatids.1 ed., Bentham e-books, v.1, p. 134-194.
. CALDERANO, S. G.; MORETTI, N. S.; ARAUJO, C. B., DA SILVA, M. S. et al., (2017) The Cellular Organization of Trypanosomatids During Life Cycle In: Molecular and Cellular Biology of Pathogenic Trypanosomatids. 1 ed., Bentham e-books, v.1, p. 3-60.
. PAVANI, R. S., DA SILVA, M. S., FERNANDES, C. A. H. et al., (2016) Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi. PLoS Neglected Tropical Diseases, 10, e0005181. DOI: 10.1371/journal.pntd.0005181.
. GIRARD, R. M.; CRISPIM, M.; STOLIĆ, I.; DAMASCENO, F. S.; DA SILVA, M. S. et al., (2016) An Aromatic Diamidine That Targets Kinetoplast DNA, Impairs the Cell Cycle in Trypanosoma cruzi, and Diminishes Trypomastigote Release from Infected Mammalian Host Cells. Antimicrobial Agents and Chemotherapy, 60(10), 5867-5877. DOI: 10.1128/AAC.01595-15.
. VASCONCELOS, E. J. R.; NUNES, V. S.; DA SILVA, M. S. et al., (2014) The Putative Leishmania Telomerase RNA (LeishTER) Undergoes Trans-Splicing and Contains a Conserved Template Sequence. Plos One, v9, e112061. DOI: 10.1371/journal.pone.0112061.
. GIARDINI, M.A., SEGATTO, M., DA SILVA, M.S., et al., (2014) Telomere and telomerase biology. In: Progress in Molecular Biology and Translational Science, 1ed., Elsevier, 125:1-40. DOI: 10.1016/B978-0-12-397898-1.00001-3.
. DA SILVA, M.S., MONTEIRO, J.P., NUNES, V.S., et al., (2013) Leishmania amazonensis promastigotes present two distinct modes of nucleus and kinetoplast segregation during cell cycle. PLoS One. 8(11), e81397. DOI: 10.1371/journal.pone.0081397.
. DA SILVEIRA, R.C.V.*, DA SILVA, M.S.*, NUNES, V.S., et al. (2013) The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection. Parasitology, 140, 547–559. DOI: 10.1017/S0031182012002028. (*co-first authors)
. DA SILVA, M. S.; da SILVEIRA, R. C. V. ; PEREZ, A. M., et al., (2012) Nuclear DNA Replication in Trypanosomatid Protozoa. In: DNA Replication and Mutation. 1ed. Nova Science Publishers, 1:123-178.
. DA SILVA, M.S., PEREZ, A.M., DA SILVEIRA, R.C.V., et al., (2010) The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres. BMC Microbiology, 10:136. DOI: 10.1186/1471-2180-10-136.
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