Aruna Bitra
  • Post-Doc, La Jolla institute for allergy and immunology
Research focus
  • Biochemistry
  • Protein-protein interactions,
    Structural Biology
    Protein Biochemistry

Lab information

Dr. Dirk Zajonc Lab


[1] Bitra A., Hussain B.,Tanwar A S. and Anand R., “Identification of Function and Mechanistic Insights of Guanine Deaminase from Nitrosomonas europaea: Role of the C-Terminal Loop in Catalysis”, Biochemistry, 52, (2013), 3512-3522.
[2] Bitra A., Biswas A. and Anand R., “Structural Basis of Substrate Specificity of CDA Superfamily Guanine Deaminase”, Biochemistry, 52, (2013), 8106-8114).
[3] Kotha S#., Goyal D*., Bitra A*., Thota N., Kruger G. and Anand R., “Diversity Oriented Approach to Triazole Based Peptidomimetics as Mammalian Sterile 20 Kinase Inhibitors”, Rsc advances, 3, (2013), 24447-24454 (#Corresponding author, *Both authors contributed equally towards this work)
[4] Hussain B., Ruchika B., Bitra A., Anand R., “Structural and functional basis of transcriptional regulation by TetR family proteinCprB from S. coelicolor A3(2)”, Nucleic Acids Research, (2014).
[5] Bitra A., Sistla S., Mariam J., Malvi H. and Anand R., “Rassf proteins as modulators of Mst1 kinase activity”, Nature Scientific Reports, (2017), 45020.
[6] Bitra, A., Doukov, T., Wang, J., Picarda, G., Benedict, C. A., Croft, M., and Zajonc, D. M., “Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling” Journal of Biological Chemistry, (2017).
[7] Madireddi, S., Eun, S.-Y., Mehta, A. K., Bitra, A., Zajonc, D. M., Niki, T., Hirashima, M., Podack, E. R., Schreiber, T. H., and Croft, M., “Regulatory T Cell–Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9”, The Journal of Immunology (2017).
[8] Matho, M. H., Schlossman, A., Gilchuk, I. M., Miller, G., Mikulski, Z., Hupfer, M., Wang, J., Bitra, A., Meng, X., Xiang, Y., Kaever, T., Doukov, T., Ley, K., Crotty, S., Peters, B., Hsieh-Wilson, L. C., Crowe, J. E., and Zajonc, D. M., “Structure–function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8” (2018) Journal of Biological Chemistry, 293, 390-401
[9] Bitra, A., Doukov, T., Croft, M., and Zajonc, D. M., “Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier” Journal of Biological Chemistry, (2018).
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.