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Reviewer
Aruna Bitra
  • Post-Doc, La Jolla institute for allergy and immunology
Research focus
  • Biochemistry
  • Protein-protein interactions,
    Structural Biology
    Protein Biochemistry

Lab information

Dr. Dirk Zajonc Lab

Publications

[1] Bitra A., Hussain B.,Tanwar A S. and Anand R., “Identification of Function and Mechanistic Insights of Guanine Deaminase from Nitrosomonas europaea: Role of the C-Terminal Loop in Catalysis”, Biochemistry, 52, (2013), 3512-3522.
[2] Bitra A., Biswas A. and Anand R., “Structural Basis of Substrate Specificity of CDA Superfamily Guanine Deaminase”, Biochemistry, 52, (2013), 8106-8114).
[3] Kotha S#., Goyal D*., Bitra A*., Thota N., Kruger G. and Anand R., “Diversity Oriented Approach to Triazole Based Peptidomimetics as Mammalian Sterile 20 Kinase Inhibitors”, Rsc advances, 3, (2013), 24447-24454 (#Corresponding author, *Both authors contributed equally towards this work)
[4] Hussain B., Ruchika B., Bitra A., Anand R., “Structural and functional basis of transcriptional regulation by TetR family proteinCprB from S. coelicolor A3(2)”, Nucleic Acids Research, (2014).
[5] Bitra A., Sistla S., Mariam J., Malvi H. and Anand R., “Rassf proteins as modulators of Mst1 kinase activity”, Nature Scientific Reports, (2017), 45020.
[6] Bitra, A., Doukov, T., Wang, J., Picarda, G., Benedict, C. A., Croft, M., and Zajonc, D. M., “Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling” Journal of Biological Chemistry, (2017).
[7] Madireddi, S., Eun, S.-Y., Mehta, A. K., Bitra, A., Zajonc, D. M., Niki, T., Hirashima, M., Podack, E. R., Schreiber, T. H., and Croft, M., “Regulatory T Cell–Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9”, The Journal of Immunology (2017).
[8] Matho, M. H., Schlossman, A., Gilchuk, I. M., Miller, G., Mikulski, Z., Hupfer, M., Wang, J., Bitra, A., Meng, X., Xiang, Y., Kaever, T., Doukov, T., Ley, K., Crotty, S., Peters, B., Hsieh-Wilson, L. C., Crowe, J. E., and Zajonc, D. M., “Structure–function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8” (2018) Journal of Biological Chemistry, 293, 390-401
[9] Bitra, A., Doukov, T., Croft, M., and Zajonc, D. M., “Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier” Journal of Biological Chemistry, (2018).