Corinne Cayrol Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS, Université de Toulouse UPS, France, France,
1 protocol

Emilie Mirey Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS, Université de Toulouse UPS, France, France,
1 protocol

Anaïs Duval Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS, Université de Toulouse UPS, France, France,
1 protocol

Pauline Schmitt Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS, Université de Toulouse UPS, France, France,
1 protocol

Jean-Philippe Girard
  • Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS, Université de Toulouse UPS, France, France,
  • 1 Author merit

Education

PhD in Molecular Biology , University of Toulouse , France, 1992

Current position

1st Class Senior Research Director (DR1) at INSERM, Director of the Institute of Pharmacology and Structural Biology (IPBS), CNRS and University of Toulouse , France

Publications

  1. Cayrol, C., Duval, A., Schmitt, P., Roga, S., Camus, M., Stella, A., Burlet-Schiltz, O., Gonzalez-de-Peredo, A. and Girard, J.-P. (2018). Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33. Nature Immunology 19(4): 375-385. 

  2. Liew, F. Y., Girard, J. P. and Turnquist, H. R. (2016). Interleukin-33 in health and disease. Nat Rev Immunol 16(11): 676-689. 

  3. Lefrancais, E., Duval, A., Mirey, E., Roga, S., Espinosa, E., Cayrol, C. and Girard, J. P. (2014). Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc Natl Acad Sci U S A 111(43): 15502-15507. 

  4. Cayrol, C. and Girard, J. P. (2014). IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. Curr Opin Immunol 31: 31-37. 

  5. Lefrancais, E., Roga, S., Gautier, V., Gonzalez-de-Peredo, A., Monsarrat, B., Girard, J. P. and Cayrol, C. (2012). IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A 109(5): 1673-1678. 

  6. Girard, J. P., Moussion, C. and Forster, R. (2012). HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol 12(11): 762-773. 

  7. Moussion, C. and Girard, J. P. (2011). Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature 479(7374): 542-546. 

  8. Cayrol, C. and Girard, J. P. (2009). The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A 106(22): 9021-9026. 

  9. Moussion, C., Ortega, N. and Girard, J. P. (2008). The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One 3(10): e3331. 

  10. Carriere, V., Roussel, L., Ortega, N., Lacorre, D. A., Americh, L., Aguilar, L., Bouche, G. and Girard, J. P. (2007). IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A 104(1): 282-287.

1 Protocol published
Isolation and Culture of Mouse Lung ILC2s
Authors:  Pauline Schmitt, Anais Duval, Emilie Mirey, Jean-Philippe Girard and Corinne Cayrol, date: 10/05/2018, view: 390, Q&A: 0
Group 2 Innate Lymphoid Cells (ILC2) play an important role in immune responses at barrier surfaces, notably in the lung during airway allergic inflammation or asthma. Several studies have described methods to isolate ILC2s from wild-type naive ...
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