Atta Ahmad
  • Asst Prof Teaching, East Carolina University
Research focus
  • Biochemistry
  • Protein Aggregation, Protein folding, Chaperones, Drug Design
  • 1 Author merit

Education

Ph.D., Central Drug Research Institute, 2001

Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=atta+ahmad
• Zuiderweg ERP, Taylor IR, Ahmad A, Nordhues BA, Bhullar A and Gestwicki JE (2018) The disorderly conduct of Hsc70 and its interaction with the Alzheimer’s related Tau protein J Biol Chem. 293(27):10796-10809
• Ahmad A*, Farwell M, Muzaffar M. (2017) Identifying Molecular Chaperones As Therapeutic Targets For Cancer - A Mini Review. Biochemistry and Pharmacology (Los Angel) 6:224
• Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki JE, Cuervo AM, Zuiderweg ER, Santambrogio L. (2016) Hsc-70 Structural and Biological Interaction with Phosphatidylserine in Endosomal Microautophagy. J Biol Chem. 291, 18096-106
• Ahmad A*, Muzaffar M (2016) Molecular Chaperones and Co-chaperones as Therapeutic Targets for Cancer. J Mol Pharm Org Process Res. 4:e124 [doi: 10.4172/2329-9053.1000e124]
• Ahmad A*, Stratton CM, Scemama JL, Muzaffar M. (2016) Effect of Ca2+ on Aß40 fibrillation is characteristically different. Int J Biol Macromol. 89, 297-304
• Li X, Srinivasan S, Connarn J, Ahmad A, Young Z, Kabza A, Zuiderweg E, Sun D, Gestwicki JE. (2013) Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077 as Anti-Cancer Agents. ACS Med Chem Lett 4, 1042-47
• Cesa LC, Patury S, Komiyama T, Ahmad A, Zuiderweg ER and Gestwicki JE. (2013) Inhibitors of Difficult Protein-Protein Interactions Identified by High-Throughput Screening of Multiprotein Complexes. ACS Chem 8, 1988-97
• Zuiderweg ERP, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki JE and Ahmad A (2013) Allostery in the Hsp70 chaperone proteins. Top Curr Chem 328, 99-153
• Ahmad A*, Burns CS, Fink AL and Uversky VN (2012) Peculiarities of copper binding to a-synuclein. Journal of Biomol Struct Dyn 29, 825-842
• Zuiderweg ERP and Ahmad A (2012) Evaluation of competing J domain: Hsp70 Complex Models in light of methods used. Proc Natl Acad Sci USA 109, E735
• Ahmad A, Bhattacharya A, McDonald RA, Cordes M, Ellington B, Bertelsen EB and Zuiderweg ERP (2011) The Hsp70 chaperone/DnaJ co-chaperone complex employs an unusual dynamical interface. Proc Natl Acad Sci USA 108, 18966-18971
• Muzaffar M and Ahmad A* (2011) The Mechanism of Enhanced Insulin Amyloid Fibril Formation by NaCl Is Better Explained by a Conformational Change Model. PLoS ONE 6(11): e27906
• Ahmad A* (2010) DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease. Int J Biol Macromol. 46, 275-279.
• Ahmad A*, Muzaffar M and Ingram VM (2009) Ca2+, within the physiological concentrations, selectively accelerates Aβ42 fibril formation and not Aβ40 in vitro. Biochim. Biophys. Acta. 1794, 1536-1547.
• Munishkina LA, Ahmad A, Fink AL and Uversky VN (2008) Guiding protein aggregation by molecular crowding. Biochemistry 47, 8993-9006.
• Hood EE, Love R, Lane J, Bray J, Clough R, Pappu K, Drees C, Hood KR, Yoon S, Ahmad A, Howard JA (2007) Subcellular targeting is a key condition for high-level accumulation of cellulase protein in transgenic maize seed. Plant Biotechnol J. 5, 709-19.
• Hong DP, Ahmad A and Fink AL (2006) Fibrillation of human insulin A and B chain. Biochemistry 45, 9342-9353.
• Ahmad A, Uversky VN, Hong D and Fink AL (2005) Early events in insulin monomer fibrillation J Biol. Chem. 280, 42669-42675.
• Ahmad A, Millet IS, Doniach S, Uversky VN and Fink AL (2004) Stimulation of insulin fibrillation by urea-induced intermediates. J Biol. Chem. 279, 14999-13.
• Ahmad A, Millet IS, Doniach S, Uversky VN and Fink AL (2003) Partially Folded Intermediates in Insulin Fibrillation. Biochemistry 42, 11404-11416.
• Akhtar MS, Ahmad A, and Bhakuni V (2002) Guanidinium chloride and urea induced unfolding of dimeric enzyme glucose oxidase. Biochemistry 41, 3819-3827.
• •Akhtar MS, Ahmad A and Bhakuni V (2002) Divalent cation induced changes in structural properties of the dimeric enzyme glucose oxidase: Dual effect of dimer dissociation with loss of cooperative interactions in enzyme monomer. Biochemistry 41, 7142-7149.
• Ahmad A, Akhtar MS and Bhakuni V (2001) Monovalent Cation Induced Conformational Change in Glucose Oxidase Leading to Stabilization of Enzyme. Biochemistry 40, 1945-1955.
• Ahmad A, Madhusudanan KP and Bhakuni V (2000) Trichloroacetic Acid and Trifluoroacetic Acid Induced Unfolding of Cytochrome c: Stabilization of a Native like Folded Intermediate. Biochim. Biophys. Acta. 1480, 201-210.
• Ali V, Prakash K, Kulkarni S, Ahmad A, Madhusudanan KP and Bhakuni V (1999) 8-Anilino-1-Napthalenesulfonic Acid Induces Folding of Acid Unfolded Cytochrome c to Molten Globule State as a Result of Electrostatic Interactions. Biochemistry 38, 13635-13642.
1 Protocol published
Modifications in the Transformation Step of Commercially Available Site-directed Mutagenesis Kit Increase Its Price-performance
Site-directed mutagenesis helps unravel the relationship between the structure and function of a protein at the level of amino acid contributions. Many techniques have been established to carry out site-directed mutagenesis on a daily routine. ...
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