Jesús Ciriza
  • Research scientist, NanoBiocel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Spain, Spain,
Research focus
  • Stem cell
  • 1 Author merit


PhD, University of Zaragoza, Spain, 2004

Current position

Researcher, CIBER, CIBER, Spain


  1. Cañibano-Hernández A, Saenz Del Burgo L, Espona-Noguera A, Orive G, Hernandez RM, Ciriza J, Pedraz JL.Hyaluronic acid promotes differentiation of mesenchymal stem cells from different sources towards pancreatic progenitors within 3D alginate matrices. Mol Pharm. 2019 Jan 2. doi: 10.1021/acs.molpharmaceut.8b01126. [Epub ahead of print]. Correspoding author.
  2. Cañibano-Hernández A, Burgo LSD, Espona-Noguera A, Orive G, Hernández RM, Ciriza J, Pedraz JL. Hyaluronic acid enhances cell survival of encapsulated insulin-producing cells in alginate-based microcapsules. Int J Pharm. 557 (2019) 192–198. Correspoding author.
  3. Gurruchaga H, Saenz Del Burgo L, Orive G, Hernandez RM, Ciriza J, Pedraz JL. Low molecular-weight hyaluronan as a cryoprotectant for the storage of microencapsulated cells. Int J Pharm. 548 (2018) 206–216. Correspoding author.
  4. Laura Saenz del Burgo, Jesús Ciriza, Albert Espona-Noguera, Xavi Illa, Enric Cabruja, Gorka Orive, Rosa María Hernández, Rosa Villa, Jose Luis Pedraz & Mar Alvarez 3D Printed porous polyamide macrocapsule combined with alginate microcapsules for safer cell-based therapies. Scientific Reports (2018) 8:8512
  5. Gurruchaga H , Saenz del Burgo L , Hernandez R.M , Orive G , Selden C , Fuller B , Ciriza J , Pedraz J.L. Advances in the slow freezing cryopreservation of microencapsulated cells Journal of Controlled Release 281 (2018) 119–138. Correspoding author. 
  6. Jesús Ciriza, Laura Saenz del Burgo, Haritz Gurruchaga, Francesc E. Borras, Marcella Franquesa, Gorka Orive, Rosa Maria Hernández & José Luis Pedraz Graphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response. Drug Delivery, 2018, 25,(1): 1147-1160. Correspoding author.
  7. Cañibano-Hernández A,Del Burgo LS,Espona-Noguera A, Ciriza J, Pedraz JL. Current advanced therapy cell-based medicinal products for type-1-diabetes treatment. Int J Pharm. 2018 Mar 27;543(1-2):107-120. Correspoding author.
  8. Sola A, Saenz Del Burgo L, Ciriza J, Hernandez RM, Orive G, Martin Cordero J, Calle P, Pedraz JL, Hotter G. Microencapsulated macrophages releases conditioned medium able to prevent epithelial to mesenchymal transition. Drug Deliv. 2018 Nov;25(1):91-101. doi: 10.1080/10717544.2017.1413449.
  9. Gurruchaga H, Saenz Del Burgo L, Garate A, Delgado D, Sanchez P, Orive G, Ciriza J, Sanchez M, Pedraz JL. Cryopreservation of Human Mesenchymal Stem Cells in an Allogeneic Bioscaffold based on Platelet Rich Plasma and Synovial Fluid. Sci Rep. 2017 Nov 16;7(1):15733. doi: 10.1038/s41598-017-16134-6. Correspoding author.
  10. Espona-Noguera A, Ciriza J, Cañibano-Hernández A, Fernandez L, Ochoa I, Del Burgo LS, Pedraz JL. Tunable injectable alginate-based hydrogel for cell therapy in Type 1 Diabetes Mellitus. Int J Biol Macromol. 2017 Sep 26. pii: S0141-8130(17)32503-5. doi: 10.1016/j.ijbiomac.2017.09.103. [Epub ahead of print]
  11. Cañibano-Hernández A, Saenz Del Burgo L, Espona-Noguera A, Orive G, Hernández RM, Ciriza J, Pedraz JL.Alginate Microcapsules Incorporating Hyaluronic Acid Recreate Closer in Vivo Environment for Mesenchymal Stem Cells.Mol Pharm. 2017. doi: 10.1021/acs.molpharmaceut.7b00295. Correspoding author.
  12. Acarregui A, Ciriza J, Saenz Del Burgo L, Gurruchaga Iribar H, Yeste J, Illa X, Orive G, Hernández RM, Villa R, Pedraz JL Characterization of an encapsulated insulin secreting human pancreatic beta cell line in a modular microfluidic device.J Drug Target. 2017. doi: 10.1080/1061186X.2017.1334208.
  13. Saenz del Burgo, Laura; Ciriza, Jesús; Acarregui, Argia; Gurruchaga, Haritz; Blanco, Francisco; Orive, Gorka; Hernandez, Rosa; Pedraz, José Luis.Hybrid Alginate-protein-coated Graphene Oxide Microcapsules Enhance the Functionality of Erythropoietin Secreting C2C12 Myoblasts. Molecular Pharmaceutics 14(3):885-898. 2017
  14. Megías R, Arco M, Ciriza J, Burgo LS, Puras G, López-Viota M, Delgado ÁV, Dobson JP, Arias JL, Pedraz JL. Design and characterization of a magnetite/PEI multifunctional nanohybrid as non-viral vector and cell isolation system. Int J Pharm. 2017 Feb 25;518(1-2):270-280.
  15. Ane Garate, Jesus Ciriza, Javier G. Casado, Rebeca Blazquez, Jose Luis Pedraz, Gorka Orive and Rosa Hernandez. Assesment of hte Behavior of Mesenchymal Stem Cells Immobilized in Biomimetic Alginate Microcapsules. Molecular Pharmaceutics (2017) 1479:207-216.
  16. J. Ciriza, Saenz del Burgo L, M. Virumbrales-Muñoz, I. Ochoa, L.J. Fernandez, G. Orive, R.M. Hernandez, J.L. Pedraz Graphene oxide increases the viability of C2C12 myoblasts microencapsulated in alginate International Journal of Pharmaceutics 493 (2015) 260–270
  17. Haritz Gurruchaga, Jesús Ciriza, Laura Saenz del Burgo, Juan Roberto Rodriguez-Madoz, Edorta Santos, Felipe Prosper, Rosa María Hernández, Gorka Orive, Jose Luis Pedraz. Cryopreservation of microencapsulated murine mesenchymal stem cells genetically engineered to secrete erythropoietin. International Journal of Pharmaceutics 485: 15-24 2015
  18. Jesús Ciriza, Christa Caneda, Bryce McLelland and Jennifer O. Manilay. Murine CD133+CD49flow/+ Cells Derived from ESCs Differentiate into Insulin Producing Cells in vivo. Int J Stem Cell Res Ther 2015, 2:1. Corresponding author.
  19. Haritz Gurruchaga, Jesús Ciriza, Laura Saenz del Burgo, Juan Roberto Rodriguez-Madoz, Edorta Santos, Felipe Prosper, Rosa María Hernández, Gorka Orive, Jose Luis Pedraz. Cryopreservation of microencapsulated murine mesenchymal stem cells genetically engineered to secrete erythropoietin. International Journal of Pharmaceutics 485: 15-24
  20. Haritz Gurruchaga, Laura Saenz del Burgo, Jesús Ciriza, Gorka Orive, Rosa María Hernández, Jose Luis Pedraz. Advances in cell encapsulation technology and its application in drug delivery. Expert Opinion on Drug Delivery, Vol 12, 1-17. 2015
  21. Haritz Gurruchaga, Laura Saenz del Burgo, Jesus Ciriza, Rosa Maria Hernandez, Gorka Orive, Jose Luis Pedraz. Nanoteknologiaren aplikazioak garun-minbizian. EKAIA, 27, 2015.
  22. Jesús Ciriza, Heather Thompson, Raffi Petrosian, Jennifer O. Manilay, Marcos E. García-Ojeda. The migration of Hematopoietic Progenitors from the Fetal Liver to the Fetal Bone Marrow: Lessons Learned and Possible Clinical Applications. Exp Hematol. 2013 May;41(5):411-23 doi: 10.1016/j.exphem.2013.01.009. Epub 2013 Feb 6.
  23. Jesús Ciriza, Dominique Hall, Alison Lu, Joseph Robert De Sena, Mufadhal Al-Kuhlani, Marcos E. García-Ojeda. Single-cell multiplex RT- Single-cell analysis of murine long-term hematopoietic stem cells reveals distinct patterns of gene expression during fetal migration PLoS One. 2012;7(1):e30542. Epub 2012 Jan 20.
  24. María Moreno-Igoa, Ana Cristina Calvo, Jesús Ciriza, María Jesús Muñoz, Pilar Zaragoza and Rosario Osta. Non-viral gene delivery of the GDNF, either alone or fused to the C-fragment of tetanus toxin protein, prolongs survival in a mouse ALS model. Restor Neurol Neurosci., 30(1):69-80. 2012
  25. Luna JI, Ciriza J, Garcia-Ojeda ME, Kong M, Herren A, Lieu DK, Li R, Fowlkes CC, Khine M, McCloskey KE. Multi-scale Biomimetic Topography for the Alignment of Neonatal and Embryonic Stem Cell-derived Heart Cells. Tissue Eng Part C Methods, (5):579-88. Epub 2011 Feb 27. Cover page of journal.
  26. Stephanie Smith-Berdan, Andrew Nguyen, Deena Hassanein, Matthew Zimmer, Fernando Ugarte, Jesús Ciriza, Dean Li, Marcos E. García-Ojeda, Lindsay Hinck, E. Camilla Forsberg. Robo4 cooperates with Cxcr4 to specify hematopoietic stem cell localization to bone marrow niches. Cell Stem Cell 8, 72–83, 2011- Cover page of journal.
  27. Ciriza J., García-Ojeda ME. Expression of Migration-Related Genes is Progressively Upregulated in Murine Lineage-Sca-1+c-Kit+ population from the Fetal to Adult Stages of Development. Stem Cell Research & Therapy 1:14, 2010.
  28. X. de Andrés, R. Reina, J. Ciriza, H. Crespo, I. Glaria, H. Ramírez, M.J. Grilló, M.M. Pérez, V. Andrésdóttir, S. Rosati, M. Suzan-Monti, L. Luján, B.A. Blacklaws, G.D. Harkiss, D. de Andrés, B. Amorena. Use of B7 costimulatory molecules as adjuvants in a prime-boost vaccination against Visna /Maedi ovine lentivirus. Vaccine 27: 4591–4600. 2009.
  29. Ciriza J, Moreno-Igoa M, Calvo AC, Yague G, Palacio J, Miana-Mena FJ; Muñoz MJ; Zaragoza P, Brûlet P y Osta R A Genetic fusion GDNF-C fragment of tetanus toxin prolongs survival in a symptomatic mouse ALS model. Restorative Neurology And Neuroscience. 26 (6):459-465. 2008
  30. Ciriza J, García-Ojeda ME, Martín-Burriel I, Agulhon C, Miana-Mena FJ, Muñoz MJ, Zaragoza P, Brûlet P, Osta R Antiapoptotic activity maintenance of Brain Derived Neurotrophic factor and the C fragment of the tetanus toxin genetic fusion protein. Central European Journal Biology. 3(2):105–112. 2008.
  31. Miana-Mena FJ, Munoz MJ, Yagüe G., Mendez M; Moreno M, Ciriza J, Zaragoza P, Osta R. Optimal methods to characterize the G93A mouse models of ALS. Amyotrophic Lateral Sclerosis Other Motor Neuron Disorder., 6(1): 55-62.2005
  32. Miana-Mena FJ, Muñoz MJ, Roux S, Ciriza J., Zaragoza P, Brûlet P, Osta R A non-viral vector targeting gene therapy to motoneuron in the CNS. Neurodegenerative Diseases,1:101-108. 2004.
  33. Miana-Mena FJ, Munoz MJ, Ciriza J, Soria J, Brulet P, Zaragoza P, Osta R. Fragment C tetanus toxin: A putative activity-dependent neuroanatomical tracer. Acta Neurobioogy. Experimental, 63: 211-218. 2003.
1 Protocol published
Cell Microencapsulation and Cryopreservation with Low Molecular Weight Hyaluronan and Dimethyl Sulfoxide
Authors:  H. Gurruchaga, L. Saenz del Burgo, G. Orive, R. M. Hernandez, J. Ciriza and J. L. Pedraz, date: 02/20/2019, view: 3490, Q&A: 0
Cryopreservation is commonly used for the storage of cells, tissues, organs or 3D cell-based products using ultra-low temperatures, which involves the immersion in liquid nitrogen for their long-term preservation. The cryopreservation of several ...
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