Ee Chen Biochemistry, National University of Singapore, Singapore, Singapore,
1 protocol

Hwei Tan Department of Biochemistry, National University of Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore,
1 protocol

Ahmed Sayed Department of Biological Sciences, National University of Singapore, Singapore, Singapore,
1 protocol

Bingbing Ren BIOCHEMISTRY, National University of Singapore, Singapore, Singapore,
1 protocol

Yu Keung Mok
  • Department of Biological Sciences, National University of Singapore, Singapore, Singapore,
  • 1 Author merit

Education

PhD, University of Cambridge, United Kingdoms, 1996

Current position

Associate Professor, Biological Sciences, National University of Singapore, Singapore

Publications (Since 2011)

  1. Ashraf, N. M., Krishnagopal, A., Hussain, A., Kastner, D., Syed, A. M. M, Mok, H. Y., Swaminathan, K. and Zeeshan, N. (2018). Isolation of a novel mesophilic serine endoprotease (mSP): improving its thermostability and catalytic efficiency by engineering non-catalytic residues. (Unpublished).
  2. Ren, B., Sayed, A. M. M., Tan, H. L., Mok, Y. K. and Chen, E. S. (2018). Identifying protein interaction with histone peptide using Bio-layer interferometry. (Unpublished)
  3. Tan, H. L., Lim, K. K., Yang, Q., Fan, J. S., Sayed, A. M. M., Low, L. S., Ren, B., Lim, T. K., Lin, Q., Mok, Y. K., Liou, Y. C. and Chen, E. S. (2018). Prolyl isomerization of the CENP-A N-terminus regulates centromeric integrity in fission yeast. Nucleic Acids Res 46(3): 1167-1179. 

  4. Ren, B., Tan, H. L., Nguyen, T. T. T., Sayed, A. M. M., Li, Y., Mok, Y. K., Yang, H. and Chen, E. S. (2018). Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast. Nucleic Acids Res 46(1): 189-202. 

  5. Ramesh, K., Lama, D., Tan, K. W., Nguyen, V. S., Chew, F. T., Verma, C. S. and Mok, Y. K. (2018). Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity. Structure 26(9): 1178-1186.e1173. 

  6. Nguyen, V. S., Tan, K. W., Ramesh, K., Chew, F. T. and Mok, Y. K. (2017). Structural basis for the bacterial membrane insertion of dermcidin peptide, DCD-1L. Sci Rep 7(1): 13923. 

  7. Nguyen, V. S., Loh, X. Y., Wijaya, H., Wang, J., Lin, Q., Lam, Y., Wong, W. S. and Mok, Y. K. (2015). Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-kappaB p50. J Nat Prod 78(2): 208-217. 

  8. Nguyen, V. S., Jobichen, C., Tan, K. W., Tan, Y. W., Chan, S. L., Ramesh, K., Yuan, Y., Hong, Y., Seetharaman, J., Leung, K. Y., Sivaraman, J. and Mok, Y. K. (2015). Structure of AcrH-AopB Chaperone-Translocator Complex Reveals a Role for Membrane Hairpins in Type III Secretion System Translocon Assembly. Structure 23(11): 2022-2031. 

  9. Wang, J., Tan, X. F., Nguyen, V. S., Yang, P., Zhou, J., Gao, M., Li, Z., Lim, T. K., He, Y., Ong, C. S., Lay, Y., Zhang, J., Zhu, G., Lai, S. L., Ghosh, D., Mok, Y. K., Shen, H. M. and Lin, Q. (2014). A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis. Mol Cell Proteomics 13(3): 876-886. 

  10. Offermann, L. R., Chan, S. L., Osinski, T., Tan, Y. W., Chew, F. T., Sivaraman, J., Mok, Y. K., Minor, W. and Chruszcz, M. (2014). The major cockroach allergen Bla g 4 binds tyramine and octopamine. Mol Immunol 60(1): 86-94. 

  11. Hu, W., Anand, G., Sivaraman, J., Leung, K. Y. and Mok, Y. K. (2014). A disordered region in the EvpP protein from the type VI secretion system of Edwardsiella tarda is essential for EvpC binding. PLoS One 9(11): e110810. 

  12. Padavannil, A., Jobichen, C., Mills, E., Velazquez-Campoy, A., Li, M., Leung, K. Y., Mok, Y. K., Rosenshine, I. and Sivaraman, J. (2013). Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes. Nat Commun 4: 2546. 

  13. Tan, K. W., Ong, T. C., Gao, Y. F., Tiong, Y. S., Wong, K. N., Chew, F. T. and Mok, Y. K. (2012). NMR structure and IgE epitopes of Blo t 21, a major dust mite allergen from Blomia tropicalis. J Biol Chem 287(41): 34776-34785. 

  14. Tan, K. W., Jobichen, C., Ong, T. C., Gao, Y. F., Tiong, Y. S., Wong, K. N., Chew, F. T., Sivaraman, J. and Mok, Y. K. (2012). Crystal Structure of Der f 7, a Dust Mite Allergen from Dermatophagoides farinae. PLOS ONE 7(9): e44850.

  15. Leung, K. Y., Siame, B. A., Tenkink, B. J., Noort, R. J. and Mok, Y. K. (2012). Edwardsiella tarda - virulence mechanisms of an emerging gastroenteritis pathogen. Microbes Infect 14(1): 26-34. 

  16. Tan, K. W., Kumar, S., Chew, F. T. and Mok, Y. K. (2011). Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of a major group 7 allergen, Der f 7, from the dust mite Dermatophagoides farinae. Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 12): 1612-1615. 

  17. Chen, Y. W., Mok, H. Y., Wong, K. B., Tang, K., Yiu, B. and Yu, G. (2011). Strong, non-local interactions: the Hong Kong bond. Protein Eng Des Sel 24(1-2): 235-239. 

  18. Chatterjee, C., Kumar, S., Chakraborty, S., Tan, Y. W., Leung, K. Y., Sivaraman, J. and Mok, Y. K. (2011). Crystal structure of the heteromolecular chaperone, AscE-AscG, from the type III secretion system in Aeromonas hydrophila. PLoS One 6(4): e19208. 

  19. Chakraborty, S., Sivaraman, J., Leung, K. Y. and Mok, Y. K. (2011). Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda. J Biol Chem 286(45): 39417-39430. 

  20. Bernardo Paul, H., Sivaraman, T., Wan, K.-F., Xu, J., Krishnamoorthy, J., Song Chun, M., Tian, L., Chin Jasmine, S. F., Lim Diane, S. W., Mok Henry, Y. K., Yu Victor, C., Tong Joo, C. and Chai Christina, L. L. (2011). Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1. Pure and Applied Chemistry. 83: 723.



1 Protocol published
Identifying Protein Interactions with Histone Peptides Using Bio-layer Interferometry
Authors:  Bingbing Ren, Ahmed Mahmoud Mohammed Sayed, Hwei Ling Tan, Yu Keung Mok and Ee Sin Chen, date: 09/20/2018, view: 612, Q&A: 0
Histone post-translational modifications (PTMs) regulate numerous cellular processes, including gene transcription, cell division, and DNA damage repair. Most histone PTMs affect the recruitment or exclusion of reader proteins from chromatin. Here, ...
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