Ana Santos Almeida University College Cork
5 protocols

Chiara Ambrogio Dana Farber Cancer Institute
17 protocols

Reviewer
Raquel Santana da Cruz
  • Post-Doc, Georgetown University
Research focus
  • Cancer biology
  • Ancestral obesity and offspring pancreatic cancer risk
    Paternal diet programs breast cancer in female offspring

Education

PhD, University of Sao Paulo, 2016

Lab information

The research in our lab focuses on non-genetic inheritance of cancer predisposition. Each parent contributes half of their genome to their offspring, but at conception they also transmit a molecular memory of past environmental experiences to their progeny through epigenetic mechanisms. This epigenetic memory, stored in non-coding RNAs and other molecules, can determine the fate of organs in the developing embryo and make it more or less prone to developing chronic diseases such as cancer. Through our research, we seek to understand how paternal obesity, dietary patterns, stress and exposure to environmental toxicants before conception can modulate the risk for cancer in the next generation, including cancers of the breast and pancreas as well as neuroblastoma. We use animal models, in vitro systems, human cohorts, and molecular biology techniques to answer our questions.

Publications

da Cruz et al. Breast Cancer Research (2018) 20:99 https://doi.org/10.1186/s13058-018-1034-7
Fontelles CC, da Cruz RS, Hilakivi-Clarke L, de Assis S, Ong TP. Developmental Origins of Breast Cancer: A Paternal Perspective. Methods Mol Biol. 2018;1735:91-103. doi: 10.1007/978-1-4939-7614-0_5.
Fontelles CC, da Cruz RS, Hilakivi-Clarke L, de Assis S, Ong TP. Investigation
of Paternal Programming of Breast Cancer Risk in Female Offspring in Rodent Models. Methods Mol Biol. 2018;1735:207-220. doi: 10.1007/978-1-4939-7614-0_11.
R.S.M. de Miranda Torrinhas et al. / Clinical Nutrition 32 (2013) 503e510504
2 Protocols reviewed
Isolation and Quantification of Metabolite Levels in Murine Tumor Interstitial Fluid by LC/MS
Authors:  Mark R Sullivan, Caroline A Lewis and Alexander Muir, date: 11/20/2019, view: 618, Q&A: 0
Cancer is a disease characterized by altered metabolism, and there has been renewed interest in understanding the metabolism of tumors. Even though nutrient availability is a critical determinant of tumor metabolism, there has been little systematic ...
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Minigene Assay to Evaluate CRISPR/Cas9-based Excision of Intronic Mutations that Cause Aberrant Splicing in Human Cells
Authors:  David J. Sanz and Patrick T. Harrison, date: 06/05/2019, view: 855, Q&A: 0
The construction of Hybrid minigenes provides a robust and simple strategy to study the effects of disease-causing mutations on mRNA splicing when biological material from patient cells is not available. Hybrid minigenes can be used as splicing ...
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