Alexandros Kokotos Weill Cornell Medicine
18 protocols

Ashish Ranjan University of Minnesota Twin Cities
1 protocol

Fanny Ehret German Center for Neurodegenerative Diseases Dresden
5 protocols

Laxmi Narayan Mishra
  • Post-Doc, Albert Einstein College of Medicine, Bronx, New York
Research focus
  • Biochemistry
  • Linker histone H1, Histone PTMs, Nucleosome, Chromatin, Nucleosome Assembly, Chromatin Folding, Transcription


Ph.D., JNCASR, Bangalore, India, 2013

Lab information

Prof. Arthur Skoultchi's Lab

1. Sean E. Healton, Hugo D. Pinto, Laxmi N. Mishra, Gregory A. Hamilton, Justin C. Wheat, Kalina Swist-Rosowska, Nicholas Shukeir, Yali Dou, Ulrich Steidl, Thomas Jenuwein, Matthew J. Gamble, and Arthur I. Skoultchi. H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction.
Proc Natl Acad Sci U S A, First published June 8, 2020.

2: Mishra LN, Hayes J. A nucleosome-free region locally abrogates histone H1-dependent restriction of linker DNA accessibility in chromatin. J Biol Chem. 2018 Oct 29. pii: jbc.RA118.005721. doi: 10.1074/jbc.RA118.005721.

3: Mishra LN, Shalini V, Gupta N, Ghosh K, Suthar N, Bhaduri U, Rao MRS. Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements. Epigenetics Chromatin. 2018 Aug 1;11(1):43. doi: 10.1186/s13072-018-0214-0.

4: Gupta N, Pentakota S, Mishra LN, Jones R, Rao MR. Identification of Posttranslational Modifications of Endogenous Chromatin Proteins From Testicular Cells by Mass Spectrometry. Methods Enzymol. 2017;586:115-142. doi: 10.1016/bs.mie.2016.09.031. PubMed PMID: 28137559.

5: Mishra LN, Pepenella S, Rogge R, Hansen JC, Hayes JJ. Acetylation Mimics Within a Single Nucleosome Alter Local DNA Accessibility In Compacted Nucleosome Arrays. Sci Rep. 2016 Oct 6;6:34808. doi: 10.1038/srep34808. PubMed PMID: 27708426; PubMed Central PMCID: PMC5052607.

6: Mishra LN, Gupta N, Rao SM. Mapping of post-translational modifications of spermatid-specific linker histone H1-like protein, HILS1. J Proteomics. 2015 Oct 14;128:218-30. doi: 10.1016/j.jprot.2015.08.001. Epub 2015 Aug 6. PubMed PMID: 26257145.

7: Naz S, Ranganathan P, Bodapati P, Shastry AH, Mishra LN, Kondaiah P. Regulation of S100A2 expression by TGF-β-induced MEK/ERK signalling and its role in cell migration/invasion. Biochem J. 2012 Oct 1;447(1):81-91. doi: 10.1042/BJ20120014. PubMed PMID: 22747445.
8. 2. Michael A. Willcockson*, Sean E. Healton*, Cary N. Weiss*, Boris A. Bartholdy*,Yair M. Botbol, Laxmi N. Mishra, Tommy Wilson , Hugo Pinto , Maxim Maron , Karin Skalina , Laura Norwood Toro , Jie Zhao , Chul-Hwan Lee , Harry Hou , Nevin Yusufova , Cem Meydan , Adewola Osunsade , Yael David , Ethel Cesarman , Ari Melnick , Simone Sidoli , Benjamin Garcia , Winfried Edelmann , Fernando Macian, and Arthur I. Skoultchi.. H1 linker histones regulate the balance of repressive and active chromatin domains via localized genomic compaction (2020). Nature
1 Protocol reviewed
Endocytosis Detection in Magnaporthe oryzae
Authors:  Muxing Liu and Zhengguang Zhang, date: 08/05/2019, view: 2287, Q&A: 0
Endocytosis is an intracellular trafficking pathway that occurs in nutrient uptake, signal transduction and reconstruction of cell polarity and is conserved in eukaryotic cells. In fungi, endocytosis plays crucial roles in the physiology of hyphal ...
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1 Protocol edited
A Simple and Efficient Method for Concomitant Isolation and Culture of Enriched Astroglial and Microglial Cells from the Rat Spinal Cord
Authors:  Pooja Shree Mishra and Trichur R Raju, date: 01/20/2020, view: 2423, Q&A: 0
Investigations into glial biology have contributed substantially in understanding the physiology and pathology of the nervous system. However, intricacies of the neuron-glial and glial-glial interactions in vivo present significant ...
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