Jian Ding
  • Faculty, Jian Ding
Research focus
  • Molecular biology
  • gene regulation, cardiology, mitochondrial biology


PhD, Iowa State University, 2010

Lab information

Ding Lab


1. Yang Y-H*, Huang J and Ding J (2003) Interaction between exogenous brassinolide, IAA and BAP in secondary metabolism of cultured Onosma paniculatum cells. Plant Growth Regulation. 39(3): 253–261

2. Ding J, Shi S, Jiang B-H, Yang Y-H*, Huang J, Shen H-G, Xia K, Zhang J, and Jiang X (2004) Effects of methyl jasmonate with IAA and 6-BAP on the secondary metabolism of cultured Onosma paniculatum cells. In Vitro Cellular & Developmental Biology-Plant. 40(6):581–585

3. Ding J, Tchaicheeyan O, Ambrosio L* (2010) Drosophila Raf’s N-terminus contains a novel conserved region and can contribute to Torso RTK signaling. Genetics. 184(3):717-729

4. Mckay J, Wang X, Ding J, Buss JE, Ambrosio L* (2011) H-RAS resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1813(2):298-307

5. Ding J, and Wang D-Z* (2011) “RISCing” the heart: In vivo identification of cardiac miRNA targets by RISCom. Circulation Research. 108(1):3-5

6. Chen J, Huang Z-P, Seok H, Ding J, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang D-Z* (2013) miR-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circulation Research. 112(12):1557-1568

7. Seok H, Chen J, Kataoka M, Huang Z-P, Ding J, Yan J, Hu X, Wang D-Z* (2014) Loss of microRNA-155 protects the heart from pathological cardiac hypertrophy. Circulation Research. 114(10):717-729

8. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang D-Z, Li K, Wang J, Wangders RA, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK*, Pu WT* (2014) Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 20(6):616-623

9. Ambrosio L*, Morriss S, Riaz A, Bailey R, Ding J, MacIntosh GC* (2014) Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. PLoS ONE. 9:e105444. doi:10.1371/journal.pone.0105444

10. Huang Z-P, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng Z-L, Seidman CE, Seidman JG, Pu WT, Wang D-Z* (2015) Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. The Journal of Clinical Investigation 125(11): 4122-4134

11. Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng Z-L, Pu WT, Wang D-Z* (2015) Trbp regulates heart function through miRNA-mediated Sox6 repression. Nature Genetics. 47(7): 776-783

12. Ding J, Wang D-Z* (2015) Mystery of Trbp, tale of a RBP in the miRNA pathway. Cell Cycle. 14(19):3007-3008

13. Ding J, Nie M, Liu J, Hu X, Ma L, Deng Z-L, Wang D-Z* (2016) Trbp is required for differentiation and normal regeneration of skeletal muscle. PLoS ONE. 11:e0155349. doi: 10.1371/journal.pone.0155349

14. Ding J*, Lin Z-Q, Jiang J-M, Seidman CE, Seidman JG, Pu WT, Wang D-Z* (2016) Preparation of rAAV9 to overexpress or knockdown genes in mouse heart. Journal of Visualized Experiments. 118:e54787, doi:10.3791/54787

15. Diniz G, Huang Z-P, Liu J, Chen J, Ding J, Fonseca R, Barreto-Chaves ML, Donato J, Hu X, Wang D-Z* (2017) Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increase energy expenditure without affecting cardiac hypertrophy. Clinical Science. 131(24):2885-2099

16. Wang K, Xu Y, Sun Q, Long J, Liu J, Ding J* (2018) Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms. Free Radical Research. In press doi: 10.1080/10715762.2018.1453137.

Book Chapters:

1. Ding J, and Wang D-Z, (2013) “Role of microRNAs in cardiac hypertrophy and post-infarction remodeling”. Molecular Mechanisms of Cardiac Remodeling. “Advances in Biochemistry in Health and Disease” 5: 293-311. Springer, New York.
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