Giacomo Garibotto Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
1 protocol

Francesca Costigliolo Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
1 protocol

Samantha Milanesi Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
1 protocol

Daniela Verzola
  • Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
  • 1 Author merit

Education

PhD in Biology and Pathophysiology of cardiovascular disease, kidney disease, hypertension, metabolism, Department of Internal Medicine, University of Genoa, Italy, 2005

Current position

Researcher in Nephrology, Department of Internal Medicine, Univerity of Genoa, Italy

Publications (since 2014)

  1. Verzola D, Cappuccino L, D’Amato E, Villaggio B, Gianiorio F, Mij M, Simonato A, Viazzi F, Salvidio G, Garibotto G ENHANCED GLOMERULAR TOLL-LIKE RECEPTOR 4 EXPRESSION AND SIGNALING IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY AND MICROALBUMINURIA. Kidney Int 2014 86:1229-1243 
  2. Verzola D, Ratto E, Villaggio B, Parodi EL, Pontremoli R, Garibotto G, Viazzi F. URIC ACID PROMOTES APOPTOSIS IN HUMAN PROXIMAL TUBULE CELLS BY OXIDATIVE STRESS AND THE ACTIVATION OF NADPH OXIDASE NOX 4. PLoS One. 2014 Dec 16;9(12):e115210. doi: 10.1371/journal.pone.0115210. eCollection 2014.
  3. Ratto E, Viazzi F, Verzola D, Bonino B, Gonnella A, Parodi EL, Bezante GP, Leoncini G, Pontremoli R. Metabolic syndrome is associated with left ventricular dilatation in primary hypertension J Hum Hypertens. 2015 Jun 25. Doi: 10.1038/jhh.2015.67 
  4. G Garibotto, A Sofia, R Russo, E Paoletti, A Bonanni, E L. Parodi, F Viazzi, D Verzola INSULIN SENSITIVITY OF MUSCLE PROTEIN METABOLISM IN PATIENTS WITH CHRONIC KIDNEY DISEASE. Kidney Int. 2015 Dec;88(6):1419-1426. doi: 10.1038/ki.2015.247. 
  5. Barisione C, Garibaldi S, Brunelli C, Balbi M, Spallarossa P, Canepa M, Ameri P, Viazzi F, Verzola D, Lorenzoni A, Baldassini R, Palombo D, Pane B, Spinella G, Ghigliotti G PREVALENT CARDIAC, RENAL AND CARDIORENAL DAMAGE IN PATIENTS WITH ADVANCED ABDOMINAL AORTIC ANEURYSMS. Intern Emerg Med. 2016 Mar;11(2):205-12. doi: 10.1007/s11739-015-1328-z. 
  6. Barisione C, Garibaldi S, Furfaro AL, Nitti M, Palmieri D, Passalacqua M, Garuti A, Verzola D, Parodi A, Ameri P, Altieri P, Fabbi P, Ferrar PF, Brunelli C, Arsenescu V, Balbi M, Palombo D, Ghigliotti G. MODERATE INCREASE OF INDOXYL SULFATE PROMOTES MONOCYTE TRANSITION INTO PROFIBROTIC MACROPHAGES. PLoS One. 2016 Feb 29;11(2):e0149276. doi: 10.1371/journal.pone.0149276 
  7. Viazzi F, Leoncini G, Ratto E, Storace G, Gonnella A, Garneri D, Bonino B, Cappadona F, Parodi EL, Verzola D, Garibotto G, Pontremoli R. PERIPHERAL ARTERY DISEASE AND BLOOD PRESSURE PROFILE ABNORMALITIES IN HEMODIALYSIS PATIENTS. Nephrol. 2016 Jun 1. 
  8. Garibotto G, Verzola D. STUDYING MUSCLE PROTEIN TURNOVER IN CKD. Clin J Am Soc Nephrol. 2016 Jul 7;11(7):1131-2. doi: 10.2215/CJN.04790516 
  9. Verzola D, Ansaldo F, Milanesi S, Parodi EL, Rosa GM, Sofia A, Bonanni A, Viazzi F, Balbi M, Garibotto G. INTERORGAN HANDLING OF FIBROBLAST GROWTH FACTOR-23 IN HUMANS. Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F254-F258. doi: 10.1152/ajprenal.00396.2016 
  10. Verzola D, Bonanni A, Sofia A, Montecucco F, D'Amato E, Cademartori V, Parodi EL, Viazzi F, Venturelli C, Brunori G, Garibotto G. TOLL-LIKE RECEPTOR 4 SIGNALLING MEDIATES INFLAMMATION IN SKELETAL MUSCLE OF PATIENTS WITH CHRONIC KIDNEY DISEASE. J Cachexia Sarcopenia Muscle. 2017 Feb;8(1):131-144. doi: 10.1002/jcsm.12129 
  11. Verzola D, Milanesi S, Bertolotto M, Garibaldi S, Villaggio B, Brunelli C, Balbi M, Ameri P, Montecucco F, Palombo D, Ghigliotti G, Garibotto G, Lindeman JH, Barisione C. MYOSTATIN MEDIATES ABDOMINAL AORTIC ATHEROSCLEROSIS PROGRESSION BY INDUCING VASCULAR SMOOTH MUSCLE CELL DYSFUNCTION AND MONOCYTE RECRUITMENT.Sci Rep. 2017 Apr 13;7:46362. doi: 10.1038/srep46362 
  12. Esposito P, La Porta E, Calatroni M, Grignano MA, Milanesi S, Verzola D, Battaglia Y, Gregorini M, Libetta C, Garibotto G, Rampino T. MODULATION OF MYOSTATIN/HEPATOCYTE GROWTH FACTOR BALANCE BY DIFFERENT HEMODIALYSIS MODALITIES.Biomed Res Int. 2017;2017:7635459. doi: 10.1155/2017/7635459. Epub 2017 Mar 28. 
  13. Garibotto G, Verzola D, Vettore M, Tessari P. THE CONTRIBUTION OF MUSCLE, KIDNEY, AND SPLANCHNIC TISSUES TO LEUCINE TRANSAMINATION IN HUMANS.Can J Physiol Pharmacol. 2018 Apr;96(4):382-387. doi: 10.1139/cjpp-2017-0439. 
  14. Garibotto G, Carta A, Picciotto D, Viazzi F, Verzola D. TOLL-LIKE RECEPTOR-4 SIGNALING MEDIATES INFLAMMATION AND TISSUE INJURY IN DIABETIC NEPHROPATHY. J Nephrol. 2017 Dec;30(6):719-727. doi: 10.1007/s40620-017-0432-8. 
  15. Esposito P, La Porta E, Grignano MA, Verzola D, Milanesi S, Ansaldo F, Gregorini M, Libetta C, Garibotto G, Rampino T. SOLUBLE TOLL-LIKE RECEPTOR 4: A NEW PLAYER IN SUBCLINICAL INFLAMMATION AND MALNUTRITION IN HEMODIALYSIS PATIENTS. JRen Nutr. 2018 Jul;28(4):259-264. doi: 10.1053/j.jrn.2017.11.006 
  16. Garibotto G, Sofia A, Parodi EL, Ansaldo F, Bonanni A, Picciotto D, Signori A, Vettore M, Tessari P, Verzola D. EFFECTS OF LOW-PROTEIN, AND SUPPLEMENTED VERY LOW-PROTEIN DIETS, ON MUSCLE PROTEIN TURNOVER IN PATIENTS WITH CKD.Kidney Int Rep. 2018 Jan 11;3(3):701-710. doi: 10.1016/j.ekir.2018.01.003. eCollection 2018 May.  
  17. S. Milanesi, D. Verzola, F. Cappadona, B. Bonino, A. Murugavel, R. Pontremoli, G. Garibotto, F. Viazzi URIC ACID AND ANGIOTENSIN II ADDITIVELY PROMOTE INFLAMMATION AND OXIDATIVE STRESS IN HUMAN PROXIMAL TUBULE CELLS BY ACTIVATION OF TOLL LIKE RECEPTOR 4 J Cell Phisiol. 2018 Dec 10. doi: 10.1002/jcp.27929.
1 Protocol published
Immunohistochemical Staining of TLR4 in Human Skeletal Muscle Samples
Authors:  Daniela Verzola, Samantha Milanesi, Francesca Costigliolo and Giacomo Garibotto, date: 01/20/2019, view: 370, Q&A: 0
Growing evidence suggests the involvement of TLR4, a receptor in the innate immune system, in muscle loss in uremia. Recently, we have evaluated TLR4 in human skeletal muscle from chronic kidney disease patients, by immunohistochemistry and image ...
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