Yu-Qing Zhang
  • Professor, Soochow University, China
Research focus
  • Applied Biology
  • The research interesting focuses on characterizing mechanical and biological properties and developing new use of silk biomaterial, in particular, applications of silk protein in biomedical materials, biomedicines, daily fine chemicals or cosmetics.
  • 1 Author merit


PhD, Shinshu University, 2005

Lab information

Silk Biotech Lab


  1. Zhu, L., Zou, D. Q., Fan, Z. Q., Wang, N., Bo, Y. Y., Zhang, Y. Q. and Guo, G. (2018). Properties of a novel carboxymethyl chitosan derived from silkworm pupa. Arch Insect Biochem Physiol 99(2): e21499. 
  2. Yin, X. L., Lv, Y., Wang, S. and Zhang, Y. Q. (2018). Morusin suppresses A549 cell migration and induces cell apoptosis by downregulating the expression of COX2 and VEGF genes. Oncol Rep 40(1): 504-510. 
  3. Zhao, J. G. and Zhang, Y. Q. (2018). A novel estimation method of total flavonoids in an edible medicinal mulberry leaves by ultrasound-assisted hydroalcohol-acid extraction and HPLC-DAD. J Appl Bot Food Qual 91: 114-119.
  4. Zhao, Z.-L., Li, W.-W., Wang, F. and Zhang, Y.-Q. (2018). Using of hydrated lime water as a novel degumming agent of silk and sericin recycling from wastewater. J Clean Prod 172: 2090-2096. 
  5. Yin, X. L., Liu, H. Y. and Zhang, Y. Q. (2017). Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice. Food Nutr Res 61(1): 1368847. 
  6. Ding, B., Wan, L.-Z. and Zhang, Y.-Q. (2017). Biosafety Evaluation of Three Sodium Lauryl N-Amino Acids Synthesized from Silk Industrial Waste in Mice. J Surfactants Deterg 20(5): 1173-1187. 
  7. Cao, T. T. and Zhang, Y. Q. (2017). The potential of silk sericin protein as a serum substitute or an additive in cell culture and cryopreservation. Amino Acids 49(6): 1029-1039. 
  8. Li, W. W., Wang, H. Y. and Zhang, Y. Q. (2017). A novel chitosan hydrogel membrane by an improved electrophoretic deposition and its characteristics in vitro and in vivo. Mater Sci Eng C Mater Biol Appl 74: 287-297. 
  9. Wang, F. and Zhang, Y. Q. (2017). Effects of alkyl polyglycoside (APG) on Bombyx mori silk degumming and the mechanical properties of silk fibroin fibre. Mater Sci Eng C Mater Biol Appl 74: 152-158. 
  10. Liu, D., Zhou, J. L., Hong, F. and Zhang, Y. Q. (2017). Lung inflammation caused by long-term exposure to titanium dioxide in mice involving in NF-kappaB signaling pathway. J Biomed Mater Res A 105(3): 720-727. 
  11. Wang, J., Zhao, L.-J. and Zhang, Y.-Q. (2017). UV Irradiation and Salicylic Acid Immersion Enhance the Level of Mulberroside A in Isolated Mulberry Branches—A Huge Amount of Agro-Waste. Waste Biomass Valorization 8(8): 2643-2651.
  12. Xu, B. Q. and Zhang, Y. Q. (2017). Bioactive Components Of Gynura Divaricata And Its Potential Use In Health, Food And Medicine: A Mini-Review. Afr J Tradit Complement Altern Med 14(3): 113-127. 
  13. Hong, F., Yu, X., Wu, N. and Zhang, Y. Q. (2017). Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Toxicol Res (Camb) 6(2): 115-133. 
  14. Yu, X., Hong, F. and Zhang, Y. Q. (2016). Cardiac inflammation involving in PKCepsilon or ERK1/2-activated NF-kappaB signalling pathway in mice following exposure to titanium dioxide nanoparticles. J Hazard Mater 313: 68-77. 
  15. Zhao, J. G. and Zhang, Y. Q. (2016). A new estimation of the total flavonoids in silkworm cocoon sericin layer through aglycone determination by hydrolysis-assisted extraction and HPLC-DAD analysis. Food Nutr Res 60: 30932. 
  16. Liu, H. Y., Wang, J., Ma, J. and Zhang, Y. Q. (2016). Interference effect of oral administration of mulberry branch bark powder on the incidence of type II diabetes in mice induced by streptozotocin. Food Nutr Res 60: 31606. 
  17. Hong, J., Hong, F., Ze, Y. and Zhang, Y.-Q. (2016). The nano-TiO2 exposure can induce hepatic inflammation involving in a JAK–STAT signalling pathway. J Nanopart Res 18(6): 162.
  18. Yu, X., Hong, F. and Zhang, Y. Q. (2016). Bio-effect of nanoparticles in the cardiovascular system. J Biomed Mater Res A 104(11): 2881-2897. 
  19. Qiu, F., He, T. Z. and Zhang, Y. Q. (2016). The isolation and the characterization of two polysaccharides from the branch bark of mulberry (Morus alba L.). Arch Pharm Res 39(7): 887-896. 
  20. Liu, D., Yang, P. and Zhang, Y. Q. (2016). Water-soluble extract of Saxifraga stolonifera has anti-tumor effects on Lewis lung carcinoma-bearing mice. Bioorg Med Chem Lett 26(19): 4671-4678. 
  21. Cao, T. T. and Zhang, Y. Q. (2016). Processing and characterization of silk sericin from Bombyx mori and its application in biomaterials and biomedicines. Mater Sci Eng C Mater Biol Appl 61: 940-952. 
  22. Ding, B., Lv, Y. and Zhang, Y.-Q. (2016). Anti-tumor effect of morusin from the branch bark of cultivated mulberry in Bel-7402 cells via the MAPK pathway. RSC Adv 6(21): 17396-17404.
  23. Zhu, L. and Zhang, Y. Q. (2016). Postoperative anti-adhesion ability of a novel carboxymethyl chitosan from silkworm pupa in a rat cecal abrasion model. Mater Sci Eng C Mater Biol Appl 61: 387-395. 
  24. Hong, J. and Zhang, Y. Q. (2016). Murine liver damage caused by exposure to nano-titanium dioxide. Nanotechnology 27(11): 112001. 
  25. Zheng, L. P., Zou, T., Ma, Y. J., Wang, J. W. and Zhang, Y. Q. (2016). Antioxidant and DNA Damage Protecting Activity of Exopolysaccharides from the Endophytic Bacterium Bacillus cereus SZ1. Molecules 21(2). 
  26. Wang, F., Cao, T. T. and Zhang, Y. Q. (2015). Effect of silk protein surfactant on silk degumming and its properties. Mater Sci Eng C Mater Biol Appl 55: 131-136. 
  27. Wang, F. and Zhang, Y. Q. (2015). Bioconjugation of silk fibroin nanoparticles with enzyme and Peptide and their characterization. Adv Protein Chem Struct Biol 98: 263-291. 
  28. Wang, H.-Y., Chen, Y.-Y. and Zhang, Y.-Q. (2015). Processing and characterization of powdered silk micro- and nanofibers by ultrasonication. Mater Sci Eng C 48: 444-452. 
  29. Wang, H. Y. and Zhang, Y. Q. (2015). Processing silk hydrogel and its applications in biomedical materials. Biotechnol Prog 31(3): 630-640. 
  30. Xu, B. Q., Yang, P. and Zhang, Y. Q. (2015). Hypoglycemic activities of lyophilized powder of Gynura divaricata by improving antioxidant potential and insulin signaling in type 2 diabetic mice. Food Nutr Res 59: 29652. 
  31. Zhao, J.-G. and Zhang, Y.-Q. (2015). Inhibition of the flavonoid extract from silkworm cocoons on DMBA/UVB-induced skin damage and tumor promotion in BALB/c mice. Toxicol Res 4(4): 1016-1024.
  32. Cao, T. T. and Zhang, Y. Q. (2015). Viability and proliferation of L929, tumour and hybridoma cells in the culture media containing sericin protein as a supplement or serum substitute. Appl Microbiol Biotechnol 99(17): 7219-7228. 
  33. Zhu, L., Peng, L. and Zhang, Y. Q. (2015). The processing of chitosan and its derivatives and their application for postoperative anti-adhesion. Mini Rev Med Chem 15(4): 330-337. 
1 Protocol published
SDS-PAGE for Silk Fibroin Protein
Author:  Yu-Qing Zhang, date: 10/20/2018, view: 106, Q&A: 0
The method and detailed procedure of SDS-PAGE for silk proteins are exactly the same as for other proteins, but the electrophoresis profile of silk protein is often unsatisfactory. The main reason is that their molecular masses are too large, and ...