Yu-Qing Zhang
  • Faculty, Soochow University
Research focus
  • Biomaterials
  • The research interesting focuses on characterizing mechanical and biological properties and developing new use of silk biomaterial, in particular, applications of silk protein in biomedical materials, biomedicines, daily fine chemicals or cosmetics.


PhD, Shinshu University, 2005

Lab information

Silk Biotech Lab


1. Lin Zhu, De-Qing Zou, Zuo-Qing Fan, Na Wang, Ying-Ying Bo, Yu-Qing Zhang*, Guang Guo*(2018). Properties of a novel carboxymethyl chitosan derived from silkworm pupa. Arch. Insect Biochem. Physiol. 2018;e21499. DOI:10.1002/arch.21499
2. Xiao-Lu Yin, Yi Lv, Yu-Qing Zhang*(2018). Morusin suppresses A549 cell migration and induces cell apoptosis by down-regulating expression of COX-2 and VEGF. Oncology Reports 40: 504-510. DOI:10.3892/or.2018.6431
3. Jin-Ge Zhao and Yu-Qing Zhang*(2018). A novel estimation method of total flavonoids in an edible medicinal mulberry leaves by ultrasound-assisted hydroalcohol-acid extraction and HPLC-DAD. Journal of Applied Botany and Food Quality 91: 114-119. DOI:10.5073/JABFQ.2018.091.016
4. Zhi-Lin Zhao; Li, Wen-Wen; Wang, Fei; & Zhang, Y-Q.*(2018) Using of hydrated lime water as a novel degumming agent of silk and sericin recycling from wastewater. Journal of Cleaner Production 172: 2090-2096. DOI:
5. Xiao-Lu Yin, Hua-Yu Liu, Yu-Qing Zhang*(2017). Oral administration of mulberry branch bark powder improves significantly hyperglycemia and hyperinsulinemia in type II diabetic mice. Food & Nutrition Research, 61(1), 1368847. DOI:10.1080/16546628.2017.1368847
6. Biao Ding, Liang-Ze Wan, Yu-Qing Zhang*(2017). Biosafety evaluation of three sodium lauryl N-amino acids synthesized from silk industrial waste in mice. Journal of Surfactants and Detergents 2017, 20(5), 1173-1187. DOI: 10.1007/s11743-017-1995-z
7. Cao, T.T., & Zhang, Y.Q*(2017). The potential of silk sericin protein as a serum substitute in cell culture and cryopreservation. Amino Acids 49(6), 1029-1039. DOI: 10.1007/s00726-017-2396-3
8. Li, Wen-wen, Wang, H-Y., Li, W-W. Zhang, Y-Q*(2017). A novel chitosan hydrogel membrane by an improved electrophoretic deposition and its characteristics in vivo and in vitro. Materials Science and Engineering C 74: 287–297. DOI: 10.1016/j.msec.2016.12.005
9. Fei Wang, Yu-Qing Zhang*(2017). Effects of alkyl polyglycoside (APG) on Bombyx mori silk degumming and the mechanical properties of silk fibroin fibre. Materials Science and Engineering C 274: 152–158.
10. Dong Liu, Yu-Qing Zhang*(2017). TiO2 nanoparticles exposure induces lung inflammation in mice via the NF-κB and IFN signalling pathways. Journal of Biomedical Material Research A 105(3): 720–727. doi: 10.1002/jbm.a.35945
11. Jiang Wang, Li-Jun Zhao, Yu-Qing Zhang*(2017). UV irradiation and salicylic acid immersion enhance the level of mulberroside A in isolated mulberry branches, a huge amount of agro-waste. Waste and Biomass Valorization 8(8): 2643-2651. DOI: 10.1007/s12649-016-9702-2
12. Bing-Qing Xu and Yu-Qing Zhang*(2017). The bioactive components of Gynura divaricata and its potential use in health food and medicine: A review. African Journal of Traditional Complementary and Alternative Medicines 14(3): 113-127. doi:10.21010/ajtcam. v14i3.12
13. Hong, F*., Yu, X., & Zhang, Y.-Q*. (2017). Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Toxicol Res, 6, 115–133.
14. Yu, Xiaohong; Hong, Fashui*; Zhang, Yu-Qing*(2016). Cardiac inflammation involving in PKCε or ERK1/2 -activated NF-κB signalling pathway in mice following exposure to titanium dioxide nanoparticles. Journal of Hazardous Materials 2016, 313, 68-77. DOI:10.1016/j.jhazmat.2016.03.088
15. Jin-Ge Zhao and Yu-Qing Zhang*(2016). A new estimation of the total flavonoids in silkworm cocoon sericin layer through aglycone determination by hydrolysis-assisted extraction and HPLC-DAD analysis. Food & Nutrition Research 60, 30932. DOI:10.3402/fnr.v60.30932
16. Hua-Yu Liu, Jiang Wang,Jing Ma, Yu-Qing Zhang*(2016). Interference effect of oral administration of mulberry branch bark powder on the incidence of type 2 diabetic mice induced by streptozotocin. Food & Nutrition Research 60, 31606(11). DOI:10.3402/fnr.v60.31606
17. Jie Hong, Fashui Hong*, Yuguan Ze, Yu-Qing Zhang*(2016). The nano-TiO2 exposure can induce hepatic inflammation involving in a JAK–STAT signalling pathway. Journal of Nanoparticles Research 18, 162(9). doi:10.1088/0957-4484/27/11/112001
18. Yu, Xiaohong; Hong, Fashui*; Zhang, Yu-Qing*(2016). Bio-effect of nanoparticles in the cardiovascular system. Journal of Biomedical Material Research A 104A(11), 2881–2897. DOI: 10.1002/jbm.a.35804
19. Fan Qiu, Tian-Zhen He, Yu-Qing Zhang*(2016). Two polysaccharides isolated from mulberry branch bark and their antioxidant activity. Archives of Pharmacal Research. 39(5), 887-896. DOI: 10.1007/s12272-016-0742-8
20. Dong Liu, Master; Ping Yang, Yu-Qing Zhang*(2016). Water-soluble extract of Saxifraga stolonifera has anti-tumor effects on Lewis lung carcinoma-bearing mice. Bioorganic & Medicinal Chemistry Letters 26(19), 4671-4678. DOI: 10.1016/j.bmcl.2016.08.051
21. Cao, T., & Zhang, Y-Q*. (2016). Processing and characterization of silk sericin from Bombyx mori and its application in biomaterials and biomedicines. Mater Sci Eng C 61: 940–952. doi:10.1016/j.msec.2015.12.082.
22. Ding, B., Lv, Y., & Zhang, Y.-Q*. (2016). Anti-tumor effect of morusin from the branch bark of cultivated mulberry in Bel-7402 cells via the MAPK pathway. RSC Adv 6: 17396–17404. DOI: 10.1039/C5RA21321E
23. Zhu, L., & Zhang, Y-Q*. (2016). Postoperative anti-adhesion ability of a novel carboxymethyl chitosan from silkworm pupa in a rat cecal abrasion model. Mater Sci Eng C 61: 387–395. doi:10.1016/j.msec.2015.12.080
24. Hong, J., & Zhang, Y-Q*. (2016). Murine liver damage caused by exposure to nano-titanium dioxide. Nanotechnology 27: 112001. doi:10.1088/0957-4484/27/11/112001
25. Zheng, L. P., Zou, T., Ma, Y. J., Wang, J. W., & Zhang, Y. Q*. (2016). Antioxidant and DNA Damage Protecting Activity of Exopolysaccharides from the Endophytic Bacterium. Molecules 21(174): 1–15. doi:10.3390/molecules21020174
26. Wang, F., Cao, T.-T., & Zhang, Y.-Q*. (2015). Effect of silk protein surfactant on silk degumming and its properties. Mater Sci Eng C 55: 131–136. doi:10.1016/j.msec.2015.05.041
27. Wang, F., & Zhang, Y.-Q*. (2015). Charpter 8 Bioconjugation of Silk Fibroin Nanoparticles with Enzyme and Peptide and Their Characterization. Adv Prot Chem Str Biol 98: 263–291.
28. Wang, H.-Y., Chen, Y.-Y., & Zhang, Y.-Q*. (2015). Processing and characterization of powdered silk micro- and nanofibers by ultrasonication. Mater Sci Eng C 48: 444–452. doi:10.1016/j.msec.2014.12.028
29. Wang, H.-Y., & Zhang, Y.-Q*. (2015). Processing silk hydrogel and its applications in biomedical materials. Biotechnol Prog 31(3), 630–640. DOI: 10.1002/btpr.2058
30. Xu, B., Yang, P., & Zhang, Y.-Q*. (2015). Hypoglycaemic activities of lyophilized powder of Gynura divaricata by improving antioxidant potential and insulin signalling in type 2 diabetic mice. Food Nutr Res 59: 29652. DOI:10.3402/fnr.v59.29652
31. Jin-Ge Zhao and Yu-Qing Zhang* (2015). Inhibition of the flavonoid extract from silkworm cocoons on DMBA/UVB-induced skin damage and tumor promotion in BALB/C mouse. Toxicology Research 4: 1016-1024. DOI: 10.1039/C5TX00087D
32. Ting-Ting Cao & Yu-Qing Zhang* (2015). Viability and proliferation of L929, tumour and hybridoma cells in the culture media containing sericin protein as a supplement or serum substitute. Applied Microbiology Biotechnology 99(17): 7219-7228. DOI:10.1007/s00253-015-6576-3.
33. Lin Zhu, Lin Peng and Yu-Qing Zhang* (2015). The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion. Mini-Reviews in Medicinal Chemistry 15(4): 330-337.