Srinath Govindarajan
  • Post-Doc, Srinath Govindarajan
Research focus
  • Immunology
  • Innate immunity, T cell biology, Innate like T cells, cancer biology and Rheumatoid arthritis


PhD, VIB-UGent Center for Inflammation and Research, 2017

Lab information

Dirk Elewaut Lab


1. ER stress in antigen presenting cells promotes NKT cell activation through endogenous neutral lipids. Srinath Govindarajan, Eveline Verheugen, Koen Venken, Djoere Gaublomme, Eva Cloots, Fien Gysens, Bruno G De Geest, Tan-Yun Cheng, Branch D Moody, Sophie Janssens, Michael Drennan, Dirk Elewaut. (EMBO Reports accepted Feb 2020). Q1– IF: 8.383

2. Quorum sensing molecules as a novel microbial factor impacting muscle cells. De Spiegeleer A, Elewaut D, Van Den Noortgate N, Janssens Y, Debunne N, Van Langenhove S, Govindarajan S, De Spiegeleer B, Wynendaele E. Biochim Biophys Acta Mol Basis Dis. 2020, Mar 1;1866(3):165646. Q1– IF: 4.328

3. Stabilization of cytokine mRNAs within invariant NKT cells requires the serine-threonine kinase IRE1 alpha. Govindarajan S, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys I, Devisscher L, Iwawaki T, Elewaut D, Drennan MB. Nature Communications. 2018 Dec 17;9(1):5340. Q1– IF: 12.96

4. It takes “guts” to cause joint inflammation: role of innate-like T cells. Céline Mortier*, Srinath Govindarajan*, Koen Venken, Dirk Elewaut. Frontiers in Immunology. 2018 Jun 29; 9: 1489. (*shared 1st author). Q1- IF: 6.429

5. Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1. Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN. Immunity. 2018, Jan 16;48(1):45-58. Q1- IF: 24.082

6. Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma. Mérédis Favreau, Eline Menu, Djoere Gaublomme, Karin Vanderkerken, Sylvia Faict, Ken Maes, Elke De Bruyne, Srinath Govindarajan, Michael Drennan, Serge Van Calenbergh, Xavier Leleu, Lennart Zabeau, Jan Tavernier, Koen Venken, and Dirk Elewaut. Leukemia. 2017 Dec; 31(12). Q1– IF:12.384

7. A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis. Katelijne De Wilde, Arne.M, Stijn Lambrecht, Peggy Jacques, Michael Drennan, Karlijn Debusschere, Srinath Govindarajan, Julie Coudenys, Eveline Verheugen, Fien Windels, Rik Loris, D.G. Mcgonagle, Rudi Beyaert, Geert Vanloo, Dirk Elewaut. Annals of the Rheumatic Diseases. Q1– IF:12.384

8. NKT sublineage specification and survival requires the ubiquitin modifying enzyme TNFAIP3/A20. Michael Drennan*, Srinath Govindarajan*, Eveline Verheugen, Jonathan Coquet, Jens Staal, Conor McGuire, Tom Taghon, Georges Leclercq, Rudi Beyaert, Geert van Loo, Bart Lambrecht, and Dirk Elewaut. J Exp Med. Aug 22 2016. (*shared 1st author). Q1– IF:12.515

9. Design of cholesterol arabinogalactan anchored liposomes for asialoglycoprotein receptor mediated targeting to hepatocellular carcinoma: In silico modeling, in vitro and in vivo evaluation. Pathak P, Dhawan V, Magarkar A, Danne R, Govindarajan S, Ghosh S, Steiniger F, Chaudhari P, Gopal V, Bunker A, Róg T, Fahr A,Nagarsenker M. Int J Pharm. 2016 Jul 25;509(1-2):149-58. Q1– IF:3.994

10. An Optimized Method for Isolating and Expanding Invariant Natural Killer T cells from Mouse Spleen. Govindarajan S, Elewaut D and Drennan MB. Journal of Visualized Experiments. J Vis Exp. 2015 Oct 29;(105):e53256. Q2– IF:1.1

11. The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages. Drennan MB, Govindarajan S, De Wilde K, Schlenner SM, Ware C, Nedospasov S, Rodewald HR, Elewaut D. J Immunol. 2014 Dec 15.193(12):5960-72. Q1– IF:4.985

12. Chemically tunable cationic polymer-bonded magnetic nanoparticles for gene magnetofection. Makoto Takafuji, Kumiko Kitaura, Takuro Nishiyama, Srinath Govindarajan, Vijaya Gopal, Takashi Imamura and Hirotaka Ihara. J. Mater. Chem. B, 2014, 2, 644. Q1– IF:4.872

13. Liposomes for targeting hepatocellular carcinoma: Use of conjugated arabinogalactan as targeting ligand. Shah SM, Goel PN, Jain AS, Pathak PO, Padhye SG, Govindarajan S, Ghosh SS, Chaudhari PR, Gude RP, Gopal V, Nagarsenker MS. Int J Pharm. 2014 Dec 30;477(1-2):128-39.. Q1– IF:3.994

14. Gene delivery into human cancer cells by cationic lipid-mediated magnetofection. Govindarajan S, Kitaura K, Takafuji M, Ihara H, Varadarajan KS, Patel AB, Gopal V. Int J Pharm. 2013 Mar 25;446(1-2):87-99. Q1– IF:3.994

15. Targeting human epidermal growth factor receptor 2 by a cell-penetrating peptide-affibody bioconjugate. Govindarajan S, Sivakumar J, Garimidi P, Rangaraj N, Kumar JM, Rao NM, Gopal V. Biomaterials. 2012 Mar;33(8):2570-82. Q1– IF:8.387

16. Synthesis and transfection efficiency of cationic oligopeptide lipids: role of linker. Gopal V, Xavier J, Kamal MZ, Govindarajan S, Takafuji M, Soga S, Ueno T, Ihara H, Rao NM. Bioconjug Chem. 2011 Nov 16;22(11):2244-54. Q1– IF:4.500

17. In vitro propagation of the medicinal herb - Clerodendrum inerme. Govindarajan S, Sridhar. V and Dr. Renuka R (2009). Advanced Bio-Tech: Journal of Advanced Biotechnology. Samanthi publications, Vol 9, Issue ΙΙΙ, pp 21-22.
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