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Reviewer
Nagesh Pasupala
  • Post-Doc, Johns Hopkins University
Research focus
  • Cell biology
  • Ubiquitin, Protein degradation, SUMO, DNA damage repair

Education

PhD, University of Hyderabad, India, 2011

Lab information

Prof. Cynthia Wolberger lab
http://wolberger.med.jhmi.edu/

Publications

1. Jason W. Westerbeck*, Nagesh Pasupala*, Mark Guillotte, Eva Szymanski,
Brooke C Matson, Ceceilia Esteban and Oliver Kerscher (2014). A SUMO-targeted
ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3
ligase Siz1. Molecular Biology of the Cell, Vol 25, 1-16. (* joint first authors)


2. Pasupala N, Easwaran S, Hannan A, Shore D, Mishra K. (2012). The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae. Eukaryotic Cell, Vol 11, 452-462.

3. Kentaro Ohkuni, Yoshimitsu Takahashi, Alyona Fulp, Josh Lawrimore, Wei-chun Au, Nagesh Pasupala, Ruben Levy-Mayers, Jack Warren, Alexander Strunnikov, Richard E. Baker, Oliver Kerscher, Kerry Bloom and Munira A. Basrai (2016). SUMO Targeted Ubiquitin Ligase (STUbL) Slx5 Regulates proteolysis of centromeric Histone H3 variant Cse4 and prevents its mislocalization to euchromatin.
Molecular Biology of the Cell, Vol 27, 1500-1510.

4. M.Sritharan, S.Ramadevi, N Pasupala, S.Taine, S Asuthkar (2005). In silico
identification and modeling of a putative iron-regualted TonB-dependent outer membrane receptor protein from the genome of Leptospira interrogans serovar Lai. Online Journal of Bioinformatics 6, 74-90.

5. Nagesh Pasupala, Gloria Dressnack-Sclar, Reuben Levy-Myers, Andrew Halleran, Oliver Kerscher. The Saccharomyces cerevisiae SUMO-targeted ubiquitin ligase subunit Slx5 reduces the toxicity and transcriptional activity of a poly-Q expanded protein (submitted to Cell Cycle).

6. Nagesh Pasupala, Marie Morrow, Cynthia Wolberger. Otub1 regulates the stability of the E2-Ubiquitin conjugating enzyme UbcH6 (manuscript under preparation).