Nagesh Pasupala
  • Post-Doc, uniformed services university of health sciences
Research focus
  • Cell biology
  • Ubiquitin, Protein degradation, SUMO, DNA damage repair


PhD, University of Hyderabad, India, 2011

Lab information

Prof. Chou Zen Giam


1. Nagesh Pasupala*, Marie Morrow*, Lauren T. Que, Barbara Malynn, Averil Ma, Cynthia Wolberger. OTUB1 non-catalytically regulates the stability of the E2 ubiquitin conjugating enzyme UBCH6. Journal of Biological Chemistry (2018). 293, 18285-18295. (* joint first authors).

2. Nagesh Pasupala*, Kentaro Ohkuni*, Jennifer Peek, Grace Lauren Holloway, Gloria Driessnack-Sclar, Reuben Levy-Myers, Richard E. Baker, Munira A. Basrai and Oliver Kerscher. SUMO-targeted ubiquitin ligases (STUbLs) reduce the toxicity and abnormal transcriptional activity associated with a mutant, aggregation-prone fragment of huntingtin. Front Genet. 2018 Sep 18;9:379. doi: 10.3389/fgene.2018.00379. eCollection 2018 (* joint first authors)

3. Kentaro Ohkuni, Yoshimitsu Takahashi, Alyona Fulp, Josh Lawrimore, Wei-chun Au, Nagesh Pasupala, Ruben Levy-Mayers, Jack Warren, Alexander Strunnikov, Richard E. Baker, Oliver Kerscher, Kerry Bloom and Munira A. Basrai (2016). SUMO Targeted Ubiquitin Ligase (STUbL) Slx5 Regulates proteolysis of centromeric Histone H3 variant Cse4 and prevents its mislocalization to euchromatin.
Molecular Biology of the Cell, Vol 27, 1500-1510.

4. Jason W. Westerbeck*, Nagesh Pasupala*, Mark Guillotte, Eva Szymanski, Brooke C Matson, Ceceilia Esteban and Oliver Kerscher (2014). A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1. Molecular Biology of the Cell, Vol 25, 1-16. (* joint first authors)

5. Pasupala N, Easwaran S, Hannan A, Shore D, Mishra K. (2012). The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae. Eukaryotic Cell, Vol 11, 452-462.

6. M.Sritharan, S.Ramadevi, N Pasupala, S.Taine, S Asuthkar (2005). In silico identification and modeling of a putative iron-regualted TonB-dependent outer membrane receptor protein from the genome of Leptospira interrogans serovar Lai. Online Journal of Bioinformatics 6, 74-90.
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