Prasanth Manohar
  • Post-Doc, Texas A&M University
Research fields
  • Biochemistry, Microbiology, Molecular Biology
Personal information

Education

PhD, Vellore Institute of Technology, 2019

Lab information

Center for Phage Technology - Young Lab
https://cpt.tamu.edu/people/

Research focus

Bacteriophage biology, Phage therapy, Phage lysis system, Gram-negative bacteria, Antibiotic resistance

Publications

https://scholar.google.co.in/citations?user=Bd2Eo7YAAAAJ&hl=en
• Khan FM, Manohar P, Godil VS, Mehra N, Oyejobi GK, Odiwuor N, Ahmad A, Huang G. The applications of animal models in phage therapy: an update. Human Vaccine and Immunotherapeutics, 2023.
• Shanthini T, Manohar P, Hua X, Leptihn S, Nachimuthu R. Detection of hypervirulent Klebsiella pneumoniae from clinical samples in Tamil Nadu. MedRxiv, 2023.
• Manohar P, Nachimuthu R, Leptihn S. Phage-antibiotic combination to control Pseudomonas aeruginosa-Candida two-species biofilms. BioRxiv, 2022.
• Manohar P, Loganathan A, Elangovan N, Tamizhselvi R, Nachimuthu R, Leptihn S. In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. BioRxiv, 2022.
• Manohar P, Loganathan A, Nachimuthu R, Loh B, Ma L, Leptihn S. Complete genome sequence of Pseudomonas phage Motto. In Microbiology Resource Announcements. 2022.
• Manohar P, Loh B, Elangovan N, Loganathan A, Nachimuthu R, Leptihn S. A multiwall-plate Caenorhabditis elegans assay for assessing the therapeutic potential of bacteriophages against clinical pathogens. 2022. In Microbiology Spectrum 10(1): e01393-21.
• Manohar P*, Madhav MR*, Bozdogan B, Loh B, Leptihn S, Nachimuthu R. Synergistic effects of phage-antibiotic combinations against Citrobacter amalonaticus. 2022. In ACS Infectious Diseases 8(1): 59-65.
• Ramesh N, Manohar P, Eniyan K, Archana L, Athira S, Loh B, Ma L, Leptihn S. A Lysozyme Murein Hydrolase with Broad-spectrum Antibacterial Activity from Enterobacter Phage myPSH1140. 2022. Antimicrobial Agents and Chemotherapy.
• Arumugam SN, Manohar P, Sukumaran S, Sadagopan S, Loh B, Leptihn S, Nachimuthu R. Antibacterial Efficacy of Lytic Phages against Multidrug-Resistant Pseudomonas aeruginosa Infections in Bacteraemia Mice Models. 2022. In BMC Microbiology 22:187.
• Vanlalruati RSC, Loganathan A, Manohar P, Sailo CV, Sanga Z, Ralte L, Zothanzama J, Kumar NS, Leptihn S, Nachimuthu R. The Emergence of Carbapenem-resistant Gram-negative Bacteria in the Mizoram Region, Northeast India. 2022. In Microbiology Research 13: 342-349.
• Loh B, Wang X, Hua X, Luo J, Zhang L, Ma L, Manohar P, Nachimuthu R, Grainge I, Yu Y, Leptihn S. Complete genomes of Pseudomonas aeruginosa bacteriophages Kaya, Guyu, Kopi and TehO. 2021. In Microbiology Resource Announcements 10(48): e01043-21.
• Loh B, Zhang L, Hua X, Yu Y, Ma L, Wang X, Manohar P, Nachimuthu R, Martins W, Toleman M, Leptihn S. Complete genome of the virulent Klebsiella pneumoniae phage Geezett infecting MDR clinical strains. 2021. In Microbiology Resource Announcements 10(48): e00685-21.
• Loh B, Wang X, Hua X, Chook HW, Ma L, Zhang L, Manohar P, Jin Y, Leptihn S. Complete genome of the lytic bacteriophage Phab24 that infects clinical strains of the nosocomial pathogen Acinetobacter baumannii. 2021. In Microbiology Resource Announcements 10(40), e00669.
• Loganathan A, Manohar P, Kandasamy E, Vinodkumar CS, Leptihn S, Nachimuthu R. Phage Therapy as a Revolutionary Medicine against Gram-positive Bacterial Infections. 2021. In Beni-Suef University Journal of Basic and Applied Sciences 10(1): 49.
• Ramesh N, Madhav MR, Manohar P, Leptihn S. Application of bacteriophages and its endolysin as a biocontrol measure. 2021. In Biological Control 160: 104678.
• Loh B, Gondil VS, Manohar P, Khan FM, Yang H, Leptihn S. Encapsulation and Delivery of Therapeutic phages. 2021. In Applied and Environmental Microbiology 87(5): e01979-20.
• Manohar P, Leptihn S, Lopes BS, Nachimuthu R. Dissemination of carbapenem-resistance and plasmids-encoding carbapenemases in Gram-negative bacteria isolates from India. 2021. In JAC-Antimicrobial Resistance 3(1): dlab015.
• Manohar P, Ramesh N, Leptihn S, Ravi A, Rudi K. Reduced Metagenomic sequencing (RMS) approach to determine the gut-associated phageome in mother-child. 2021. In Human Microbiome Journal 19: 100078.
• Manohar P, Loh B, Leptihn S. Will the overuse of antibiotics during the coronavirus pandemic accelerate antimicrobial resistance of bacteria? 2020. In Infectious Microbes & Diseases 2: 87-88.
• Manohar P, Loh B, Nachimuthu R, Hua X, Welburn SC, Leptihn C. Secondary bacterial infections in patients with viral pneumoniae. 2020. In Frontiers in Medicine 7: 420.
• Manohar P, Loh B, Athira S, Nachimuthu R, Hua X, Welburn SC, Leptihn C. Secondary bacterial infections during pulmonary viral diseases: Phage therapeutics as alternatives to antibiotics? 2020. In Frontiers in Microbiology 11: 1434.
• Loh B, Chen J, Manohar P, Yu Y, Hua X, Leptihn S. A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. 2020. In Frontiers in Microbiology 11:579802.
• Sinha A, Eniyan K, Manohar P, Ramesh N, Bajpai U. Characterization and genome analysis of B1 sub-cluster mycobacteriophage PDRPxv. 2020. In Virus Research 279: 197884.
• Nachimuthu R, Kannan VR, Bozdogan B, Krishnakumar V, Pandiyan KS, Manohar P. CTX-M-type ESBL-mediated resistance to third-generation cephalosporins and conjugative transfer of resistance in Gram-negative bacteria isolated from hospitals in Tamil Nadu, India. 2020. In Access Microbiology 3(3): 000142.
• Manohar P and Ramesh N. Improved lyophilization conditions for long-term storage of bacteriophages. 2019. In Scientific Reports 9(1): 1-10.
• Manohar P, Tamhankar AJ, Lundborg CS, Nachimuthu R. Therapeutic characterization and efficacy of bacteriophage cocktails infecting Escherichia coli, Klebsiella pneumoniae and Enterobacter species. 2019. In Frontiers in Microbiology 10: 574.
• Manohar P, Tamhankar AJ, Cecilia SL, Ramesh N. Isolation, characterization and in vivo efficacy of Escherichia phage myPSH1131. 2018. In PLoS ONE 13(10): e0206278.
• Manohar P, Tamhankar AJ, Leptihn S, Ramesh N. Pharmacological and immunological aspects of phage therapy. 2019. In Infectious Microbes & Diseases 1(2): 34-42.
• Archana L, Manohar P, Eniyan K, Jayaraj R, N Ramesh. Evaluation of various phenotypic methods with genotypic screening for detection of methicillin-resistant Staphylococcus aureus. 2019. In Asian Biomedicine 13(6): 225-233.
• De S, Chaudhuri SR, Panda A, Jadhav GR, Kumar RS, Manohar P, Ramesh N et al. Synthesis, characterisation, molecular docking, biomolecular interaction and cytotoxicity studies of novel ruthenium (ii)–arene-2-heteroarylbenzoxazole complexes. 2019. In New Journal of Chemistry 43: 3291-3302.
• Shanthini T, Manohar P, Samna S, Srividya R, Bozdogan B, Rameshpathy M, Ramesh N. Emergence of plasmid-borne blaoxa-181 gene in Ochrobactrum intermedium: first report from India. 2019. In Access Microbiology 1(3): e000024.
• Ramesh N, Archana L, Royam MM, Manohar P, Eniyan K. Effect of various bacteriological media on the plaque morphology of Staphylococcus and Vibrio phages. 2019. In Access Microbiology, 1(4): e000036.
• Manohar P, Ramesh N, Lopes BS. The therapeutic potential of bacteriophages targeting Gram-negative bacteria using Galleria mellonella infection model. 2018. In BMC Microbiology 18: 97.
• Ravi A, Avershina E, Angell IL, Ludvigsen J, Manohar P, Padmanaban S, Nachimuthu R, Snipen L, Rudi K. Comparison of reduced metagenome and 16S rRNA gene sequencing for determination of genetic diversity and mother-child overlap of the gut associated microbiota. 2018. In Journal of Microbiological Methods 149: 44-52.
• Manohar P, Thamaraiselvan S, Babu S, Bozdogan B, Nachimuthu R. Identification of blaDIM-1 metallo beta-lactamase in Pseudomonas aeruginosa isolated From Tamil Nadu, India. 2018. In Journal of Global Antimicrobial Resistance 13: 7-8.
• Manohar P, Shanthini T, Ekta P, Gothandam KM, Bozdogan B, Ramesh N. Colistin-resistant Klebsiella pneumoniae: prevalence of integrons and synergistic out turn for colistin-meropenem. 2018. In Archives of Clinical Infectious Diseases 13(1): e55099.
• Manohar P, Shanthini T, Marathe N, Jadhav S, Slathia S, Thomson M, Jacob J, Bozdogan B, Nachimuthu R. Genetic Characteristics of Plasmid-Mediated Extended Spectrum Beta-Lactamases and Its Coexistence with NDM-1 in Clinical Gram-negative Bacteria. 2017. In Indian Journal of Biotechnology 16(2): 189-194.
• Choudhary R, Manohar P, Vecstaudza J, Yáñez-Gascón MJ, Sánchez HP, Nachimuthu R, Locs J, Swamiappan S. Preparation of nanocrystalline forsterite by combustion of different fuels and their comparative in-vitro bioactivity, dissolution behaviour and antibacterial studies. 2017. In Materials Science and Engineering C 77: 811–822.
• Manohar P, Shanthini T, Ayyanar R, Bozdogan B, Wilson A, Tamhankar AJ, Ramesh N. The distribution of carbapenem- and colistin- resistance in Gram-negative bacteria from Tamil Nadu region in India. 2017. In Journal of Medical Microbiology 66: 874-883.
• Ramesh N, Prasanth M, Ramkumar S, Suresh M, Tamhankar AJ, Gothandam KM, Karthikeyan S, Bozdogan B. Colistin susceptibility of Gram-negative clinical isolates in Tamil Nadu, India. 2016. In Asian Biomedicine 10(1): 1-3.
• Nachimuthu R, Subramani R, Maray S, Gothandam KM, Sivamangala K, Manohar P, Bozdogan B. Characterization of carbapenem resistant Gram negative bacteria from Tamil Nadu. 2016. In Journal of Chemotherapy 28(5): 371-374.
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