Olivia Lenoir INSERM
1 protocol

Carole Henique Institut Mondor de Recherche Biomédicale , Inserm U955/University Paris Est Créteil, France
1 protocol

Pierre-Louis Tharaux
  • Institut National de la Santé et de la Recherche Médicale
  • 1 Author merit

Education

M.D., PhD, Université Paris 6, France, 2000

Current position

Inserm Research Professor, PAris Cariovascular Center, Inserm U970, France

Publications

  1. Czopek A, Moorhouse R, Guyonnet L, Farrah T, Lenoir O, Owen E, van Bragt J, Costello HM, Menolascina F, Baudrie V, Webb DJ, Kluth DC, Bailey MA, Tharaux PL, Dhaun N. A novel role for myeloid endothelin-B receptors in hypertension. Eur Heart J. 2019 Mar 1;40(9):768-784. 
  2. Matte A, Recchiuti A, Federti E, Koehl B, Mintz T, El Nemer W, Tharaux PL, Brousse V, Andolfo I, Lamolinara A, Weinberg O, Siciliano A, Norris PC, Riley IR, Iolascon A, Serhan CN, Brugnara C, De Franceschi L. Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1. Blood. 2019 Jan 17;133(3):252-265. 
  3. Zeboudj L, Giraud A, Guyonnet L, Zhang Y, Laurans L, Esposito B, Vilar J, Chipont A, Papac-Milicevic N, Binder CJ, Tedgui A, Mallat Z, Tharaux PL, Ait-Oufella H Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis-Brief Report. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):114-119. 
  4. Lenoir O, Gaillard F, Lazareth H, Robin B, Tharaux PL. Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries. J Diabetes Res. 2017;2017:9603924. 
  5. Luque Y, Lenoir O, Bonnin P, Hardy L, Chipont A, Placier S, Vandermeersch S, Xu-Dubois YC, Robin B, Lazareth H, Souyri M, Guyonnet L, Baudrie V, Camerer E, Rondeau E, Mesnard L, Tharaux PL. Endothelial Epas1 Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension. J Am Soc Nephrol. 2017 Dec;28(12):3563-3578. 
  6. Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism. Sourdon J, Lager F, Viel T, Balvay D, Moorhouse R, Bennana E, Renault G, Tharaux PL, Dhaun N, Tavitian B. Theranostics. 2017 Jul 8;7(11):2757-2774. 
  7. Henique C, Bollée G, Loyer X, Grahammer F, Dhaun N, Camus M, Vernerey J, Guyonnet L, Gaillard F, Lazareth H, Meyer C, Bensaada I, Legrès L, Satoh T, Akira S, Bruneval P, Dimmeler S, Tedgui A, Karras A, Thervet E, Nochy D, Huber TB, Mesnard L, Lenoir O, Tharaux PL. Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Nat Commun. 2017 Nov 28;8(1):1829 
  8. Zschiedrich S, Bork T, Liang W, Wanner N, Eulenbruch K, Munder S, Hartleben B, Kretz O, Gerber S, Simons M, Viau A, Burtin M, Wei C, Reiser J, Herbach N, Rastaldi MP, Cohen CD, Tharaux PL, Terzi F, Walz G, Gödel M, Huber TB.Targeting mTOR Signaling Can Prevent the Progression of FSGS. J Am Soc Nephrol. 2017 Jul;28(7):2144-2157 
  9. Koehl B, Nivoit P, El Nemer W, Lenoir O, Hermand P, Pereira C, Brousse V, Guyonnet L, Ghinatti G, Benkerrou M, Colin Y, Le Van Kim C, Tharaux PL. The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease. Haematologica. 2017 Jul;102(7):1161-1172 
  10. Sonneveld R, Hoenderop JG, Isidori AM, Henique C, Dijkman HB, Berden JH, Tharaux PL, van der Vlag J, Nijenhuis T. Sildenafil prevents podocyte injury via PPAR-γ mediated TRPC6 inhibition. J Am Soc Nephrol. 2017 May;28(5):1491-1505. 
  11. Garsen M, Lenoir O, Rops AL, Dijkman HB, Willemsen B, van Kuppevelt TH, Rabelink TJ, Berden JH, Tharaux PL, van der Vlag J. Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx. J Am Soc Nephrol. 2016 Dec;27(12):3545-3551 
  12. Lenoir O, Jasiek M, Henique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, Massé JM, Souyri M, Huber TB, Tharaux PL. Endothelial cell- and Podocyte Autophagy Synergistically protect from Diabetes-induced Glomerulosclerosis. Autophagy. 2015;11(7):1130-45. 
  13. Henique C, Bollee G, Lenoir O, Dhaun N, Camus M, Chipont A, Flosseau K, Mandet C, Yamamoto M, Karras A, , Thervet E, Bruneval P, Nochy D, Mesnard L, Tharaux PL. NRF2 Drives Podocyte-Specific PPARg Expression that Is Essential to Promotes Resistance to Crescentic Glomerulonephritis. Proof of Principle for Potential Therapy. J Am Soc Nephrol. 2016 Jan;27(1):172-88. 
  14. Henique C, Papista C, Guyonnet L, Lenoir O, Tharaux PL. Update on crescentic glomerulonephritis. Semin Immunopathol. 2014 Jul;36(4):479-90. 
  15. Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med. 2011 Sep 25;17(10):1242-50.
1 Protocol published
Immunofluorescence Staining of WT-1/Podocalyxin on Mouse Kidney Sections
Authors:  Carole Henique, Olivia Lenoir and Pierre-Louis Tharaux, date: 04/20/2019, view: 356, Q&A: 0
In glomerular diseases, podocytes are one type of cells involved in dysfunction of glomerular filtration. In these conditions, podocyte proteins expression change. Therefore, immunofluorescent staining of podocytes can be performed to visualize ...
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