Search

Cindy L. Linn
  • Faculty, Western Michigan University
Research focus
  • Neuroscience
  • I am a retinal neurobiologist examining neuroprotection and neurogenesis in the adult mammalian retina resulting from activation of alpha7 nicotinic acetylcholine receptors.

Education

PhD, Rice University, 1991

Lab information

Cindy Linn's Lab
http://www.wmich.edu/biology/directory/linn

Publications

Wang-Bennett, L.T., C.L. Pfeiffer, J. Arnold and R.M. Glantz. 1989. Acetylcholine in the crayfish optic lobe: Concentration profile and cellular localization. J. Neurosci. 9(6): 1864-1871.

Pfeiffer, C.L. and R.M. Glantz. 1989. Cholinergic synapses and the organization of contrast detection in the crayfish optic lobe. J. Neurosci. 9(6): 1872-1882.

Pfeiffer-Linn, C. and R.M. Glantz. 1989. Acetylcholine and GABA mediate opposing actions on neuronal chloride channels in crayfish. Science. 245: 1249-1251.

Pfeiffer-Linn, C. and R.M. Glantz. 1990. A neuronal nicotinic acetylcholine receptor in crayfish neurons. Neurosci. Lett. 120: 234-236.

Pfeiffer-Linn, C. and R.M. Glantz. 1991. GABA mediated inhibition of visual interneurons in the crayfish medulla. J. Comp. Physiol. 168: 373-381.

Pfeiffer-Linn, C.L. and R.M. Glantz. 1991. An arthropod NMDA receptor. Synapse. 9: 35-42.

Linn, C.L. and B.N. Christensen. 1992. Excitatory amino acid regulation of intracellular calcium in isolated catfish cone horizontal cells measured under voltage and concentration clamp condition. J. Neurosci. 12(6): 2156-2164.

Glantz, R.M. and C. Pfeiffer-Linn. 1992. NMDA receptors in invertebrates. Comp. Biochem. Physiol. 103(C): 243-248.

Pfeiffer-Linn, C.L. and E.M. Lasater. 1993. Dopamine modulates in a differential fashion T- and L- type calcium currents in bass retinal horizontal cells. J. Gen. Physiol. 102: 277-294.

Pfeiffer-Linn, C.L., I. Perlman and E.M. Lasater. 1995. Sodium dependency of the inward potassium rectifier in horizontal cells isolated from the white bass retina. Brain Res. 701: 81-88. PMID: 8925302

Pfeiffer-Linn, C.L. and E.M. Lasater. 1996. Whole-cell and single-channel properties of a unique voltage-activated sustained calcium current identified in teleost retinal horizontal cells. J. Neurophysiol. 75: 609-619. PMID: 8714638

Pfeiffer-Linn, C.L. and E.M. Lasater. 1996. Dopamine modulates the unitary conductance and kinetic properties of a PL-type sustained calcium channel in retinal horizontal cells. J. Physiol. 496: 607-616. PMID: 8930829

Pfeiffer-Linn, C.L. and E.M. Lasater. 1998. Multiple second messenger system modulation of voltage-dependent calcium current identified in a teleost retinal horizontal cell. J. Neurophysiol. 80: 377-388. PMID: 9658058

Linn, C.L. and A.C. Gafka. 1999. Activation of metabotropic glutamate receptors modulates a voltage-gated sustained calcium current in a teleost horizontal cell. J. Neurophysiol. 81:425-434. PMID: 10036249

Gafka, A.C., K.S. Vogel and C.L. Linn. 1999. Evidence of metabotropic glutamate receptor subtypes found on catfish horizontal and bipolar retinal neurons. Neurosci. 90: 1403-1414. PMID: 10338307

Linn, C.L. 2000. Second messenger pathway involved in up-regulation of an L-type calcium channel. Vis. Neurosci. 17: 473-482. PMID: 10910113

Linn, C.L. and A.C. Gafka. 2001. Modulation of a voltage-gated calcium channel linked to an ionotropic glutamate receptor and calcium-induced calcium release. J. Physiol. 535: 47-63. PMID: 11507157

Davis, S.F. and C.L. Linn. 2002. Activation of NMDA receptors linked to modulation of voltage-gated ion channels and functional implications. E-pub 2002. Am. J. Physiol. Cell Physiol. 2003, 284: C757-C768. PMID: 12456395

Davis, S.F. and C.L. Linn. 2003. Mechanism linking NMDA receptor activation to modulation of a voltage-gated sodium current in the distal retina. Am. J. Physiol. Cell Physiol. 284: C1193-C1204. PMID: 12676655

Wehrwein, E., S.A. Thompson, S.F. Coulibaly, D.M. Linn and C.L. Linn. 2004. Acetylcholine protects isolated adult pig retinal ganglion cells from glutamate-induced excitotoxicity. IOVS. 45 (5): 1531-1543. PMID: 15111612

Derbenev, A.V., C.L. Linn and P.S. Guth. 2005. Muscarinic ACh receptor activation causes transmitter release from isolated frog vestibular hair cells. J. Neurophysiol. 94: 3134-3142. PMID: 16222072

Thompson, S.A., O. Smith, D.M. Linn and C.L. Linn. 2006. ACh neuroprotection against glutamate-induced excitotoxicity in adult pig RGCs is partially mediated through alpha4 nAChRs. Exp. Eye Res. 83 (5): 1135-1145. PMID: 16928373

Asomugha C, Linn, D.M., Linn CL. 2010 ACh receptors link two signaling pathways to neuroprotection against glutamate-induced excitotoxicity in isolated pig RGCs. J. Neurochem. 112: 214-226. PMID: 19845831

Brandt S, Weatherly M, Lillian Ware, Linn DM, Linn CL. 2011 Calcium preconditioning triggers neuroprotection in the retina. Neurosci. 172: 387-397.

Iwamoto K, Linn DM, Mata, D., Linn CL. 2013. Neuroprotection of rat retinal ganglion cells mediated through alpha7 nicotinic acetylcholine receptors. Neurosci. 237: 184-198.

Swartz, M., Linn DM, Linn, CL. 2013. Tropisetron as a Neuroprotective Agent Against Glutamate-Induced Excitotoxicity and Mechanisms of Action. Neuropharm. 73: 111-121.

Iwamoto K, Birkholtz P, Schipper A, Mata D, Linn DM, Linn CL. 2014. A nicotinic acetylcholine receptor agonist prevents loss of retinal ganglion cells in a glaucoma model. IOVS. 55(2): 1078-1087.

Mata D, Linn DM, Linn CL. 2015. Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors. Neuropharm. 99: 337-346.

Gossman C, Linn DM, Linn CL. 2016. Glaucoma-inducing procedure in an in vivo rat model and whole-mount retina preparation. J. Vis. Exp. 109: e53831.

Gossman AC, Christie J, Webster MK, Linn DL, Linn CL. 2016. Neuroprotective strategies in glaucoma. Curr. Pharmacol. Des. 22:1-15.

Birkholz PJ, Gossman CA, Webster MK, Linn DM, Linn CL. 2016. Prevention of glaucoma-induced retinal ganglion cell loss using alpha7 nAChR agonists. J. Ophthal. Vis. Sci. 1(1): e1003.

Linn CL. 2016. Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors. Neural Regen. Res. 11:918-919.

Webster MK, Cooley-Themm CA, Barnett J, Bach HB, Vannier J, Webster S, Linn CL. 2017. Evidence of BrdU Positive Retinal Neurons after Application of an Alpha7 Nicotinic Acetylcholine Receptor Agonist. Neurosci. 346: 437-446.

Cooley-Themm CA, Ameel Q, Linn DM, Linn CL. 2017. Loss of Displaced Starburst Amacrine cells in a Rat Glaucoma Model. Sci.Pages of Ophthal. 1: 28-38.

Linn CL. 2018. Neuroprotection And/Or Neurogenesis: Effect Of An Alpha7 nAChR Agonist In The Adult Mammalian Retina. J. Ophthal. Vis. Sci. 3(1):1025.