Simon Grelet
  • Assistant Professor, University of South Alabama - Mitchell Cancer Institute
Research focus
  • Biochemistry
  • Molecular Oncology
    Experimental Oncology
    Tumor Biology
    Cancer Cell Biology
    Epithelial-Mesenchymal Transition
    Cancer Metabolism
    Cell Signaling
    Cancer Biomarkers
    Tumor Microenvironment
    RNA Biology
    Alternative Splicing
    tRNA biology


PhD in Cell Biology and Biochemistry, Université de Reims Champagne-Ardenne, France, 2014


Simon Grelet, Philip H. Howe
hnRNP E1 at the crossroads of translational regulation of epithelial-mesenchymal transition.
Journal Of Cancer Metastasis Treatment 2019.

Alec N. Woosley, Annamarie C. Dalton, George S. Hussey, Breege V. Howley, Bidyut K. Mohanty, Simon Grelet, Toros Dincman, Sean Bloos, Shaun K. Olsen, Philip H. Howe
TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis.
Oncogene 2019.

Simon Grelet, Renaud Geslain, Philip H. Howe
EMT does not work regular shifts.
Cell cycle 2018.

Breege V. Howley, Laura A. Link, Simon Grelet, Maya El-Sabban, Philip H. Howe
A CREB3-regulated ER–Golgi trafficking signature promotes metastatic progression in breast cancer.
Oncogene 2017

Simon Grelet, Laura A Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy, Vamsi K Gangaraju, J Alan Diehl, Philip H Howe
A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
Nature Cell Biology 2017.

Simon Grelet, Ariel McShane, Renaud Geslain, Philip H. Howe
Pleiotropic Roles of Non-Coding RNAs in TGF-β-Mediated Epithelial-Mesenchymal Transition and Their Functions in Tumor Progression.
Cancers 2017.

Simon Grelet, Ariel McShane, Eveline Hok, Jensen Tomberlin, Philip H. Howe, Renaud Geslain
SPOt: A novel and streamlined microarray platform for observing cellular tRNA levels.
PLoS ONE 2017.

Julien Lesage, Meggy Suarez-Carmona, Deborah Neyrinck-Leglantier, Simon Grelet, Silvia Blacher, Walter Hunziker, Philippe Birembaut, Agnes Noël, Béatrice Nawrocki-Raby, Christine Gilles, Myriam Polette
Zonula occludens-1/NF-κB/CXCL8: A new regulatory axis for tumor angiogenesis.
The FASEB Journal 2017.

Simon Grelet, Vanessa Andries, Myriam Polette, Christine Gilles, Katrien Staes, Anne-Pascaline Martin, Claire Kileztky, Christine Terryn, Véronique Dalstein, Chun-Wen Cheng, Chen-Yang Shen, Philippe Birembaut, Frans Van Roy, Béatrice Nawrocki-Raby
The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition: Nanos3 induces EMT-associated lung tumour invasion.
The Journal of Pathology 2015.

J. Lesage, S. Grelet, B. Nawrocki-Raby, P. Birembaut, C. Gilles, M. Polette
Régulation de l’interleukine-8 par les ZOs : un mécanisme dépendant de NF-κB.
Revue des Maladies Respiratoires 2015.

Kahina Medjber, Mohamed Lamine Freidja, Simon Grelet, Marianne Lorenzato, Kamel Maouche, Béatrice Nawrocki-Raby, Philippe Birembaut, Myriam Polette, Jean-Marie Tournier
Role Of Nicotinic Acetylcholine Receptors In Cell Proliferation And Tumour Invasion In Broncho-Pulmonary Carcinomas.
Lung cancer 2015.

E. De Keuckelaere, V. Andries, K. Staes, S. Grelet, B. Nawrocki-Raby, P. Birembaut, F. Van Roy
Role of NANOS family members in tumor progression.
European Journal of Cancer 2014.

Audrey Joannes, Simon Grelet, Laurent Duca, Christine Gilles, Claire Kileztky, Veronique Dalstein, Philippe Birembaut, Myriam Polette, Beatrice Nawrocki-Raby
Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.
Molecular Cancer Research 2014.
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