Kathleen O'Connor 1 protocol

Jianrong Wu 1 protocol

Piotr Rychahou Surgery/MCC, University of Kentucky, 2009-2020
1 protocol

Dava Piecoro 1 protocol

Min Chen
  • Assistant Professor, Department of Toxicology and Cancer Biology, University of Kentucky, 2013-2020
Research focus
  • -
  • 1 Author merit

Education

PhD, University of Texas Medical Branch, USA, 2011

Publications

• Huang, X., Ye, Q., Chen, M., Li, A., Mi, W., Fang, Y., Zaytseva, Y. Y., O'Connor, K. L., Vander Kooi, C. W., Liu, S. and She, Q. B. (2019). N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Nat Commun 10(1): 3708.
• Liu, L., Qi, L., Knifley, T., Piecoro, D. W., Rychahou, P., Liu, J., Mitov, M. I., Martin, J., Wang, C., Wu, J., Weiss, H. L., Butterfield, D. A., Evers, B. M., O'Connor, K. L. and Chen, M. (2019). S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2. J Biol Chem 294(18): 7516-7527.
• Stewart, R. L., Carpenter, B. L., West, D. S., Knifley, T., Liu, L., Wang, C., Weiss, H. L., Gal, T. S., Durbin, E. B., Arnold, S. M., O'Connor, K. L. and Chen, M. (2016). S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide. Oncotarget 7(23): 34630-34642.
• Stewart, R. L., Carpenter, B. L., West, D. S., Knifley, T., Liu, L., Wang, C., Weiss, H. L., Gal, T. S., Durbin, E. B., Arnold, S. M., O'Connor, K. L. and Chen, M. (2016). S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide. Oncotarget 7(23): 34630-34642.
• Carpenter, B. L., Chen, M., Knifley, T., Davis, K. A., Harrison, S. M., Stewart, R. L. and O'Connor, K. L. (2015). Integrin alpha6beta4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF). J Biol Chem 290(45): 27228-27238.
• Chen, M., Knifley, T., Subramanian, T., Spielmann, H. P. and O'Connor, K. L. (2014). Use of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasion. PLoS One 9(2): e89892.
• Harrison, S. M., Knifley, T., Chen, M. and O'Connor, K. L. (2013). LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells. BMC Cancer 13: 501.
• O'Connor, K. and Chen, M. (2013). Dynamic functions of RhoA in tumor cell migration and invasion. Small GTPases 4(3): 141-147.
• Chen, M., Bresnick, A. R. and O'Connor, K. L. (2013). Coupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells. Oncogene 32(32): 3754-3764.
• O'Connor, K. L., Chen, M. and Towers, L. N. (2012). Integrin alpha6beta4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. Am J Physiol Cell Physiol 302(3): C605-614.
• Chen, M., Sastry, S. K. and O'Connor, K. L. (2011). Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells. Am J Physiol Cell Physiol 300(5): C1155-1163.
• Gulhati, P., Bowen, K. A., Liu, J., Stevens, P. D., Rychahou, P. G., Chen, M., Lee, E. Y., Weiss, H. L., O'Connor, K. L., Gao, T. and Evers, B. M. (2011). mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71(9): 3246-3256.
• Chen, M., Sinha, M., Luxon, B. A., Bresnick, A. R. and O'Connor, K. L. (2009). Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. J Biol Chem 284(3): 1484-1494.
• Chen, M., Towers, L. N. and O'Connor, K. L. (2007). LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells. Am J Physiol Cell Physiol 292(5): C1927-1933.
• Chen, M. and O'Connor, K. L. (2005). Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene 24(32): 5125-5130.
• Gosslau, A., Chen, M., Ho, C. T. and Chen, K. Y. (2005). A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts. Br J Cancer 92(3): 513-521.
• Tian, Y., Ke, S., Chen, M. and Sheng, T. (2003). Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter. J Biol Chem 278(45): 44041-44048.
• Chen, M., Zhang, J. Z. and Bi, D. Z. (2000). Studies on the phylogenetic relationship between HL-93 strain and HL J-054 strain of SFGR. Chin J Zoonoses 16(3):12-16.
• Chen, M., Fan, M. Y. and Bi, D. Z. (1998). Detection, isolation and identification of spotted fever group rickettsiae from Ninghua county of Fujian Province. Chin J Microbiol Immunol 17(6):433- 437.
• Chen, M., Fan, M., Bi, D. and Zhang, J. (1998). [Cloning and sequence analysis of rOmpA gene fragment of spotted fever group Rickettsiae isolated in China]. Wei Sheng Wu Xue Bao 38(4): 276-282.
• Chen, M., Fan, M. Y., Bi, D. Z., Zhang, J. Z. and Chen, X. R. (1998). Sequence analysis of a fragment of rOmpA gene of several isolates of spotted fever group rickettsiae from China. Acta Virol 42(2): 91-93.
• Chen, M., Fan, M. Y., Bi, D. Z., Zhang, J. Z. and Huang, Y. P. (1998). Detection of Rickettsia sibirica in ticks and small mammals collected in three different regions of China. Acta Virol 42(1): 61-64.
• Chen, M., Fan, M. Y. and Xu, G. M. (1997). [Detection of north-Asia tick-borne spotted fever in ticks and rodents along the Heilongjiang river-side by restriction fragment length polymorphism of PCR products]. Zhonghua Liu Xing Bing Xue Za Zhi 18(1): 5-7.
• Chen, M., Fan, M. Y. and Bi, D. Z. (1997). [A molecular epidemiologic investigation of north Asia fever in scenic spots of Beijing suburb]. Zhonghua Liu Xing Bing Xue Za Zhi 18(4): 197-200.
1 Protocol published
In vivo Tumor Growth and Spontaneous Metastasis Assays Using A549 Lung Cancer Cells
Metastasis accounts for the majority of cancer related deaths. The genetically engineered mouse (GEM) models and cell line-based subcutaneous and orthotopic mouse xenografts have been developed to study the metastatic process. By using lung cancer ...
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