Tullio Florio 1 protocol

Alessandra Pattarozzi Internal Medicine, Pharmacology Unit, University of Genova, Italy
1 protocol

Roberto Würth 1 protocol

Federica Barbieri
  • Internal Medicine, Pharmacology Unit, University of Genova, Italy
  • 1 Author merit

Education

PhD., Università degli Studi di Genova, Italy, 1998-2001

Current position

Professor of Pharmacology, Department of Internal Medicine, Università degli Studi di Genova, Italy, 2017

Publications (since 2008)

  1. Baldassari, S., Solari, A., Zuccari, G., Drava, G., Pastorino, S., Fucile, C., Marini, V., Daga, A., Pattarozzi, A., Ratto, A., Ferrari, A., Mattioli, F., Barbieri, F., Caviglioli, G. and Florio, T. (2018). Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects. Sci Rep 8(1): 3929.
  2. Gatti, M., Solari, A., Pattarozzi, A., Campanella, C., Thellung, S., Maniscalco, L., De Maria, R., Wurth, R., Corsaro, A., Bajetto, A., Ratto, A., Ferrari, A., Daga, A., Barbieri, F. and Florio, T. (2018). In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity. Exp Cell Res 363(1): 48-64.
  3. Bajetto, A., Pattarozzi, A., Corsaro, A., Barbieri, F., Daga, A., Bosio, A., Gatti, M., Pisaturo, V., Sirito, R. and Florio, T. (2017). Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors. Front Cell Neurosci 11: 312.
  4. Pattarozzi, A., Carra, E., Favoni, R. E., Wurth, R., Marubbi, D., Filiberti, R. A., Mutti, L., Florio, T., Barbieri, F. and Daga, A. (2017). The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells. Stem Cell Res Ther 8(1): 119.
  5. Mohamed, A., Romano, D., Saveanu, A., Roche, C., Albertelli, M., Barbieri, F., Brue, T., Niccoli, P., Delpero, J. R., Garcia, S., Ferone, D., Florio, T., Moutardier, V., Poizat, F., Barlier, A. and Gerard, C. (2017). Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs? Oncotarget 8(25): 41044-41063.
  6. Angeletti, F., Fossati, G., Pattarozzi, A., Wurth, R., Solari, A., Daga, A., Masiello, I., Barbieri, F., Florio, T. and Comincini, S. (2016). Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells. Front Mol Neurosci 9: 107.
  7. Corsaro, A., Bajetto, A., Thellung, S., Begani, G., Villa, V., Nizzari, M., Pattarozzi, A., Solari, A., Gatti, M., Pagano, A., Wurth, R., Daga, A., Barbieri, F. and Florio, T. (2016). Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells. Oncotarget 7(25): 38638-38657.
  8. Barbieri, F., Bajetto, A., Thellung, S., Wurth, R. and Florio, T. (2016). Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma. Expert Opin Drug Discov 11(11): 1093-1109.
  9. Wurth, R., Barbieri, F., Pattarozzi, A., Gaudenzi, G., Gatto, F., Fiaschi, P., Ravetti, J. L., Zona, G., Daga, A., Persani, L., Ferone, D., Vitale, G. and Florio, T. (2017). Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas. Mol Neurobiol 54(7): 4879-4895.
  10. Gatti, M., Wurth, R., Vito, G., Pattarozzi, A., Campanella, C., Thellung, S., Maniscalco, L., De Maria, R., Villa, V., Corsaro, A., Nizzari, M., Bajetto, A., Ratto, A., Ferrari, A., Barbieri, F. and Florio, T. (2016). Canine osteosarcoma cell lines contain stem-like cancer cells: biological and pharmacological characterization. Jpn J Vet Res 64(2): 101-112.
  11. Gaudenzi, G., Albertelli, M., Dicitore, A., Wurth, R., Gatto, F., Barbieri, F., Cotelli, F., Florio, T., Ferone, D., Persani, L. and Vitale, G. (2017). Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors. Endocrine 57(2): 214-219.
  12. Banelli, B., Carra, E., Barbieri, F., Wurth, R., Parodi, F., Pattarozzi, A., Carosio, R., Forlani, A., Allemanni, G., Marubbi, D., Florio, T., Daga, A. and Romani, M. (2015). The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma. Cell Cycle 14(21): 3418-3429.
  13. Wurth, R., Thellung, S., Bajetto, A., Mazzanti, M., Florio, T. and Barbieri, F. (2016). Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds. Drug Discov Today 21(1): 190-199.
  14. Thellung, S., Favoni, R. E., Wurth, R., Nizzari, M., Pattarozzi, A., Daga, A., Florio, T. and Barbieri, F. (2016). Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies. Curr Drug Targets 17(7): 824-849.
  15. Barbieri, F., Thellung, S., Ratto, A., Carra, E., Marini, V., Fucile, C., Bajetto, A., Pattarozzi, A., Wurth, R., Gatti, M., Campanella, C., Vito, G., Mattioli, F., Pagano, A., Daga, A., Ferrari, A. and Florio, T. (2015). In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors. BMC Cancer 15: 228.
  16. Barbieri, F., Thellung, S., Wurth, R., Gatto, F., Corsaro, A., Villa, V., Nizzari, M., Albertelli, M., Ferone, D. and Florio, T. (2014). Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System. Int J Endocrinol 2014: 753524.
  17. Gritti, M., Wurth, R., Angelini, M., Barbieri, F., Peretti, M., Pizzi, E., Pattarozzi, A., Carra, E., Sirito, R., Daga, A., Curmi, P. M., Mazzanti, M. and Florio, T. (2014). Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current. Oncotarget 5(22): 11252-11268.
  18. Mohamed, A., Blanchard, M. P., Albertelli, M., Barbieri, F., Brue, T., Niccoli, P., Delpero, J. R., Monges, G., Garcia, S., Ferone, D., Florio, T., Enjalbert, A., Moutardier, V., Schonbrunn, A., Gerard, C., Barlier, A. and Saveanu, A. (2014). Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures. Endocr Relat Cancer 21(5): 691-704.
  19. Wurth, R., Bajetto, A., Harrison, J. K., Barbieri, F. and Florio, T. (2014). CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment. Front Cell Neurosci 8: 144.
  20. Porcile, C., Di Zazzo, E., Monaco, M. L., D'Angelo, G., Passarella, D., Russo, C., Di Costanzo, A., Pattarozzi, A., Gatti, M., Bajetto, A., Zona, G., Barbieri, F., Oriani, G., Moncharmont, B., Florio, T. and Daniele, A. (2014). Adiponectin as novel regulator of cell proliferation in human glioblastoma. J Cell Physiol 229(10): 1444-1454.
  21. Wurth, R., Barbieri, F. and Florio, T. (2014). New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells. Biomed Res Int 2014: 126586.
  22. Barbieri, F., Albertelli, M., Grillo, F., Mohamed, A., Saveanu, A., Barlier, A., Ferone, D. and Florio, T. (2014). Neuroendocrine tumors: insights into innovative therapeutic options and rational development of targeted therapies. Drug Discov Today 19(4): 458-468.
  23. Gatti, M., Pattarozzi, A., Bajetto, A., Wurth, R., Daga, A., Fiaschi, P., Zona, G., Florio, T. and Barbieri, F. (2013). Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity. Toxicology 314(2-3): 209-220.
  24. Vitale, R. M., Gatti, M., Carbone, M., Barbieri, F., Felicita, V., Gavagnin, M., Florio, T. and Amodeo, P. (2013). Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of phidianidine a as a new CXCR4 ligand exhibiting antagonist activity. ACS Chem Biol 8(12): 2762-2770.
  25. Bajetto, A., Porcile, C., Pattarozzi, A., Scotti, L., Aceto, A., Daga, A., Barbieri, F. and Florio, T. (2013). Differential role of EGF and BFGF in human GBM-TIC proliferation: relationship to EGFR-tyrosine kinase inhibitor sensibility. J Biol Regul Homeost Agents 27(1): 143-154.
  26. Barbieri, F., Bajetto, A., Pattarozzi, A., Gatti, M., Wurth, R., Thellung, S., Corsaro, A., Villa, V., Nizzari, M. and Florio, T. (2013). Peptide receptor targeting in cancer: the somatostatin paradigm. Int J Pept 2013: 926295.
  27. Carra, E., Barbieri, F., Marubbi, D., Pattarozzi, A., Favoni, R. E., Florio, T. and Daga, A. (2013). Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures. Cell Cycle 12(3): 491-500.
  28. Wurth, R., Pattarozzi, A., Gatti, M., Bajetto, A., Corsaro, A., Parodi, A., Sirito, R., Massollo, M., Marini, C., Zona, G., Fenoglio, D., Sambuceti, G., Filaci, G., Daga, A., Barbieri, F. and Florio, T. (2013). Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt. Cell Cycle 12(1): 145-156.
  29. Florio, T. and Barbieri, F. (2012). The status of the art of human malignant glioma management: the promising role of targeting tumor-initiating cells. Drug Discov Today 17(19-20): 1103-1110.
  30. Ferrari, A., Petterino, C., Ratto, A., Campanella, C., Wurth, R., Thellung, S., Vito, G., Barbieri, F. and Florio, T. (2012). CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis. BMC Vet Res 8: 27.
  31. Ratto, A., Petterino, C., Florio, T. and Barbieri, F. (2012). Goat anti-human GM-CSF recognizes canine GM-CSF. Vet Clin Pathol 41(1): 3-4.
  32. Barbieri, F., Wurth, R., Ratto, A., Campanella, C., Vito, G., Thellung, S., Daga, A., Cilli, M., Ferrari, A. and Florio, T. (2012). Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential. Exp Cell Res 318(7): 847-860.
  33. Nizzari, M., Barbieri, F., Gentile, M. T., Passarella, D., Caorsi, C., Diaspro, A., Taglialatela, M., Pagano, A., Colucci-D'Amato, L., Florio, T. and Russo, C. (2012). Amyloid-beta protein precursor regulates phosphorylation and cellular compartmentalization of microtubule associated protein tau. J Alzheimers Dis 29(1): 211-227.
  34. Gatto, F., Barbieri, F., Gatti, M., Wurth, R., Schulz, S., Ravetti, J. L., Zona, G., Culler, M. D., Saveanu, A., Giusti, M., Minuto, F., Hofland, L. J., Ferone, D. and Florio, T. (2012). Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogues and dopastatins. Clin Endocrinol (Oxf) 76(3): 407-414.
  35. Barbieri, F., Wurth, R., Favoni, R. E., Pattarozzi, A., Gatti, M., Ratto, A., Ferrari, A., Bajetto, A. and Florio, T. (2011). Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets. Biochem Pharmacol 82(10): 1467-1477.
  36. Giannoni, P., Scaglione, S., Quarto, R., Narcisi, R., Parodi, M., Balleari, E., Barbieri, F., Pattarozzi, A., Florio, T., Ferrini, S., Corte, G. and de Totero, D. (2011). An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease. Haematologica 96(7): 1015-1023.
  37. Wurth, R., Barbieri, F., Bajetto, A., Pattarozzi, A., Gatti, M., Porcile, C., Zona, G., Ravetti, J. L., Spaziante, R. and Florio, T. (2011). Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature. J Neuroimmunol 234(1-2): 115-123.
  38. Gatto, F., Barbieri, F., Castelletti, L., Arvigo, M., Pattarozzi, A., Annunziata, F., Saveanu, A., Minuto, F., Castellan, L., Zona, G., Florio, T. and Ferone, D. (2011). In vivo and in vitro response to octreotide LAR in a TSH-secreting adenoma: characterization of somatostatin receptor expression and role of subtype 5. Pituitary 14(2): 141-147.
  39. Massone, S., Vassallo, I., Fiorino, G., Castelnuovo, M., Barbieri, F., Borghi, R., Tabaton, M., Robello, M., Gatta, E., Russo, C., Florio, T., Dieci, G., Cancedda, R. and Pagano, A. (2011). 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease. Neurobiol Dis 41(2): 308-317.
  40. Rostene, W., Guyon, A., Kular, L., Godefroy, D., Barbieri, F., Bajetto, A., Banisadr, G., Callewaere, C., Conductier, G., Rovere, C., Melik-Parsadaniantz, S. and Florio, T. (2011). Chemokines and chemokine receptors: new actors in neuroendocrine regulations. Front Neuroendocrinol 32(1): 10-24.
  41. Favoni, R. E., Pattarozzi, A., Lo Casto, M., Barbieri, F., Gatti, M., Paleari, L., Bajetto, A., Porcile, C., Gaudino, G., Mutti, L., Corte, G. and Florio, T. (2010). Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. Curr Cancer Drug Targets 10(2): 176-191.
  42. Barbieri, F., Bajetto, A. and Florio, T. (2010). Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target. J Oncol 2010: 426956.
  43. Errico, F., Nistico, R., Napolitano, F., Oliva, A. B., Romano, R., Barbieri, F., Florio, T., Russo, C., Mercuri, N. B. and Usiello, A. (2011). Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay. Neurobiol Aging 32(11): 2061-2074.
  44. Barbieri, F., Pattarozzi, A., Gatti, M., Aiello, C., Quintero, A., Lunardi, G., Bajetto, A., Ferrari, A., Culler, M. D. and Florio, T. (2009). Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab 297(5): E1078-1088.
  45. Griffero, F., Daga, A., Marubbi, D., Capra, M. C., Melotti, A., Pattarozzi, A., Gatti, M., Bajetto, A., Porcile, C., Barbieri, F., Favoni, R. E., Lo Casto, M., Zona, G., Spaziante, R., Florio, T. and Corte, G. (2009). Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors. J Biol Chem 284(11): 7138-7148.
  46. Barbieri, F., Bajetto, A., Stumm, R., Pattarozzi, A., Porcile, C., Zona, G., Dorcaratto, A., Ravetti, J. L., Minuto, F., Spaziante, R., Schettini, G., Ferone, D. and Florio, T. (2008). Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas. Clin Cancer Res 14(16): 5022-5032.
  47. Barbieri, F., Pattarozzi, A., Gatti, M., Porcile, C., Bajetto, A., Ferrari, A., Culler, M. D. and Florio, T. (2008). Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2. Endocrinology 149(9): 4736-4746.
  48. Florio, T., Barbieri, F., Spaziante, R., Zona, G., Hofland, L. J., van Koetsveld, P. M., Feelders, R. A., Stalla, G. K., Theodoropoulou, M., Culler, M. D., Dong, J., Taylor, J. E., Moreau, J. P., Saveanu, A., Gunz, G., Dufour, H. and Jaquet, P. (2008). Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. Endocr Relat Cancer 15(2): 583-596.
  49. Pattarozzi, A., Gatti, M., Barbieri, F., Wurth, R., Porcile, C., Lunardi, G., Ratto, A., Favoni, R., Bajetto, A., Ferrari, A. and Florio, T. (2008). 17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment. Mol Pharmacol 73(1): 191-202.
1 Protocol published
Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas
Authors:  Roberto Würth, Alessandra Pattarozzi, Federica Barbieri and Tullio Florio, date: 04/05/2018, view: 1261, Q&A: 0
Pituitary adenomas are among the more frequent intracranial tumors usually treated with both surgical and pharmacological–based on somatostatin and dopamine agonists–approaches. Although mostly benign tumors, the occurrence of invasive behaviors is ...
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