Manuela Battaglia Diabetes Research Institute (DRI) , IRCCS San Raffaele Scientific Institute, Italy, Italy,
1 protocol

Nicola Gagliani Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Germany, Germany,
1 protocol

Gregori Silvia San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Italy, Italy,
1 protocol

Giuseppe Galvani Diabetes Research Institute (DRI) , IRCCS San Raffaele Scientific Institute, Italy, Italy,
1 protocol

Fousteri Georgia
  • Diabetes Research Institute (DRI) , IRCCS San Raffaele Scientific Institute, Italy, Italy,
Research focus
  • Immunology
  • 1 Author merit


PhD, University of Crete, Greece, 2006

Current position

Group Leader, Diabetes Research Institute, San Raffaele Scientific Institute, Italy


  1. Sebastiani, G., Ventriglia, G., Stabilini, A., Socci, C., Morsiani, C., Laurenzi, A., Nigi, L., Formichi, C., Mfarrej, B., Petrelli, A., Fousteri, G., Brusko, T. M., Dotta, F. and Battaglia, M. (2017). Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression. Sci Rep 7(1): 6897.
  2. Jofra, T., Galvani, G., Kuka, M., Di Fonte, R., Mfarrej, B. G., Iannacone, M., Salek-Ardakani, S., Battaglia, M. and Fousteri, G. (2017). Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. Front Immunol 8: 811.
  3. Jofra, T., Di Fonte, R., Hutchinson, T. E., Dastmalchi, F., Galvani, G., Battaglia, M., Salek-Ardakani, S. and Fousteri, G. (2017). Protein tyrosine phosphatase PTPN22 has dual roles in promoting pathogen versus homeostatic-driven CD8 T-cell responses. Immunol Cell Biol 95(2): 121-128.
  4. Gerosa, J., Lougaris, V., Baronio, M., Plebani, A., Cicalese, M. P. and Fousteri, G. (2017). Beta2 integrins are required for follicular helper T cell differentiation in humans. Clin Immunol 180: 60-62.
  5. Galvani, G. and Fousteri, G. (2017). PTPN22 and islet-specific autoimmunity: What have the mouse models taught us? World J Diabetes 8(7): 330-336.
  6. Fousteri, G., Ippolito, E., Ahmed, R. and Hamad, A. R. A. (2017). Beta-cell Specific Autoantibodies: Are they Just an Indicator of Type 1 Diabetes? Curr Diabetes Rev 13(3): 322-329.
  7. Cantarelli, E., Citro, A., Pellegrini, S., Mercalli, A., Melzi, R., Dugnani, E., Jofra, T., Fousteri, G., Mondino, A. and Piemonti, L. (2017). Transplant Site Influences the Immune Response After Islet Transplantation: Bone Marrow Versus Liver. Transplantation 101(5): 1046-1055.
  8. Hamad, A. R., Ahmed, R., Donner, T. and Fousteri, G. (2016). B cell-targeted immunotherapy for type 1 diabetes: What can make it work? Discov Med 21(115): 213-219.
  9. Di Fonte, R., Baronio, M., Plebani, A., Lougaris, V. and Fousteri, G. (2016). Reduced germinal center follicular helper T cells but normal follicular regulatory T cells in the tonsils of a patient with a mutation in the PI3KR1 gene. Clin Immunol 164: 43-44.
  10. Fousteri, G., Jofra, T., Di Fonte, R., Kuka, M., Iannacone, M. and Battaglia, M. (2015). PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Clin Immunol 156(2): 98-108.
  11. Fousteri, G., Jofra, T., Di Fonte, R., Gagliani, N., Morsiani, C., Stabilini, A. and Battaglia, M. (2015). Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice. Diabetologia 58(6): 1319-1328.
  12. Fousteri, G., Jofra, T., Di Fonte, R. and Battaglia, M. (2015). Combination of an Antigen-Specific Therapy and an Immunomodulatory Treatment to Simultaneous Block Recurrent Autoimmunity and Alloreactivity in Non-Obese Diabetic Mice. PLoS One 10(6): e0127631.
  13. Sarikonda, G., Fousteri, G., Sachithanantham, S., Miller, J. F., Dave, A., Juntti, T., Coppieters, K. T. and von Herrath, M. (2014). BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells. PLoS One 9(11): e112242.
  14. Jones, C. B., Pagni, P. P., Fousteri, G., Sachithanantham, S., Dave, A., Rodriguez-Calvo, T., Miller, J. and von Herrath, M. (2014). Regulatory T cells control diabetes without compromising acute anti-viral defense. Clin Immunol 153(2): 298-307.
  15. Fousteri, G., Jofra, T., Debernardis, I., Stanford, S. M., Laurenzi, A., Bottini, N. and Battaglia, M. (2014). The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization. Clin Exp Immunol 178(1): 178-189.
  16. Passerini, L., Rossi Mel, E., Sartirana, C., Fousteri, G., Bondanza, A., Naldini, L., Roncarolo, M. G. and Bacchetta, R. (2013). CD4(+) T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer. Sci Transl Med 5(215): 215ra174.
  17. Fousteri, G., Liossis, S. N. and Battaglia, M. (2013). Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity. Clin Immunol 149(3): 556-565.
  18. Fousteri, G., Jasinski, J., Dave, A., Nakayama, M., Pagni, P., Lambolez, F., Juntti, T., Sarikonda, G., Cheng, Y., Croft, M., Cheroutre, H., Eisenbarth, G. and von Herrath, M. (2012). Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. Diabetes 61(5): 1169-1179.
  19. Andolfi, G., Fousteri, G., Rossetti, M., Magnani, C. F., Jofra, T., Locafaro, G., Bondanza, A., Gregori, S. and Roncarolo, M. G. (2012). Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells. Mol Ther 20(9): 1778-1790.
  20. Fousteri, G., Dave, A., Morin, B., Omid, S., Croft, M. and von Herrath, M. G. (2011). Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis. J Autoimmun 36(3-4): 210-220.
  21. Fousteri, G., Dave, A., Juedes, A., Juntti, T., Morin, B., Togher, L., Farber, D. L. and von Herrath, M. (2011). Increased memory conversion of naive CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure. PLoS One 6(1): e14502.
  22. Bresson, D., Fousteri, G., Manenkova, Y., Croft, M. and von Herrath, M. (2011). Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun 37(4): 342-351.
  23. Fousteri, G., Dave, A., Juntti, T., Morin, B., McClure, M. and Von Herrath, M. (2010). Minimal effect of CD103 expression on the control of a chronic antiviral immune response. Viral Immunol 23(3): 285-294.
  24. Fousteri, G., Dave, A., Bot, A., Juntti, T., Omid, S. and von Herrath, M. (2010). Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma. Diabetologia 53(9): 1958-1970.
  25. Fousteri, G., Chan, J. R., Zheng, Y., Whiting, C., Dave, A., Bresson, D., Croft, M. and von Herrath, M. (2010). Virtual optimization of nasal insulin therapy predicts immunization frequency to be crucial for diabetes protection. Diabetes 59(12): 3148-3158.
  26. Fousteri, G., Dave, A., Juntti, T. and von Herrath, M. (2009). CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes. J Autoimmun 32(1): 70-77.
  27. Fousteri, M. and Mullenders, L. H. (2008). Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects. Cell Res 18(1): 73-84.
  28. Fousteri, G. and von Herrath, M. (2008). First-trimester human fetal pancreas transplantation for type 1 diabetes treatment: an alternative approach for achieving long-term graft survival? Diabetes 57(3): 525-526.
  29. Fousteri, G., von Herrath, M. and Bresson, D. (2007). Mucosal exposure to antigen: cause or cure of type 1 diabetes? Curr Diab Rep 7(2): 91-98.
  30. Fousteri, G., Hayek, A. and von Herrath, M. (2007). Stopping diabetes in its tracks: autologous non-myeloablative stem cell transplantation. Regen Med 2(5): 845-851.
  31. Fousteri, G., Bresson, D. and von Herrath, M. (2007). Rational development of antigen-specific therapies for type 1 diabetes. Adv Exp Med Biol 601: 313-319.
  32. Chatzidakis, I., Fousteri, G., Tsoukatou, D., Kollias, G. and Mamalaki, C. (2007). An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells. J Immunol 178(11): 6735-6745.
1 Protocol published
Murine Pancreatic Islets Transplantation under the Kidney Capsule
Type 1 diabetes (T1D) is an autoimmune disease caused by the lack of insulin-producing pancreatic beta cells leading to systemic hyperglycemia. Pancreatic islet transplantation is a valid therapeutic approach to restore insulin loss and to promote ...
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