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Coauthors
Feifan Zhang Key Laboratory for the Neurodegenerative Disorders of the Chinese Ministry of Education, Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Capital Medical University, China, China,
1 protocol

Cuilian Du 1 protocol

Claire Xi Zhang
  • Key Laboratory for the Neurodegenerative Disorders of the Chinese Ministry of Education, Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Capital Medical University, China, China,
  • 1 Author merit

Education

Ph.D, Duke University, USA, 1999

Current position

Professor, Beijing Institute for Brain Disorders, Capital Medical University, China

Publications

  1. Wang, Y. L. and Zhang, C. X. (2017). Putting a brake on synaptic vesicle endocytosis. Cell Mol Life Sci 74(16): 2917-2927. 

  2. Du, C., Wang, Y., Zhang, F., Yan, S., Guan, Y., Gong, X., Zhang, T., Cui, X., Wang, X. and Zhang, C. X. (2017). Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia. Glia 65(10): 1656-1667. 

  3. Wang, C., Wang, Y., Hu, M., Chai, Z., Wu, Q., Huang, R., Han, W., Zhang, C. X. and Zhou, Z. (2016). Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep 17(1): 47-63.

  4. Kuo, S. T., Wu, Q. H., Liu, B., Xie, Z. L., Wu, X., Shang, S. J., Zhang, X. Y., Kang, X. J., Liu, L. N., Zhu, F. P., Wang, Y. S., Hu, M. Q., Xu, H. D., Zhou, L., Liu, B., Chai, Z. Y., Zhang, Q. F., Liu, W., Teng, S. S., Wang, C. H., Guo, N., Dou, H. Q., Zuo, P. L., Zheng, L. H., Zhang, C. X., Zhu, D. S., Wang, L., Wang, S. R. and Zhou, Z. (2014). Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese university. J Mol Neurosci 53(3): 487-492. 

  5. Zuo, P. L., Yao, W., Sun, L., Kuo, S. T., Li, Q., Wang, S. R., Dou, H. Q., Xu, H. D., Zhang, C. X., Kang, X. J., Zhou, Z. and Zhang, B. (2013). Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo. Neurochem Int 62(1): 50-57. 

  6. Zhang, B., Zhang, X. Y., Luo, P. F., Huang, W., Zhu, F. P., Liu, T., Du, Y. R., Wu, Q. H., Lu, J., Xiu, Y., Liu, L. N., Huang, H. P., Guo, S., Zheng, H., Zhang, C. X. and Zhou, Z. (2012). Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices. J Physiol 590(4): 753-762. 

  7. Huang, H. P., Zhu, F. P., Chen, X. W., Xu, Z. Q., Zhang, C. X. and Zhou, Z. (2012). Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus. Front Mol Neurosci 5: 29. 

  8. Zhang, B., Sun, L., Yang, Y. M., Huang, H. P., Zhu, F. P., Wang, L., Zhang, X. Y., Guo, S., Zuo, P. L., Zhang, C. X., Ding, J. P., Wang, L. Y. and Zhou, Z. (2011). Action potential bursts enhance transmitter release at a giant central synapse. J Physiol 589(Pt 9): 2213-2227. 

  9. Xiong, W., Liu, T., Wang, Y., Chen, X., Sun, L., Guo, N., Zheng, H., Zheng, L., Ruat, M., Han, W., Zhang, C. X. and Zhou, Z. (2011). An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis. PLoS One 6(10): e24573.

  10. Wang, S. R., Yao, W., Huang, H. P., Zhang, B., Zuo, P. L., Sun, L., Dou, H. Q., Li, Q., Kang, X. J., Xu, H. D., Hu, M. Q., Jin, M., Zhang, L., Mu, Y., Peng, J. Y., Zhang, C. X., Ding, J. P., Li, B. M. and Zhou, Z. (2011). Role of vesicle pools in action potential pattern-dependent dopamine overflow in rat striatum in vivo. J Neurochem 119(2): 342-353. 

  11. Liu, T., Sun, L., Xiong, Y., Shang, S., Guo, N., Teng, S., Wang, Y., Liu, B., Wang, C., Wang, L., Zheng, L., Zhang, C. X., Han, W. and Zhou, Z. (2011). Calcium triggers exocytosis from two types of organelles in a single astrocyte. J Neurosci 31(29): 10593-10601. 

  12. Liu, T., Shang, S. J., Liu, B., Wang, C. H., Wang, Y. S., Xiong, W., Zheng, L. H., Zhang, C. X. and Zhou, Z. (2011). Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons. J Physiol 589(Pt 14): 3507-3515. 

  13. Zheng, H., Fan, J., Xiong, W., Zhang, C., Wang, X. B., Liu, T., Liu, H. J., Sun, L., Wang, Y. S., Zheng, L. H., Wang, B. R., Zhang, C. X. and Zhou, Z. (2009). Action potential modulates Ca2+-dependent and Ca2+-independent secretion in a sensory neuron. Biophys J 96(6): 2449-2456. 

  14. Chen, X.-W., Mu, Y., Huang, H.-P., Guo, N., Zhang, B., Fan, S.-Y., Xiong, J.-X., Wang, S.-R., Xiong, W., Huang, W., Liu, T., Zheng, L.-H., Zhang, C. X., Li, L.-H., Yu, Z.-P., Hu, Z.-A. and Zhou, Z. (2008). Hypocretin-1 Potentiates NMDA Receptor-Mediated Somatodendritic Secretion from Locus Ceruleus Neurons. The Journal of Neuroscience 28(12): 3202-3208. 

  15. Chen, X. W., Huang, W., Yan, J. A., Fan, H. X., Guo, N., Lu, J., Xiu, Y., Gu, J. L., Zhang, C. X., Ruan, H. Z., Hu, Z. A., Yu, Z. P. and Zhou, Z. (2008). Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells. Neurosci Lett 436(2): 181-184. 

  16. Chen, X. W., Feng, Y. Q., Hao, C. J., Guo, X. L., He, X., Zhou, Z. Y., Guo, N., Huang, H. P., Xiong, W., Zheng, H., Zuo, P. L., Zhang, C. X., Li, W. and Zhou, Z. (2008). DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J Cell Biol 181(5): 791-801. 

  17. Zhang, C. X. and Hsieh, T. S. (2007). Preparation of membrane proteins from Drosophila embryos. CSH Protoc 2007: pdb.prot4711. 

  18. Yu, X., Chen, X. W., Zhou, P., Yao, L., Liu, T., Zhang, B., Li, Y., Zheng, H., Zheng, L. H., Zhang, C. X., Bruce, I., Ge, J. B., Wang, S. Q., Hu, Z. A., Yu, H. G. and Zhou, Z. (2007). Calcium influx through If channels in rat ventricular myocytes. Am J Physiol Cell Physiol 292(3): C1147-1155. 

  19. Le Clainche, C., Pauly, B. S., Zhang, C. X., Engqvist-Goldstein, A. E., Cunningham, K. and Drubin, D. G. (2007). A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis. Embo j 26(5): 1199-1210. 

  20. Bradley, S. V., Hyun, T. S., Oravecz-Wilson, K. I., Li, L., Waldorff, E. I., Ermilov, A. N., Goldstein, S. A., Zhang, C. X., Drubin, D. G., Varela, K., Parlow, A., Dlugosz, A. A. and Ross, T. S. (2007). Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. Hum Mol Genet 16(11): 1279-1292. 

  21. Zhang, C. X., Engqvist-Goldstein, A. E., Carreno, S., Owen, D. J., Smythe, E. and Drubin, D. G. (2005). Multiple roles for cyclin G-associated kinase in clathrin-mediated sorting events. Traffic 6(12): 1103-1113. 

  22. Engqvist-Goldstein, A. E., Zhang, C. X., Carreno, S., Barroso, C., Heuser, J. E. and Drubin, D. G. (2004). RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. Mol Biol Cell 15(4): 1666-1679. 

  23. Carreno, S., Engqvist-Goldstein, A. E., Zhang, C. X., McDonald, K. L. and Drubin, D. G. (2004). Actin dynamics coupled to clathrin-coated vesicle formation at the trans-Golgi network. J Cell Biol 165(6): 781-788. 

  24. Zhang, C. X., Rothwell, W. F., Sullivan, W. and Hsieh, T. S. (2000). Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila, is membrane associated and hyperphosphorylated. Mol Biol Cell 11(3): 1011-1022. 

  25. Zhang, C. X., Chen, A. D., Gettel, N. J. and Hsieh, T. S. (2000). Essential functions of DNA topoisomerase I in Drosophila melanogaster. Dev Biol 222(1): 27-40. 

  26. Rothwell, W. F., Zhang, C. X., Zelano, C., Hsieh, T. S. and Sullivan, W. (1999). The Drosophila centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo. J Cell Sci 112 ( Pt 17): 2885-2893. 

  27. Brown, S. D., Zhang, C. X., Chen, A. D. and Hsieh, T. S. (1998). Structure of the Drosophila DNA topoisomerase I gene and expression of messages with different lengths in the 3' untranslated region. Gene 211(2): 195-203. 

  28. Zhang, C. X., Lee, M. P., Chen, A. D., Brown, S. D. and Hsieh, T. (1996). Isolation and characterization of a Drosophila gene essential for early embryonic development and formation of cortical cleavage furrows. The Journal of Cell Biology 134(4): 923-934.


1 Protocol published
Phagocytosis Assay for α-Synuclein Fibril Uptake by Mouse Primary Microglia
Authors:  Cuilian Du, Feifan Zhang and Claire Xi Zhang, date: 09/05/2018, view: 110, Q&A: 0
Microglia are professional phagocytes in the brain and deficiency in their phagocytic activity plays an important role in Parkinson’s disease. This protocol mainly describes the phagocytosis assay for uptake of α-synuclein preformed fibrils, a ...