Sandeep Kumar Upadhyay
  • Research associate, Washington University School of Medicine, St Louis
Research focus
  • Microbiology
  • Innate immunity, Autophagy, Microbial pathogenesis and host defence, Mycobacterium tuberculosis, Phagosome biology


Ph.D, National Institute of Immunology, New Delhi, India, 2014

Lab information

Jen Philips Lab


Publications in Last 5 year :

1) Why macrophages cannot LAP up TB.
Köster S*, Upadhyay S*, Philips JA.
Autophagy. 2018 Feb 21:1-3.

2) Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.
Köster S*, Upadhyay S*, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby SJ, Mittal E, Park HS, Jones V, Hsu FF, Jackson M, Sassetti CM, Philips JA.
Proc Natl Acad Sci U S A. 2017 Oct 10

3) Protein kinase G confers survival advantage to Mycobacterium tuberculosis during latency-like conditions.
Khan MZ*, Bhaskar A*, Upadhyay S*, Kumari P, Rajmani RS, Jain P, Singh A, Kumar D, Bhavesh NS, Nandicoori VK.
J Biol Chem. 2017 Sep 29;292(39):16093-16108

4) Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection.
Sharma G, Sowpati DT, Singh P, Khan MZ, Ganji R, Upadhyay S, Banerjee S, Nandicoori VK, Khosla S.
Sci Rep. 2016 Apr 26;6:25006.

5) Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen.
Soni V, Upadhayay S, Suryadevara P, Samla G, Singh A, Yogeeswari P, Sriram D, Nandicoori VK.
PLoS Pathog. 2015 Oct 21;11(10):e1005235.

6) The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding.
Sharma G, Upadhyay S, Srilalitha M, Nandicoori VK, Khosla S.
Nucleic Acids Res. 2015 Apr 30;43(8):3922-37.

7) Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.
Nagarajan SN, Upadhyay S, Chawla Y, Khan S, Naz S, Subramanian J, Gandotra S, Nandicoori VK.
J Biol Chem. 2015 Apr 10;290(15):9626-45.

8) Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host.
Chawla Y, Upadhyay S, Khan S, Nagarajan SN, Forti F, Nandicoori VK.
J Biol Chem. 2014 May 16;289(20):13858-75.

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