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Coreviewers
Saumik Basu Washington State University
2 protocols

Reviewer
Manoj B. Menon
  • Post-Doc, Hannover Medical School
Research focus
  • Biochemistry
  • MAPK Signaling
    Septins
    Cytoskeleton
    Cell death

Education

PhD, Hannover Medical School, 2010

Publications

https://orcid.org/0000-0001-5859-0347

Selected publications:

1. Dhamija S & Menon MB. 2018. Non-coding transcript variants of protein-coding genes - what are they good for? RNA Biol. 15(8): 1025-1031.

2. Abbey M, Gaestel M & Menon MB. 2018. Septins – active GTPases or just GTP-binding proteins? Cytoskeleton. DOI:10.1002/cm.21451

3. Menon MB & Gaestel M. 2018. MK2-TNF Signaling comes full-circle. Trends Biochem Sci. doi:10.1016/j. tibs.2017.12.002 (uncorrected proof published online on 21.12.2017).

4. Menon MB & Gaestel M. 2017. Editorial: Emerging Functions of Septins. Front Cell Dev Biol. 5:73. doi: 10.3389/fcell.2017.00073.

5. Menon MB, Gropengießer J et al. p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signaling in inflammation and infection. Nat Cell Biol. 19, 1248–1259.

6. Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M and Menon MB. 2016. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Scientific Reports.6:20007.

7. Menon MB, Dhamija S, Kotlyarov A and Gaestel M. 2015. The problem of pyridinyl imidazole class inhibitors of p38 MAPK in autophagy research. Autophagy. 11(8): 1425-27.

8. Ugur M, Schulz M, Menon MB, Krueger A & Pabst O. 2014. Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure. Nat Commun. 5:4821.

9. Menon MB & Gaestel M. 2015. Sep(t)arate or not: how some cells take septin-independent routes through cytokinesis. J Cell Science. 128(10):1877-86. (Commentary).

10. Menon MB, Sawada A, Chaturvedi A. et al. 2014. Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS Genet. 10(8):e1004558.

11. Menon MB, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A & Gaestel M. 2013. Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production. Biochem J. 456(2):163-72.

12. Menon MB, Kotlyarov A & Gaestel M. 2011. SB202190-induced cell type-specific vacuole formation & defective autophagy do not depend on p38 MAP kinase inhibition. PLoS One. 6: e23054.

13. Ronkina N, Menon MB et al. 2011. Stress induced gene expression: A direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic Acids Res. 39: 2503-18.

14. Menon MB, Schwermann J, Singh AK, Pabst O, Seidler U, Omary MB, Kotlyarov A, & Gaestel M. 2010. p38 MAP Kinase & MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. J Biol Chem. 285: 33242-51.

15. Ronkina N, Menon MB, Schwermann J, Tiedje C, Hitti E, Kotlyarov A & Gaestel M. 2010. MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Biochem Pharmacol. 80:1915-20.

16. Menon MB, N. Ronkina, Schwermann J, Kotlyarov A & Gaestel M. 2009. Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration. Cell Motil Cytoskeleton. 66:1041-7.
1 Protocol reviewed
Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates
Authors:  Olga Sin, Alejandro Mata-Cabana, Renée I. Seinstra and Ellen A. A. Nollen, date: 10/05/2018, view: 125, Q&A: 0
Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein’s native conformation, which ultimately results in its aggregation or ...
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