Jia-Li Cao State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Science, Xiamen University, China, China,
1 protocol

Jin-Wei Zheng National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, China, China,
1 protocol

Quan Yuan
  • State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Science, Xiamen university, China, China,
  • 1 Author merit


Ph.D in Biochemistry and Molecular Biology, Xiamen University, China, 2012

Current position

Associate professor, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, China

Publications (since 2016)

  1. Zhang, J. F., Xiong, H. L., Cao, J. L., Wang, S. J., Guo, X. R., Lin, B. Y., Zhang, Y., Zhao, J. H., Wang, Y. B., Zhang, T. Y., Yuan, Q., Zhang, J. and Xia, N. S. (2018). A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway. Theranostics 8(2): 549-562.
  2. Li, J., Mao, R. C., Li, X. L., Zheng, J. W., Qi, X., Yuan, Q., Zhang, J., Zhang, J. M. and Xia, N. S. (2018). A novel noninvasive index for the prediction of moderate to severe fibrosis in chronic hepatitis B patients. Dig Liver Dis 50(5): 482-489.
  3. Kang, C., Xia, L., Chen, Y., Zhang, T., Wang, Y., Zhou, B., You, M., Yuan, Q., Tzeng, C. M., An, Z., Luo, W. and Xia, N. (2018). A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys. Protein Cell 9(1): 130-134.
  4. Shen, C., Chen, J., Li, R., Zhang, M., Wang, G., Stegalkina, S., Zhang, L., Chen, J., Cao, J., Bi, X., Anderson, S. F., Alefantis, T., Zhang, M., Cai, X., Yang, K., Zheng, Q., Fang, M., Yu, H., Luo, W., Zheng, Z., Yuan, Q., Zhang, J., Wai-Kuo Shih, J., Kleanthous, H., Chen, H., Chen, Y. and Xia, N. (2017). A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses. Sci Transl Med 9(412).
  5. Wang, J., Chen, R., Zhang, R., Ding, S., Zhang, T., Yuan, Q., Guan, G., Chen, X., Zhang, T., Zhuang, H., Nunes, F., Block, T., Liu, S., Duan, Z., Xia, N., Xu, Z. and Lu, F. (2017). The gRNA-miRNA-gRNA Ternary Cassette Combining CRISPR/Cas9 with RNAi Approach Strongly Inhibits Hepatitis B Virus Replication. Theranostics 7(12): 3090-3105.
  6. Li, X., Zhao, J., Yuan, Q. and Xia, N. (2017). Detection of HBV Covalently Closed Circular DNA. Viruses 9(6).
  7. Gao, Y., Zhang, T. Y., Yuan, Q. and Xia, N. S. (2017). Antibody-mediated immunotherapy against chronic hepatitis B virus infection. Hum Vaccin Immunother 13(8): 1768-1773.
  8. Xu, J. H., Song, L. W., Li, N., Wang, S., Zeng, Z., Si, C. W., Li, J., Mao, Q., Zhang, D. Z., Tang, H., Sheng, J. F., Chen, X. Y., Ning, Q., Shi, G. F., Xie, Q., Yuan, Q., Yu, Y. Y. and Xia, N. S. (2017). Baseline hepatitis B core antibody predicts treatment response in chronic hepatitis B patients receiving long-term entecavir. J Viral Hepat 24(2): 148-154.
  9. Li, J., Zhang, T. Y., Song, L. W., Qi, X., Yu, X. P., Li, F. H., Zhou, P., Qin, Y. L., Yang, L., Zhao, J. H., Mao, R. C., Zhang, Y. M., Wang, J. Y., Yang, F. F., Zhu, H. X., Yang, S. S., Huang, Y. X., Yuan, Q., Zhang, J., Zhang, J. M. and Xia, N. S. (2018). Role of quantitative hepatitis B core antibody levels in predicting significant liver inflammation in chronic hepatitis B patients with normal or near-normal alanine aminotransferase levels. Hepatol Res 48(3): E133-E145.
  10. Zhao, J. H., Zhang, Y. L., Zhang, T. Y., Yuan, L. Z., Cheng, T., Chen, P. J., Yuan, Q. and Xia, N. S. (2017). A novel toolbox for the in vitro assay of hepatitis D virus infection. Sci Rep 7: 40199.
  11. Oliveri, F., Surace, L., Cavallone, D., Colombatto, P., Ricco, G., Salvati, N., Coco, B., Romagnoli, V., Gattai, R., Salvati, A., Moriconi, F., Yuan, Q., Bonino, F. and Brunetto, M. R. (2017). Long-term outcome of inactive and active, low viraemic HBeAg-negative-hepatitis B virus infection: Benign course towards HBsAg clearance. Liver Int 37(11): 1622-1631.
  12. Lin, C., Li, H., Hao, M., Xiong, D., Luo, Y., Huang, C., Yuan, Q., Zhang, J. and Xia, N. (2016). Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep 6: 34531.
  13. Fan, F., He, Z., Kong, L. L., Chen, Q., Yuan, Q., Zhang, S., Ye, J., Liu, H., Sun, X., Geng, J., Yuan, L., Hong, L., Xiao, C., Zhang, W., Sun, X., Li, Y., Wang, P., Huang, L., Wu, X., Ji, Z., Wu, Q., Xia, N. S., Gray, N. S., Chen, L., Yun, C. H., Deng, X. and Zhou, D. (2016). Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med 8(352): 352ra108.
  14. Wu, Y., Zhang, T. Y., Fang, L. L., Chen, Z. X., Song, L. W., Cao, J. L., Yang, L., Yuan, Q. and Xia, N. S. (2016). Sleeping Beauty transposon-based system for rapid generation of HBV-replicating stable cell lines. J Virol Methods 234: 96-100.
  15. Wang, J., Shen, T., Huang, X., Kumar, G. R., Chen, X., Zeng, Z., Zhang, R., Chen, R., Li, T., Zhang, T., Yuan, Q., Li, P. C., Huang, Q., Colonno, R., Jia, J., Hou, J., McCrae, M. A., Gao, Z., Ren, H., Xia, N., Zhuang, H. and Lu, F. (2016). Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. J Hepatol 65(4): 700-710.
  16. Chen, C., Jia, H., Zhang, F., Qin, Y., Zong, L., Yuan, Q., Wang, Y., Xia, N., Li, J., Wen, Y. and Tong, S. (2016). Functional characterization of hepatitis B virus core promoter mutants revealed transcriptional interference among co-terminal viral mRNAs. J Gen Virol 97(10): 2668-2676.
  17. Yuan, L., Wang, T., Zhang, Y., Liu, X., Zhang, T., Li, X., Liu, P., Wu, K., Shih, J. W., Yuan, Q., Cheng, T. and Xia, N. (2016). An HBV-tolerant immunocompetent model that effectively simulates chronic hepatitis B virus infection in mice. Exp Anim 65(4): 373-382.
  18. Qiu, X., Song, L., Yang, S., Guo, M., Yuan, Q., Ge, S., Min, X. and Xia, N. (2016). A fast and low-cost genotyping method for hepatitis B virus based on pattern recognition in point-of-care settings. Sci Rep 6: 28274.
  19. Luo, Y., Xiong, D., Li, H. H., Qiu, S. P., Lin, C. L., Chen, Q., Huang, C. H., Yuan, Q., Zhang, J. and Xia, N. S. (2016). Development of an HSV-1 neutralization test with a glycoprotein D specific antibody for measurement of neutralizing antibody titer in human sera. Virol J 13: 44.
  20. Zhang, T. Y., Yuan, Q., Zhao, J. H., Zhang, Y. L., Yuan, L. Z., Lan, Y., Lo, Y. C., Sun, C. P., Wu, C. R., Zhang, J. F., Zhang, Y., Cao, J. L., Guo, X. R., Liu, X., Mo, X. B., Luo, W. X., Cheng, T., Chen, Y. X., Tao, M. H., Shih, J. W., Zhao, Q. J., Zhang, J., Chen, P. J., Yuan, Y. A. and Xia, N. S. (2016). Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen. Gut 65(4): 658-671.
1 Protocol published
Sleeping Beauty Transposon-based System for Rapid Generation of HBV-replicating Stable Cell Lines
Authors:  Jin-Wei Zheng, Jia-Li Cao and Quan Yuan , date: 07/05/2018, view: 322, Q&A: 0
The stable HBV-transfected cell lines, which based on stable integration of replication-competent HBV genome into hepatic cells, are widely used in basic research and antiviral drug evaluation against HBV. However, previous reported strategies to ...