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Reviewer
Antonino Bruno
  • Research scientist, IRCCS MultiMedica
Research focus
  • Cancer biology
  • Tumor immunology, tumour microenvironment, angiogenesis, inflammation

Education

PhD, University of Insubria, 2011

Lab information

Laboratory of Vascular Biology and Angiogenesis
http://www.multimedica.it

Publications

1) Annalisa Bosi, Silvia Zanellato, Barbara Bassani, Andriana Albini, Alessandra Musco, Maria Cattoni, Matteo Desio, Elisa Nardecchia, Davide Giuseppe D'Urso, Andrea Imperatori, Lorenzo Dominioni, Douglas Noonan, Lorenzo Mortara, and Antonino Bruno. Natural Killer cells from malignant pleural effusion are endowed with a decidual-like pro-angiogenic polarization, in press, Journal of Imm. Res (IF:3.276)

2) Bassani B., Bruno A., Macrì N., Corradino P., Noonan D.M., Albini A. (2017) The Pharmacologist’s Point of View: Mechanisms of Cardiotoxicity. In: Lestuzzi C., Oliva S., Ferraù F. (eds) Manual of Cardio-oncology. Springer, Cham, https://doi.org/10.1007/978-3-319-40236-9_7

3) Albini A, Bassani B1, Baci D, Dallaglio K, Gallazzi M, Corradino P, Bruno A*, Noonan DM*. Nutraceuticals and "repurposed" drugs of phytochemical origin in prevention and interception of chronic degenerative disease and cancer, Curr Med Chem. 2017 Sep 20. [Epub ahead of print]. IF: 3.249

4) E. Nuti, B. Bassani, C. Camodeca, L. Rosalia, A. Cantelmo, C. Gallo, D. Baci, A. Bruno, E. Orlandini, S. Nencetti, D. Noonan, A. Albini, A. Rossello, Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues, European Journal of Medicinal Chemistry (2017), doi: 10.1016/j.ejmech.2017.07.024. IF: 4.519

5) Parisi L, Bassani B, Tremolati M, Gini E, Farronato G, Bruno A. Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases. J Immunol Res. 2017;2017:4218254. doi: 10.1155/2017/4218254. Epub 2017 Mar 27. IF: 3.276

6) Simone Cristoni, Guglielmo Dusi, Paolo Brambilla, Adriana Albini, Matteo Conti, Maura Brambilla, Antonino Bruno, Francesca Digaudio, Luca Ferlin, Valeria Tazzari, Silvia Mengozzi, Simone Barera, Carlos Salier, Luigi Rossi Bernardi, and Douglas M. Noonan, SANIST: optimization of a technology for compound identification based on the European Union directive with applications in forensic, pharmaceutical and food analyses, J Mass Spectrom. 2016 Oct 24. doi: 10.1002/jms.3895 (IF: 1.998)

7) Barbara Bassani, Teresa Rossi, Daniela De Stefano, Daniele Pizzichini, Paola Corradino, Nicoletta Macrì, Douglas M. Noonan, Adriana Albini*, Antonino Bruno*, Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells, Journal of Functional Foods 7 (2016) 236–248, http://dx.doi.org/10.1016/j.jff.2016.09.009. (IF:3.574).

8) Cristina Gallo, Katiuscia Dallaglio, Barbara Bassani, Teresa Rossi , Armando Rossello , Douglas Noonan , Gabriele D'Uva , Antonino Bruno, Adriana Albini, Hop derived flavonoid Xanthohumol inhibits endothelial cell functions via AMPK activation, Oncotarget 2016, (IF: 5.168)

9) Elisa Principi*, Rossana Girardello*, Antonino Bruno*, Isabella Manni, Elisabetta Gini, Arianna Pagani, Annalisa Grimaldi, Federico Ivaldi, Terenzio Congiu, Daniela De Stefano, Giulia Piaggio, Magda de Eguileor, Douglas M. Noonan and Adriana Albini, Int. journal of Nanomedicine, 2016 Sep 1;11:4299-316 (IF: 4.3).

10) Barbara Bassani, Desirèe Bartolini, Arianna Pagani, Elisa Principi, Massimo Zollo, Douglas Noonan, Adriana Albini, Antonino Bruno, Fenretinide (4-HPR) targets caspase-9, ERK 1/2 and the Wnt3a/-catenin pathway in medulloblastoma cells and medulloblastoma cell spheroids, PlosOne, 2016 Jul 1;11(7):e0154111, (IF 2.806).

11) Adriana Albini, Francesco Bertolini, Barbara Bassani, Antonino Bruno, Cristina Gallo, Stefano Caraffi, Sally Maramotti, Douglas M. Noonan, Biomarkers of cancer angioprevention for clinical studies, eCancer. 2015 Nov 24;9:600.

12) Adriana Albini*, Antonino Bruno*, Cristina Gallo, Giorgio Pajardi, Douglas M. Noonan, Katiuscia Dallaglio, Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity, Connettive Tissue Research, 2015 Oct;56(5):414-2, (IF 1.607).

13) Adriana Albini, Daniela Briga, Matteo Conti, Antonino Bruno, Daniela Farioli, Sara Canali, Ilaria Sogno, Gioacchino D'Ambrosio, Paolo Consonni, Douglas M. Noonan, SANIST: a rapid mass spectrometric SACI/ESI data acquisition and elaboration platform for verifying potential candidate biomarkers, Rapid Communications in Mass Spectrometry 2015 Oct 15;29(19):1703-1, (IF 1.998).

14) Adriana Albini, Arianna Pagani, Laura Pulze, Antonino Bruno, Elisa Principi, Terenzio Congiu, Elisabetta Gini, Annalisa Grimaldi, Barbara Bassani, Silvio De Flora, Magda de Eguileor, Douglas M Noonan, Environmental impact of multi-wall carbon nanotubes in a rodent model of exposure: systemic distribution, macrophage accumulation and amyloid deposition, International Journal of Nanomedicine 2015 Sep 29;10:6133-45 (IF 4.3).

15) Nuti Elisa, Cantelmo, Anna Rita Gallo Cristina, Bruno Antonino, Bassani Barbara, Camodeca Caterina, Tuccinardi Tiziano, Vera Laura, Orlandini Elisabetta, Nencetti Susanna, Stura Enrico, Martinelli Adriano, Dive Vincent, Albini Adriana, Rossello Armando, N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in vivo Antiangiogenic Activity, J Med Chem. 2015 Aug 11. [Epub ahead of print] (IF 6.259).

16) Lorenzo Mortara, Silvia Zanellato, Barbara Bassani, Andrea Imperatori, Nicola Rotolo, Lorenzo Dominioni, Adriana Albini, Douglas M Noonan and Antonino Bruno, Polarization of Tumor Infiltrating Leukocytes from Innate Immunity and their role in the Pro-angiogenic Phenotype in NSCLC, Journal of Clinical & Cellular Immunology, doi: 10.4172/2155-9899.1000312.

17) Teresa Rossi, Barbara Bassani, Cristina Gallo, Sally Maramotti, Douglas M Noonan, Adriana Albini and Antonino Bruno, Effect of a Purified Extract of Olive Mill Waste water on Endothelial Cell Proliferation, Apoptosis, Migration and Capillary-Like Structure in vitro and in vivo, Journal of Bioanalysis & Biomedicine, doi: 10.4172/1948-593X.S12-006.

18) Chiara Focaccetti*, Antonino Bruno*, Elena Magnani, Desirée Bartolini, Elisa Principi, Katiuscia Dallaglio, Eraldo O. Bucci, Giovanna Finzi, Fausto Sessa, Douglas M. Noonan, Adriana Albini, Effects of 5-Fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes. PLoS One. 2015 Feb 11;10(2):e0115686, (IF 2.806).

19) Rossi T, Gallo C, Bassani B, Canali S, Albini A, Bruno A. Drink your prevention: beverages with cancer preventive phytochemicals. Pol Arch Med Wewn. 2014 Dec 23;124(12):713-22. Epub 2014 Dec 6. (IF: 2.052).

20) Fania C, Sogno I, Vasso M, Torretta E, Leone R, Bruno A, Consonni P, Albini A, Gelfi C, A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification, Clin Chim Acta. 2014 Oct 11. pii: S0009-8981(14)00434-3, (IF: 2.873).

21) Antonino Bruno*, Guido Ferlazzo*, Adriana Albini, Douglas M Noonan, A think tank on TINK/TANKs: Tumor Infiltrating Natural Killer cells and their role in angiogenesis and tumor progression, J Natl Cancer Inst. 2014 Sep 1;106(8). pii: dju200. Print 2014 Aug. (IF: 12.589).

22) Bruno A, Pagani A, Pulze L, Albini A, Dallaglio K, Noonan DM, Mortara L. Orchestration of angiogenesis by immune cells. Front Oncol. 2014 Jul 2;4:131.doi: 10.3389/fonc.2014.00131. PubMed PMID: 25072019.

23) Kronski E, Fiori ME, Barbieri O, Astigiano S, Mirisola V, Killian PH, Bruno A, Pagani A, Rovera F, Pfeffer U, Sommerhoff CP, Noonan DM, Nerlich AG, Fontana L, Bachmeier BE. miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2. Mol Oncol. 2014 May;8(3):581-95.doi:10.1016/j.molonc.2014.01.005. PubMed PMID: 24484937. (IF 5.314).

24) Dallaglio K, Bruno A*, Cantelmo AR*, Esposito AI, Ruggiero L, Orecchioni S, Calleri A, Bertolini F, Pfeffer U, Noonan DM, Albini A. Paradoxic effects of metformin on endothelial cells and angiogenesis. Carcinogenesis. 2014 May;35(5):1055-66. doi: 10.1093/carcin/bgu001. PMID: 24419232. (IF: 5.106).

25) Bruno A, Pagani A, Magnani E, Rossi T, Noonan DM, Cantelmo AR, Albini A. Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention. Cancer Treat Res. 2014;159:401-26. doi: 10.1007/978-3-642-38007-5_23. PubMed PMID: 24114493.

26) Bruno A, Focaccetti C, Pagani A, Imperatori AS, Spagnoletti M, Rotolo N, Cantelmo AR, Franzi F, Capella C, Ferlazzo G, Mortara L, Albini A, Noonan DM. The proangiogenic phenotype of natural killer cells in patients with non-small cell lung cancer. Neoplasia. 2013 Feb;15(2):133-42. PubMed PMID: 23441128 (IF: 5.006)

27) Douglas M. Noonan, Agostina Ventura, Antonino Bruno, Arianna Pagani and Adriana Albini, The Angiogenic Switch: Role of Immune Cells, Immunologic Signatures of Rejection, 2011 (book chapter).