Anca Savulescu University of Cape Town
20 protocols

Cristina Suárez Heidelberg University
2 protocols

George Carnell University of Cambridge
3 protocols

Laura Campisi Icahn School of Medicine at Mount Sinai
5 protocols

Reviewer
Vikas Duhan
  • International Fellow, Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute
Research focus
  • Immunology
  • Viral infection, lymphocytic choriomeningitis virus, vesicular stomatitis virus, viral replication, immune activation, CD8 T cell, B cell, T cell exhaustion, immunopathology, cancer immunology, cancer immunotherapy

Education

PhD, University of Duisburg-Essen, 2017

Lab information

Mark Smyth Laboratory- Immunology in Cancer and Infection
https://www.qimrberghofer.edu.au/lab/immunology-in-cancer-and-infection/

Publications

First/Last author scientific publications

1. Hamdan TA, Bhat H, Cham LB, Adomati T, Lang J, Li F, Murtaza A, Hardt C, Lang PA, Duhan V*, Lang KS*. Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection. Pathogens. 2020 Feb 4;9(2).
https://www.mdpi.com/2076-0817/9/2/96

2. Duhan V, Hamdan TA, Xu HC, Shinde P, Bhat H, Li F, Al-Matary Y, Häussinger D, Bezgovsek J, Friedrich SK, Hardt C, Lang PA, Lang KS. NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection. PLoS Pathog. 2019 Jun 20;15(6):e1007797.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007797

3. Khairnar V*, Duhan V*, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Astrid M. Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, and Lang KS. CEACAM1 promotes CD8+ T-cell responses and improves control of a chronic viral infection. Nat Commun. 2018 Jul 2;9(1):2561.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028648/

4. Shaabani N*, Duhan V*, Khairnar V*, Gassa A, Ferrer-Tur R, Häussinger D, Recher M, Zelinskyy G, Liu J, Dittmer U, Trilling M, Scheu S, Hardt C, Lang PA, Honke N, Lang KS. CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection. Cell Death Dis. 2016 Nov 3;7(11):e2446.
https://www.nature.com/articles/cddis2016350

5. Duhan V, Khairnar V, Friedrich SK, Zhou F, Gassa A, Honke N, Shaabani N, Gailus N, Botezatu L, Khandanpour C, Dittmer U, Häussinger D, Recher M, Hardt C, Lang PA, Lang KS. Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8+ T-cell priming and viral control. Sci Rep. 2016 Jan 25;6:19191.
https://www.nature.com/articles/srep19191

6. Shaabani N*, Khairnar V*, Duhan V*, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, Lang KS. Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation. J Autoimmun. 2016 Feb;67:82-9.
https://www.sciencedirect.com/science/article/pii/S0896841115300494?via%3Dihub

7. Khairnar V*, Duhan V*, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun. 2015 Feb 18;6:6217.
https://www.nature.com/articles/ncomms7217

8. Duhan V, Joshi N, Nagarajan P, Upadhyay P. Protocol for Long Duration Whole Body Hyperthermia in Mice. J Vis Exp. 2012 Aug 25;(66):e3801.
https://www.jove.com/video/3801/protocol-for-long-duration-whole-body-hyperthermia-in-mice

*Authors contributed equally to work


Co-author scientific publications

9. Friedrich SK, Schmitz R, Bergerhausen M, Lang J, Cham LB, Duhan V, Häussinger D, Hardt C, Addo M, Prinz M, Asano K, Lang PA, Lang KS. Usp18 Expression in CD169+ Macrophages is Important for Strong Immune Response after Vaccination with VSV-EBOV. Vaccines (Basel). 2020 Mar 23;8(1). pii: E142.
https://www.mdpi.com/2076-393X/8/1/142

10. Adomati T, Cham LB, Hamdan TA, Bhat H, Duhan V, Li F, Ali M, Lang E, Huang A, Naser E, Khairnar V, Friedrich SK, Lang J, Friebus-Kardash J, Bergerhausen M, Schiller M, Machlah YM, Lang F, Häussinger D, Ferencik S, Hardt C, Lang PA, Lang KS. Dead Cells Induce Innate Anergy via Mertk after Acute Viral Infection. Cell Rep. 2020 Mar 17;30(11):3671-3681.e5.
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30275-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124720302758%3Fshowall%3Dtrue

11. Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun. 2020 Mar 12;11(1):1338.
https://www.nature.com/articles/s41467-020-15072-8

12. Cham LB, Friedrich SK, Adomati T, Bhat H, Schiller M, Bergerhausen M, Hamdan T, Li F, Machlah YM, Ali M, Duhan V, Lang KS, Friebus-Kardash J, Lang J. Tamoxifen Protects from Vesicular Stomatitis Virus Infection. Pharmaceuticals 2019, 12(4), 142.
https://www.mdpi.com/1424-8247/12/4/142

13. Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwälder M, Lang KS, Ruland J. The uric acid crystal receptor Clec12A potentiates type I interferon responses. Proc Natl Acad Sci U S A. 2019 Aug 26.
https://www.pnas.org/content/early/2019/08/23/1821351116

14. Wagner JM, Reinkemeier F, Wallner C, Dadras M, Huber J, Schmidt SV, Drysch M, Dittfeld S, Jaurich H, Becerikli M, Becker K, Rauch N, Duhan V, Lehnhardt M, Behr B. Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response. Stem Cells Transl Med. 2019 Jun 10.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0266

15. Solmaz G, Puttur F, Francozo M, Lindenberg M, Guderian M, Swallow M, Duhan V, Khairnar V, Kalinke U, Ludewig B, Clausen BE, Wagner H, Lang KS, Sparwasser TD. TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion. Front Immunol. 2019 Mar 15;10:466. https://www.frontiersin.org/articles/10.3389/fimmu.2019.00466/full

16. Wagner JM, Jaurich H, Wallner C, Abraham S, Becerikli M, Dadras M, Harati K, Duhan V, Khairnar V, Lehnhardt M, Behr B. Diminished bone regeneration after debridement of posttraumatic osteomyelitis is accompanied by altered cytokine levels, elevated B cell activity, and increased osteoclast activity. J Orthop Res. 2017 Mar 6.
https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.23555

17. Drommelschmidt K, Serdar M, Bendix I, Herz J, Bertling F, Prager S, Keller M, Ludwig AK, Duhan V, Radtke S, de Miroschedji K, Horn PA, van de Looij Y, Giebel B, Felderhoff-Müser U. Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury. Brain Behav Immun. 2017 Feb;60:220-232.
https://www.sciencedirect.com/science/article/pii/S088915911630513X?via%3Dihub


18. Gassa A, Kalkavan H, Jian F, Duhan V, Khairnar V, Shaabani N, Honke N, Carpinteiro A, Botezatu L, Crivello P, Dolff S, Ferencik S, Häussinger D, Khandanpour C, Fleischhauer K, Witzke O, Wahlers T, Hardt C, Lang PA, Lang KS. High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model. Cell Physiol Biochem. 2016;38(4):1343-53.
https://www.karger.com/Article/FullText/443078

19. Gassa A, Jian F, Kalkavan H, Duhan V, Honke N, Shaabani N, Friedrich SK, Dolff S, Wahlers T, Kribben A, Hardt C, Lang PA, Witzke O, Lang KS. IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cell Physiol Biochem. 2016;38(3):1171-81.
https://www.karger.com/Article/FullText/443067


20. Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. Cell Physiol Biochem. 2015;36(6):2379-92.
https://www.karger.com/Article/FullText/430200

21. Shaabani N, Honke N, Dolff S, Görg B, Khairnar V, Merches K, Duhan V, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O, Lang PA, Lang KS. IFN-γ licenses CD11b+ cells to induce progression of systemic lupus erythematosus. J Autoimmun. 2015 Aug;62:11-21.
https://www.sciencedirect.com/science/article/pii/S0896841115000785?via%3Dihub


22. Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA. Deficiency of the B Cell-Activating Factor Receptor Results in Limited CD169+ Macrophage Function during Viral Infection. J Virol. 2015 May;89(9):4748-59.
https://jvi.asm.org/content/89/9/4748.long

23. Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015 Jan;22(1):164-73.
https://www.nature.com/articles/cdd2014138


24. Joshi N, Duhan V, Lingwal N, Bhaskar S, Upadhyay P. Adjuvant properties of thermal component of hyperthermia enhanced transdermal immunization: effect on dendritic cells. PLoS One. 2012;7(2):e32067.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032067


Reviews

25. Bezgovsek J, Gulbins E, Friedrich SK, Lang KS, Duhan V. Sphingolipids in early viral replication and innate immune activation. Biol Chem. 2018 Sep 25;399(10):1115-1123.
https://www.degruyter.com/view/j/bchm.2018.399.issue-10/hsz-2018-0181/hsz-2018-0181.xml

26. Friedrich SK, Lang PA, Friebus-Kardash J, Duhan V, Bezgovsek J, Lang KS. Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease. Clin Exp Immunol. 2019 Jan;195(1):64-73. https://onlinelibrary.wiley.com/doi/full/10.1111/cei.13241
3 Protocols reviewed
Identification of Buffer Conditions for Optimal Thermostability and Solubility of Herpesviral Protein UL37 Using the Thermofluor Assay
Authors:  Andrea L. Koenigsberg, Jared D. Pitts and Ekaterina E. Heldwein, date: 06/20/2020, view: 641, Q&A: 0
Structural and biochemical studies of proteins require high amounts of stable, purified proteins. Protein stability often depends on the buffer composition, which includes pH and concentration of salts or other solutes such as glycerol, hence an ...
More >
Methodology for in vitro Assessment of Human T Cell Activation and Blockade
Authors:  Joseph R. Podojil, Igal Ifergan, Ming-Yi Chiang, Joshua J. Meeks and Stephen D. Miller, date: 06/05/2020, view: 962, Q&A: 0
Methods to test both the functionality and mechanism of action for human recombinant proteins and antibodies in vitro have been limited by multiple factors. To test the functionality of a recombinant protein or antibody, the receptor, the ...
More >
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