Hongme Mou
  • Faculty, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, United States, United States,
Research focus
  • Cell biology
  • 1 Author merit

Education

Ph.D., University of New Hampshire, USA, 2002

Current position

Instructor, The Mucosal Immunology & Biology Research Center , Massachusetts General Hospital / Harvard Medical School , USA, 2017-0

Publications (since2012)

  1. Lynch, T. J., Anderson, P. J., Rotti, P. G., Tyler, S. R., Crooke, A. K., Choi, S. H., Montoro, D. T., Silverman, C. L., Shahin, W., Zhao, R., Jensen-Cody, C. W., Adamcakova-Dodd, A., Evans, T. I. A., Xie, W., Zhang, Y., Mou, H., Herring, B. P., Thorne, P. S., Rajagopal, J., Yeaman, C., Parekh, K. R. and Engelhardt, J. F. (2018). Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell 22(5): 653-667 e655.
  2. Mou, H. (2018). Quality before Quantity: Inspecting CFTR. Dev Cell 44(6): 655-656.
  3. Tata, P. R., Chow, R. D., Saladi, S. V., Tata, A., Konkimalla, A., Bara, A., Montoro, D., Hariri, L. P., Shih, A. R., Mino-Kenudson, M., Mou, H., Kimura, S., Ellisen, L. W. and Rajagopal, J. (2018). Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell 44(6): 679-693 e675.
  4. Yonker, L. M., Pazos, M. A., Lanter, B. B., Mou, H., Chu, K. K., Eaton, A. D., Bonventre, J. V., Tearney, G. J., Rajagopal, J. and Hurley, B. P. (2017). Neutrophil-Derived Cytosolic PLA2alpha Contributes to Bacterial-Induced Neutrophil Transepithelial Migration. J Immunol 199(8): 2873-2884.
  5. Yonker, L.M., Mou, H., Chu, K.K., Pazos, M.A., Leung, H., Cui, D., Ryu, J., Hibbler, R.M., Eaton, A.D., Ford, T.N., Falck, J.R., Kinane ,T.B., Tearney, G.J., Rajagopal, J., Hurley, B.P. (2017). Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. Sci Rep. Aug 15;7(1):8182
  6. Saladi, S. V., Ross, K., Karaayvaz, M., Tata, P. R., Mou, H., Rajagopal, J., Ramaswamy, S. and Ellisen, L. W. (2017). ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell 31(1): 35-49.
  7. Mou, H., Vinarsky, V., Tata, P. R., Brazauskas, K., Choi, S. H., Crooke, A. K., Zhang, B., Solomon, G. M., Turner, B., Bihler, H., Harrington, J., Lapey, A., Channick, C., Keyes, C., Freund, A., Artandi, S., Mense, M., Rowe, S., Engelhardt, J. F., Hsu, Y. C. and Rajagopal, J. (2016). Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell 19(2): 217-231.
  8. Mou, H., Brazauskas, K., Rajagopal, J. (2015). Personalized medicine for cystic fibrosis:: Establishing a Human Model System. Pediatric Pulmonology 50:S14-S23
  9. Dowdall, J. R., Sadow, P. M., Hartnick, C., Vinarsky, V., Mou, H., Zhao, R., Song, P. C., Franco, R. A. and Rajagopal, J. (2015). Identification of distinct layers within the stratified squamous epithelium of the adult human true vocal fold. Laryngoscope 125(9): E313-319.
  10. Pardo-Saganta, A., Law, B. M., Tata, P. R., Villoria, J., Saez, B., Mou, H., Zhao, R. and Rajagopal, J. (2015). Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell 16(2): 184-197.
  11. Gilpin, S. E., Ren, X., Okamoto, T., Guyette, J. P., Mou, H., Rajagopal, J., Mathisen, D. J., Vacanti, J. P. and Ott, H. C. (2014). Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. Ann Thorac Surg 98(5): 1721-1729; discussion 1729.
  12. Zhao, R., Fallon, T. R., Saladi, S. V., Pardo-Saganta, A., Villoria, J., Mou, H., Vinarsky, V., Gonzalez-Celeiro, M., Nunna, N., Hariri, L. P., Camargo, F., Ellisen, L. W. and Rajagopal, J. (2014). Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 30(2): 151-165.
  13. Tata, P. R., Mou, H., Pardo-Saganta, A., Zhao, R., Prabhu, M., Law, B. M., Vinarsky, V., Cho, J. L., Breton, S., Sahay, A., Medoff, B. D. and Rajagopal, J. (2013). Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 503(7475): 218-223.
  14. Mou, H., Zhao, R., Sherwood, R., Ahfeldt, T., Lapey, A., Wain, J., Sicilian, L., Izvolsky, K., Musunuru, K., Cowan, C. and Rajagopal, J. (2012). Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell 10(4): 385-397.
  15. Longmire, T. A., Ikonomou, L., Hawkins, F., Christodoulou, C., Cao, Y., Jean, J. C., Kwok, L. W., Mou, H., Rajagopal, J., Shen, S. S., Dowton, A. A., Serra, M., Weiss, D. J., Green, M. D., Snoeck, H. W., Ramirez, M. I. and Kotton, D. N. (2012). Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell 10(4): 398-411.
1 Protocol published
Expansion of Airway Basal Cells and Generation of Polarized Epithelium
Authors:  Hannah Levardon, Lael M. Yonker, Bryan P. Hurley and Hongmei Mou, date: 06/05/2018, view: 1526, Q&A: 1
Airway basal stem cells are the progenitor cells within the airway that exhibit the capacity to self-renew and give rise to multiple types of differentiated airway epithelial cells. This stem cell-derived epithelium displays organized architecture ...
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