Soleil Schutte Anesthesiology, University of Florida, Gainesville, United States, United States,
1 protocol

Alexa Roemmich Developmental and Cell Biology, UC Irvine, United States, United States,
1 protocol

Diane K O'Dowd
  • Faculty, Developmental and Cell Biology, UC Irvine, United States, United States,
Research focus
  • Developmental and Cell Biology
  • Epilepsy, Sodium Channels, Drosophila, human iPSCs, knock-in mouse models
  • 1 Author merit


Ph.D., UC San Diego, 1985

Lab information

Diane O'Dowd Lab


1.Schutte, R. J., Xie, Y., Ng, N. N., Figueroa, P., Pham, A. T. and O'Dowd, D. K. (2018). Astrocyte-enriched feeder layers from cryopreserved cells support differentiation of spontaneously active networks of human iPSC-derived neurons. J Neurosci Methods 294: 91-101.
2.Xie, Y., Schutte, R. J., Ng, N. N., Ess, K. C., Schwartz, P. H. and O'Dowd, D. K. (2018). Reproducible and efficient generation of functionally active neurons from human hiPSCs for preclinical disease modeling. Stem Cell Res 26: 84-94.
3.Dennin, M., Schultz, Z. D., Feig, A., Finkelstein, N., Greenhoot, A. F., Hildreth, M., Leibovich, A. K., Martin, J. D., Moldwin, M. B., O'Dowd, D. K., Posey, L. A., Smith, T. L. and Miller, E. R. (2017). Aligning Practice to Policies: Changing the Culture to Recognize and Reward Teaching at Research Universities. CBE Life Sci Educ 16(4).
4.Schutte, S. S., Schutte, R. J., Barragan, E. V. and O'Dowd, D. K. (2016). Model systems for studying cellular mechanisms of SCN1A-related epilepsy. J Neurophysiol 115(4): 1755-1766.
5.Guven-Ozkan, T., Busto, G. U., Schutte, S. S., Cervantes-Sandoval, I., O'Dowd, D. K. and Davis, R. L. (2016). MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1. Cell Rep 14(7): 1698-1709.
6. Reimer, L., K. Schenke, T. Nguyen, D. K. O’Dowd, T. Domina, and M. Waschauer (2016) Evaluating promising practices in undergraduate STEM lecture courses. The Russell Sage Foundation Journal of the Social Sciences
7.Williams, A.E., N. M. Aguilar-Roca, and D.K. O’Dowd (2016) Lecture capture podcasts: differential student use and performance in a large introductory course. Education Technology Research and Development 64: 1-12.
8. Jiang, S., A.E. Williams, M. Warschauer, W. He, and D.K.O'Dowd (2014) Influence of incentives on performance in a Pre-college Biology MOOC. International Review of Research in Open and Distance Learning(IRRODL) 15.5
9.Brick, D. J., Nethercott, H. E., Montesano, S., Banuelos, M. G., Stover, A. E., Schutte, S. S., O'Dowd, D. K., Hagerman, R. J., Ono, M., Hessl, D. R., Tassone, F. and Schwartz, P. H. (2014). The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery. Stem Cells Transl Med 3(11): 1275-1286.
10.Schutte, R. J., Schutte, S. S., Algara, J., Barragan, E. V., Gilligan, J., Staber, C., Savva, Y. A., Smith, M. A., Reenan, R. and O'Dowd, D. K. (2014). Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current. J Neurophysiol 112(4): 903-912.
11.Narayanareddy, B. R., Vartiainen, S., Hariri, N., O'Dowd, D. K. and Gross, S. P. (2014). A biophysical analysis of mitochondrial movement: differences between transport in neuronal cell bodies versus processes. Traffic 15(7): 762-771.
12.Iniguez, J., Schutte, S. S. and O'Dowd, D. K. (2013). Cav3-type alpha1T calcium channels mediate transient calcium currents that regulate repetitive firing in Drosophila antennal lobe PNs. J Neurophysiol 110(7): 1490-1496.
13.Stover, A. E., Brick, D. J., Nethercott, H. E., Banuelos, M. G., Sun, L., O'Dowd, D. K. and Schwartz, P. H. (2013). Process-based expansion and neural differentiation of human pluripotent stem cells for transplantation and disease modeling. J Neurosci Res 91(10): 1247-1262.
14.Aguilar-Roca, N.M., A. E. Williams, and D.K. O’Dowd (2012) The impact of laptop-free zones on student performance and attitudes in large lectures. Computers & Education 59: 1300-1308.
15.Sun, L., Gilligan, J., Staber, C., Schutte, R. J., Nguyen, V., O'Dowd, D. K. and Reenan, R. (2012). A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J Neurosci 32(41): 14145-14155.
16.Williams, A. E., Aguilar-Roca, N. M., Tsai, M., Wong, M., Beaupre, M. M. and O'Dowd, D. K. (2011). Assessment of learning gains associated with independent exam analysis in introductory biology. CBE Life Sci Educ 10(4): 346-356.
17.Anderson, W. A., Amasino, R. M., Ares, M., Jr., Banerjee, U., Bartel, B., Corces, V. G., Drennan, C. L., Elgin, S. C., Epstein, I. R., Fanning, E., Guillette, L. J., Jr., Handelsman, J., Hatfull, G. F., Hoy, R. R., Kelley, D., Leinwand, L. A., Losick, R., Lu, Y., Lynn, D. G., Neuhauser, C., O'Dowd, D. K., Olivera, T., Pevzner, P., Richards-Kortum, R. R., Rine, J., Sah, R. L., Strobel, S. A., Walker, G. C., Walt, D. R., Warner, I. M., Wessler, S., Willard, H. F. and Zare, R. N. (2011). Competencies: a cure for pre-med curriculum. Science 334(6057): 760-761.
17.Anderson, W. A., Banerjee, U., Drennan, C. L., Elgin, S. C., Epstein, I. R., Handelsman, J., Hatfull, G. F., Losick, R., O'Dowd, D. K., Olivera, B. M., Strobel, S. A., Walker, G. C. and Warner, I. M. (2011). Science education. Changing the culture of science education at research universities. Science 331(6014): 152-153.
18.Ren, P., Zhang, H., Qiu, F., Liu, Y. Q., Gu, H., O'Dowd, D. K., Zhou, Q. Y. and Hu, W. P. (2011). Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons. PLoS One 6(6): e20263.
19.Moravec, M., Williams, A., Aguilar-Roca, N. and O'Dowd, D. K. (2010). Learn before lecture: A strategy that improves learning outcomes in a large introductory biology class. CBE Life Sci Educ 9(4): 473-481.

1 Protocol published
Ex vivo Whole-cell Recordings in Adult Drosophila Brain
Authors:  Alexa J. Roemmich, Soleil S. Schutte and Diane K. O’Dowd, date: 07/20/2018, view: 262, Q&A: 0
Cost-effective and efficient, the fruit fly (Drosophila melanogaster) has been used to make many key discoveries in the field of neuroscience and to model a number of neurological disorders. Great strides in understanding have been made ...