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Coauthors
Joerg Heeren 1 protocol

Clara John 1 protocol

Anna Worthmann
  • Department for Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Germany, Germany,
  • 1 Author merit

Education

Ph.D, University of Hamburg, Germany

Current position

Postdoctoral Researcher, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Germany

Publications

  1. Chai, C., Rivkin, M., Berkovits, L., Simerzin, A., Zorde-Khvalevsky, E., Rosenberg, N., Klein, S., Yaish, D., Durst, R., Shpitzen, S., Udi, S., Tam, J., Heeren, J., Worthmann, A., Schramm, C., Kluwe, J., Ravid, R., Hornstein, E., Giladi, H. and Galun, E. (2017). Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues. Gastroenterology 153(5): 1404-1415. 
  2. Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O'Loughlin, E., Xu, Y., Fanek, Z., Greco, D. J., Smith, S. T., Tweet, G., Humulock, Z., Zrzavy, T., Conde-Sanroman, P., Gacias, M., Weng, Z., Chen, H., Tjon, E., Mazaheri, F., Hartmann, K., Madi, A., Ulrich, J. D., Glatzel, M., Worthmann, A., Heeren, J., Budnik, B., Lemere, C., Ikezu, T., Heppner, F. L., Litvak, V., Holtzman, D. M., Lassmann, H., Weiner, H. L., Ochando, J., Haass, C. and Butovsky, O. (2017). The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity 47(3): 566-581 e569.
  3. Worthmann, A., John, C., Ruhlemann, M. C., Baguhl, M., Heinsen, F. A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., Fischer, M., Dandri, M., Kremoser, C., Scheja, L., Franke, A., Shaul, P. W. and Heeren, J. (2017). Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis. Nat Med 23(7): 839-849.
  4. Bartelt, A., John, C., Schaltenberg, N., Berbee, J. F. P., Worthmann, A., Cherradi, M. L., Schlein, C., Piepenburg, J., Boon, M. R., Rinninger, F., Heine, M., Toedter, K., Niemeier, A., Nilsson, S. K., Fischer, M., Wijers, S. L., van Marken Lichtenbelt, W., Scheja, L., Rensen, P. C. N. and Heeren, J. (2017). Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport. Nat Commun 8: 15010.
  5. Berbee, J. F., Boon, M. R., Khedoe, P. P., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., Jung, C., Vazirpanah, N., Brouwers, L. P., Gordts, P. L., Esko, J. D., Hiemstra, P. S., Havekes, L. M., Scheja, L., Heeren, J. and Rensen, P. C. (2015). Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 6: 6356.
  6. John, C., Werner, P., Worthmann, A., Wegner, K., Todter, K., Scheja, L., Rohn, S., Heeren, J. and Fischer, M. (2014). A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids. J Chromatogr A 1371: 184-195.
1 Protocol published
Assessment of Uptake and Biodistribution of Radiolabeled Cholesterol in Mice Using Gavaged Recombinant Triglyceride-rich Lipoprotein Particles (rTRL)
Authors:  Anna Worthmann, Clara John and Joerg Heeren, date: 07/05/2018, view: 314, Q&A: 0
The here described method can be used to estimate the uptake of orally provided cholesterol in mice. Briefly, mice are gavaged with radiolabeled cholesterol and 4 h later, organ distribution of the radiolabel is determined by liquid scintillation ...