Michael Sieweke 1Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Germany
2 protocols

Noushin Mossadegh-Keller
  • Research associate, Centre d'Immunologie de Marseille Luminy
Research focus
  • Macrophage, Ontogeny, Testis
  • 1 Author merit


PhD, Aix-Marseille Université, 2018

Lab information

Michael Sieweke lab


  1. Noushin Mossadegh-Keller and Michael Sieweke Testicular macrophages, guardians of fertility. Cellular Immunology 2018 April 8, 330:120-125 
  2. Noushin Mossadegh-Keller, Rebecca Gentek, Gregory Gimenez, Sylvain Bigot, Sebastien Mailfert, and Michael Sieweke Developmental origin and maintenance of distinct testicular macrophage populations. JEM 2017 October 2; 214(10):2829-2841, including cover issue and shed light in Nature Immunology (October 2017): Research Highlights 18,1067
  3. Erinn L. Soucie, Ziming Weng, Laufey Geirsdóttir, Kaaweh Molawi, Julien Maurizio, Romain Fenouil, Noushin Mossadegh-Keller, Gregory Gimenez, Laurent VanHille , Meryam Beniazza, Jeremy Favret, Pierre Perrin, Nir Hacohen, J.- C. Andrau , Pierre Ferrier, Patrice Dubreuil, Arend Sidow, Michael H. Sieweke Activation of self-renewal Gene Network on a macrophage-specific enhancer platform lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Science 2016 February 12;351(6274):5510 
  4. Noushin Mossadegh-Keller, Sandrine Sarrazin, Prashanth Kandalla, Leon Espinosa, E. Richard Stanley, Stephen L.Nutt, Jordan Moore and Michael Sieweke M-CSF instructs myeloid lineage fate in single hematopoietic stem cells. Nature 2013 May 9; 497(7448):239-43 
  5. Sandrine Sarrazin, Noushin Mossadegh-Keller, Taro Fukao, Athar Aziz,Frederic Mourcin, Laurent Vanhille, Louise M. Kelly-Modis, Philippe Kastner,Susan Chan, Estelle Duprez, Claas Otto and Michael H. Sieweke MafB restricts M-CSF dependent myeloid commitment divisions of hematopoietic stem cells. Cell 2009 Jul 23; 138(2):300-13 
  6. Boukarabila H, Saurin AJ, Batsché E, Mossadegh N, van Lohuizen M, Otte AP, Pradel J, Muchardt C, Sieweke M, Duprez E. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev.2009 May 15; 23(10):1195-206 
  7. Athar Aziz, Laurent Vanhille, Peer Mohideen, Louise M. Kelly, Claas Otto, Youssef Bakri, Noushin Mossadegh-Keller, Sandrine Sarrazin, and Michael H. Sieweke (2006) Development of macrophages with altered actin organization in the absence of MafB. Mol Cell Biol.; 26(18):6808-18.
1 Protocol published
Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry
Authors:  Noushin Mossadegh-Keller and Michael H. Sieweke, date: 03/05/2019, view: 3758, Q&A: 0
Testicular macrophages (tMΦ) are the most abundant immune cells residing in the testis, an immune-privileged organ. TMΦ are known to exhibit different functions, such as protecting spermatozoa from auto-immune attack by producing immunosuppressive ...
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