Education
PhD Degree in Biomolecular sciences , University of Milan, Italy, 2014
Current position
Researcher, Biosciences, University of Milan, Italy
Publications
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Saponaro, A., Cantini, F., Porro, A., Bucchi, A., DiFrancesco, D., Maione, V., Donadoni, C., Introini, B., Mesirca, P., Mangoni, M. E., Thiel, G., Banci, L., Santoro, B. and Moroni, A. (2018). A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Elife 7.
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Gross, C., Saponaro, A., Santoro, B., Moroni, A., Thiel, G. and Hamacher, K. (2018). Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel. J Biol Chem.
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Weissgraeber, S., Saponaro, A., Thiel, G. and Hamacher, K. (2017). A reduced mechanical model for cAMP-modulated gating in HCN channels. Sci Rep 7: 40168.
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Saponaro, A., Porro, A., Chaves-Sanjuan, A., Nardini, M., Rauh, O., Thiel, G. and Moroni, A. (2017). Fusicoccin activates KAT1 channels by stabilizing their interaction with 14-3-3 proteins. Plant Cell 29(10): 2570-2580.
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Saponaro, A., Pauleta, S. R., Cantini, F., Matzapetakis, M., Hammann, C., Donadoni, C., Hu, L., Thiel, G., Banci, L., Santoro, B. and Moroni, A. (2014). Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. Proc Natl Acad Sci U S A 111(40): 14577-14582.
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Smeazzetto, S., Saponaro, A., Young, H. S., Moncelli, M. R. and Thiel, G. (2013). Structure-function relation of phospholamban: modulation of channel activity as a potential regulator of SERCA activity. PLoS One 8(1): e52744.
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Hu, L., Santoro, B., Saponaro, A., Liu, H., Moroni, A. and Siegelbaum, S. (2013). Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP. J Gen Physiol 142(6): 599-612.
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Santoro, B., Hu, L., Liu, H., Saponaro, A., Pian, P., Piskorowski, R. A., Moroni, A. and Siegelbaum, S. A. (2011). TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites. J Neurosci 31(11): 4074-4086.