Search
Coauthors
Marco Pirazzini Department of Biomedical Sciences, University of Padova, Italy, Italy,
2 protocols

Aram Megighian Department of Biomedical Sciences, University of Padova, Italy, Italy,
1 protocol

Samuele Negro Department of Biomedical Sciences, University of Padova, Italy, Italy,
2 protocols

Paola Caccin Department of Biomedical Sciences, University of Padova, Italy, Italy,
1 protocol

Giulia Zanetti
  • Department of Biomedical Sciences, University of Padova, Italy, Italy,
  • 2 Author merit

Education

Master degree, University of Padua, Padua, 2013

Current position

PhD student, Department of Biomedical Sciences of Padua, University of Padua, Padua

Publications

  1. Pirazzini, M., Azarnia Tehran, D., Zanetti, G., Rossetto, O. and Montecucco, C. (2017). Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals. Toxicon.
  2. Zanetti, G., Sikorra, S., Rummel, A., Krez, N., Duregotti, E., Negro, S., Henke, T., Rossetto, O., Binz, T. and Pirazzini, M. (2017). Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. PLoS Pathog 13(8): e1006567.
  3. Bondi, M., Germinario, E., Pirazzini, M., Zanetti, G., Cencetti, F., Donati, C., Gorza, L., Betto, R., Bruni, P. and Danieli-Betto, D. (2017). Ablation of S1P3 receptor protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity. Am J Physiol Cell Physiol 313(1): C54-C67.
  4. Azarnia Tehran, D., Zanetti, G., Leka, O., Lista, F., Fillo, S., Binz, T., Shone, C. C., Rossetto, O., Montecucco, C., Paradisi, C., Mattarei, A. and Pirazzini, M. (2015). A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins. Sci Rep 5: 17513.
  5. Duregotti, E., Zanetti, G., Scorzeto, M., Megighian, A., Montecucco, C., Pirazzini, M. and Rigoni, M. (2015). Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction. Toxins (Basel) 7(12): 5322-5336.
  6. Zanetti, G., Azarnia Tehran, D., Pirazzini, M., Binz, T., Shone, C. C., Fillo, S., Lista, F., Rossetto, O. and Montecucco, C. (2015). Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism. Biochem Pharmacol 98(3): 522-530.
  7. Pirazzini, M., Azarnia Tehran, D., Leka, O., Zanetti, G., Rossetto, O. and Montecucco, C. (2016). On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments. Biochim Biophys Acta 1858(3): 467-474.
  8. Pirazzini, M., Azarnia Tehran, D., Zanetti, G., Lista, F., Binz, T., Shone, C. C., Rossetto, O. and Montecucco, C. (2015). The thioredoxin reductase--Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles. Toxicon 107(Pt A): 32-36.
  9. Pirazzini, M., Azarnia Tehran, D., Zanetti, G., Megighian, A., Scorzeto, M., Fillo, S., Shone, C. C., Binz, T., Rossetto, O., Lista, F. and Montecucco, C. (2014). Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins. Cell Rep 8(6): 1870-1878.
2 Protocols published
Electrophysiological Recordings of Evoked End-Plate Potential on Murine Neuro-muscular Synapse Preparations
Authors:  Giulia Zanetti, Samuele Negro, Aram Megighian and Marco Pirazzini, date: 04/20/2018, view: 412, Q&A: 0
Neuromuscular junction (NMJ) is the specialized chemical synapse that mediates the transmission of the electrical impulse running along motor neuron axons to skeletal muscle fibers. NMJ is the best characterized chemical synapse and its study along ...
Mouse Phrenic Nerve Hemidiaphragm Assay (MPN)
Authors:  Giulia Zanetti, Samuele Negro, Marco Pirazzini and Paola Caccin, date: 03/05/2018, view: 479, Q&A: 0
The neuromuscular junction (NMJ) is the specialized synapse by which peripheral motor neurons innervate muscle fibers and control skeletal muscle contraction. The NMJ is the target of several xenobiotics, including chemicals, plant, animal and ...