Giusy Tornillo Cardiff University
21 protocols

Shengwen Li Children's Hospital of Orange County Research Insititute
1 protocol

Reviewer
Nandini Mondal
  • Post-Doc, Harvard Medical School
Research focus
  • Stem cell
  • Hematopoietic stem cell homing
    Mesenchymal stem cell
    Cell surface glycoengineering
    Leukocyte migration
    Cell adhesion

Education

Ph.D., State University of New York at Buffalo, 2014

Lab information

Richard D. Cummings Lab
http://harvardpeg.bwh.harvard.edu/project-1/

Publications

1. Silva M, Martin KC, Mondal N, Sackstein R. sLeX Expression Delineates Distinct Functional Subsets of Human Blood Central and Effector Memory T Cells. J Immunol. 2020 Oct 1;205(7):1920-1932. doi: 10.4049/jimmunol.1900679. Epub 2020 Aug 31. PMID: 32868410.

2. McKitrick TR, Eris D, Mondal N, Aryal RP, McCurley N, Heimburg-Molinaro J, Cummings RD. Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics. Biochemistry. 2020 Sep 1;59(34):3111-3122. doi: 10.1021/acs.biochem.9b01015. Epub 2020 Feb 27. PMID: 32052624.

3. Mondal N, Silva M, Castano AP, Maus MV, Sackstein R. Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding. J Biol Chem. 2019 Nov 29;294(48):18465-18474. doi: 10.1074/jbc.RA119.011134. Epub 2019 Oct 18. PMID: 31628196; PMCID: PMC6885642.

4. Esposito, M., Mondal, N., Greco, T. M., Wei, Y., Spadazzi, C., Lin, S.-C., . . . Kang, Y. (2019). Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nature Cell Biology, 21(5), 627-639. doi:10.1038/s41556-019-0309-2

5. Mondal, N., Dykstra, B., Lee, J., Ashline, D., Reinhold, V. N., Rossi, D. J., and Sackstein, R. (2018) Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells. Journal of Biological Chemistry

6. Donnelly, C., Dykstra, B., Mondal, N., Huang, J., Kaskow, B. J., Griffin, R., Sackstein, R., and Baecher-Allan, C. (2018) Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Scientific Reports 8, 420

7. Stolfa, G., Mondal, N., Zhu, Y., Yu, X., Buffone Jr, A., and Neelamegham, S. (2016) Using CRISPR-Cas9 to quantify the contributions of O-glycans, N-glycans and Glycosphingolipids to human leukocyte-endothelium adhesion. Scientific Reports 6, 30392

8. Mondal, N., Stolfa, G., Antonopoulos, A., Zhu, Y., Wang, S.-S., Buffone, A., Atilla-Gokcumen, G. E., Haslam, S. M., Dell, A., and Neelamegham, S. (2016) Glycosphingolipids on Human Myeloid Cells Stabilize E-Selectin–Dependent Rolling in the Multistep Leukocyte Adhesion Cascade. Arteriosclerosis, Thrombosis, and Vascular Biology 36, 718-727

9. Mondal, N., Buffone, A., Stolfa, G., Antonopoulos, A., Lau, J. T. Y., Haslam, S. M., Dell, A., and Neelamegham, S. (2015) ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes. Blood 125, 687-696

10. Mondal, N., Buffone Jr, A., and Neelamegham, S. (2013) Distinct glycosyltransferases synthesize E-selectin ligands in human vs. mouse leukocytes. Cell Adhesion & Migration 7, 288-292

11. Buffone, A., Mondal, N., Gupta, R., McHugh, K. P., Lau, J. T. Y., and Neelamegham, S. (2013) Silencing α1,3-Fucosyltransferases in Human Leukocytes Reveals a Role for FUT9 Enzyme during E-selectin-mediated Cell Adhesion. Journal of Biological Chemistry 288, 1620-1633

12. Chinthamani, S., Odusanwo, O., Mondal, N., Nelson, J., Neelamegham, S., and Baker, O. J. (2012) Lipoxin A4 inhibits immune cell binding to salivary epithelium and vascular endothelium. American Journal of Physiology-Cell Physiology 302, C968-C978

13. Dayananda, K. M., Singh, I., Mondal, N., and Neelamegham, S. (2010) von Willebrand factor self-association on platelet GpIbα under hydrodynamic shear: effect on shear-induced platelet activation. Blood 116, 3990-3998
2 Protocols reviewed
Generation of the Compression-induced Dedifferentiated Adipocytes (CiDAs) Using Hypertonic Medium

Current methods to obtain mesenchymal stem cells (MSCs) involve sampling, culturing, and expanding of primary MSCs from adipose, bone marrow, and umbilical cord tissues. However, the drawbacks are the limited numbers of total cells in MSC pools, and

...
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Cobblestone Area-forming Cell Assay of Mouse Bone Marrow Hematopoietic Stem Cells
Authors:  Surya Amarachintha and Qishen Pang, date: 05/05/2018, view: 6965, Q&A: 0
Bone Marrow Hematopoietic Stem Cells (HSCs) require bone marrow microenvironment for their maintenance and proliferation. Culture of Bone Marrow Mesenchymal Stromal Cells (MSCs) provides appropriate environmental signals for HSCs survival in vitro ...
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