Samuel Petshow Integrative Biosciences, Oregon Health and Science University, USA, USA,
1 protocol

Marcel Wehrli
  • Integrative Biosciences, Oregon Health and Science University, USA, USA,
Research focus
  • Developmental biology
  • 1 Author merit


Ph.D. (D. Phil. II), University of Zurich (performed at the MRC-Laboratory of Molecular Biology, Cambridge, UK), Switzerland, 1993

Current position

Associate Professor, Dept. of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon, USA


  1. Sopory, S., Kwon, S., Wehrli, M. and Christian, J. L. (2010). Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain. Dev Biol 346(1): 102-112.
  2. Kremer, S. A., Erdeniz, N., Peterson-Nedry, W. P., Swanson, E. A. and Wehrli, M. (2010). Mutations in Axin contact amino acids causes phenotypes ranging from severe to wild type. Developmental Biology 337: 110-23.
  3. Peterson-Nedry, W., Erdeniz, N., Kremer, S., Yu, J., Baig-Lewis, S. and Wehrli, M. (2008). Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo. Dev Biol 320(1): 226-241.
  4. Baig-Lewis, S., Peterson-Nedry, W. and Wehrli, M. (2007). Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP. Dev Biol 306(1): 94-111.
  5. Rives, A. F., Rochlin, K. M., Wehrli, M., Schwartz, S. L. and DiNardo, S. (2006). Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing. Dev Biol 293(1): 268-283.
  6. Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S. and Wieschaus, E. (2003). Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev Cell 4(3): 407-418.
  7. Wehrli, M., Dougan, S. T., Caldwell, K., O'Keefe, L., Schwartz, S., Vaizel-Ohayon, D., Schejter, E., Tomlinson, A. and DiNardo, S. (2000). arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407(6803): 527-530.
  8. Wehrli, M. and Tomlinson, A. (1998). Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development 125(8): 1421-1432.
  9. Wehrli, M. and Tomlinson, A. (1995). Epithelial planar polarity in the developing Drosophila eye. Development 121(8): 2451-2459.
  10. Brower, D. L., Bunch, T. A., Mukai, L., Adamson, T. E., Wehrli, M., Lam, S., Friedlander, E., Roote, C. E. and Zusman, S. (1995). Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the alpha PS1 integrin subunit. Development 121(5): 1311-1320.
  11. Gotwals, P. J., Fessler, L. I., Wehrli, M. and Hynes, R. O. (1994). Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2. Proc Natl Acad Sci U S A 91(24): 11447-11451.
  12. Wehrli, M., DiAntonio, A., Fearnley, I. M., Smith, R. J. and Wilcox, M. (1993). Cloning and characterization of alpha PS1, a novel Drosophila melanogaster integrin. Mech Dev 43(1): 21-36.
  13. Wessendorf, L. H., Wehrli, M., DiAntonio, A. and Wilcox, M. (1992). Genetic interactions with integrins during wing morphogenesis in Drosophila. Cold Spring Harb Symp Quant Biol 57: 241-248.
1 Protocol published
Authors:  Samuel Petshow and Marcel Wehrli, date: 02/05/2018, view: 6908, Q&A: 0
The combination of immunofluorescence and laser scanning confocal microscopy (LSM) is essential to high-resolution detection of molecular distribution in biological specimens. A frequent limitation is the need to image deep inside a tissue or in a ...
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