Sophie Figueiredo Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpêtrière, France, France,
1 protocol

Olivier Thouvenin Institut du cerveau et de la moelle épinière (ICM), UPMC, France, France,
1 protocol

Andrew Prendergast Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpêtrière, France, France,
1 protocol

Steven Knafo Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpêtrière, France, France,
1 protocol

Claire Wyart
  • Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpêtrière, France, France,
  • 1 Author merit


PhD, University of Strasbourg, France, 2003

Current position

Group Leader, Neurophysiology, Institut du Cerveau et de la Moelle épinière (ICM), France

Publications (selected)

  1. Knafo, S., Fidelin, K., Prendergast, A., Tseng, P. B., Parrin, A., Dickey, C., Bohm, U. L., Figueiredo, S. N., Thouvenin, O., Pascal-Moussellard, H. and Wyart, C. (2017). Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. Elife 6.
  2. Djenoune, L., Desban, L., Gomez, J., Sternberg, J. R., Prendergast, A., Langui, D., Quan, F. B., Marnas, H., Auer, T. O., Rio, J. P., Del Bene, F., Bardet, P. L. and Wyart, C. (2017). The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Sci Rep 7(1): 719.
  3. Hubbard, J. M., Bohm, U. L., Prendergast, A., Tseng, P. B., Newman, M., Stokes, C. and Wyart, C. (2016). Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion. Curr Biol 26(21): 2841-2853.
  4. Sternberg, J. R., Severi, K. E., Fidelin, K., Gomez, J., Ihara, H., Alcheikh, Y., Hubbard, J. M., Kawakami, K., Suster, M. and Wyart, C. (2016). Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo. Curr Biol 26(17): 2319-2328.
  5. Hernandez, O., Papagiakoumou, E., Tanese, D., Fidelin, K., Wyart, C. and Emiliani, V. (2016). Three-dimensional spatiotemporal focusing of holographic patterns. Nat Commun 7: 11928.
  6. Rupprecht, P., Prendergast, A., Wyart, C. and Friedrich, R. W. (2016). Remote z-scanning with a macroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy. Biomed Opt Express 7(5): 1656-1671.
  7. Bohm, U. L., Prendergast, A., Djenoune, L., Nunes Figueiredo, S., Gomez, J., Stokes, C., Kaiser, S., Suster, M., Kawakami, K., Charpentier, M., Concordet, J. P., Rio, J. P., Del Bene, F. and Wyart, C. (2016). CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nat Commun 7: 10866.
  8. Fidelin, K., Djenoune, L., Stokes, C., Prendergast, A., Gomez, J., Baradel, A., Del Bene, F. and Wyart, C. (2015). State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons. Curr Biol 25(23): 3035-3047.
  9. Auer, T. O., Xiao, T., Bercier, V., Gebhardt, C., Duroure, K., Concordet, J. P., Wyart, C., Suster, M., Kawakami, K., Wittbrodt, J., Baier, H. and Del Bene, F. (2015). Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. Elife 4.
  10. De Vico Fallani, F., Corazzol, M., Sternberg, J., Wyart, C. and Chavez, M. (2015). Hierarchy of neural organization in the embryonic spinal cord: Granger-Causality graph analysis of in vivo calcium imaging data. IEEE Trans Neural Syst Rehabil Eng 23(3): 333-41.
  11. Quan, F. B., Dubessy, C., Galant, S., Kenigfest, N. B., Djenoune, L., Leprince, J., Wyart, C., Lihrmann, I. and Tostivint, H. (2015). Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons. PLoS One 10(3): e0119290.
  12. Lauterbach, M. A., Ronzitti, E., Sternberg, J. R., Wyart, C. and Emiliani, V. (2015). Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy. PLoS One 10(12): e0143681.
  13. Goetz, J. G., Steed, E., Ferreira, R. R., Roth, S., Ramspacher, C., Boselli, F., Charvin, G., Liebling, M., Wyart, C., Schwab, Y. and Vermot, J. (2014). Endothelial cilia mediate low flow sensing during zebrafish vascular development. Cell Rep 6(5): 799-808.
  14. Djenoune, L., Khabou, H., Joubert, F., Quan, F. B., Nunes Figueiredo, S., Bodineau, L., Del Bene, F., Burckle, C., Tostivint, H. and Wyart, C. (2014). Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates. Front Neuroanat 8: 26.
  15. Mirat, O., Sternberg, J. R., Severi, K. E. and Wyart, C. (2013). ZebraZoom: an automated program for high-throughput behavioral analysis and categorization. Front Neural Circuits 7: 107.
  16. Hong, E., Santhakumar, K., Akitake, C. A., Ahn, S. J., Thisse, C., Thisse, B., Wyart, C., Mangin, J. M. and Halpern, M. E. (2013). Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proc Natl Acad Sci U S A 110(52): 21171-21176.
  17. Warp, E., Agarwal, G., Wyart, C., Friedmann, D., Oldfield, C. S., Conner, A., Del Bene, F., Arrenberg, A. B., Baier, H. and Isacoff, E. Y. (2012). Emergence of patterned activity in the developing zebrafish spinal cord. Curr Biol 22(2): 93-102.
  18. Del Bene, F., Wyart, C., Robles, E., Tran, A., Looger, L., Scott, E. K., Isacoff, E. Y. and Baier, H. (2010). Filtering of visual information in the tectum by an identified neural circuit. Science 330(6004): 669-673.
  19. Janovjak, H., Szobota, S., Wyart, C., Trauner, D. and Isacoff, E. Y. (2010). A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nat Neurosci 13(8): 1027-1032.
  20. Wyart, C., Del Bene, F., Warp, E., Scott, E. K., Trauner, D., Baier, H. and Isacoff, E. Y. (2009). Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature 461(7262): 407-410.
  21. Pautot, S., Wyart, C. and Isacoff, E. Y. (2008). Colloid-guided assembly of oriented 3D neuronal networks. Nature Methods 5: 735-740.
  22. Szobota, S., Gorostiza, P., Del Bene, F., Wyart, C., Fortin, D. L., Kolstad, K. D., Tulyathan, O., Volgraf, M., Numano, R., Aaron, H. L., Scott, E. K., Kramer, R. H., Flannery, J., Baier, H., Trauner, D. and Isacoff, E. Y. (2007). Remote control of neuronal activity with a light-gated glutamate receptor. Neuron 54(4): 535-545.
  23. Wyart, C., Webster, W. W., Chen, J. H., Wilson, S. R., McClary, A., Khan, R. M. and Sobel, N. (2007). Smelling a single component of male sweat alters levels of cortisol in women. J Neurosci 27(6): 1261-1265.
  24. Salome, R., Kremer, Y., Dieudonne, S., Leger, J. F., Krichevsky, O., Wyart, C., Chatenay, D. and Bourdieu, L. (2006). Ultrafast random-access scanning in two-photon microscopy using acousto-optic deflectors. J Neurosci Methods 154(1-2): 161-174.
  25. Wyart, C., Cocco, S., Bourdieu, L., Leger, J. F., Herr, C. and Chatenay, D. (2005). Dynamics of excitatory synaptic components in sustained firing at low rates. J Neurophysiol 93(6): 3370-3380.
  26. Wyart, C., Ybert, C., Bourdieu, L., Herr, C., Prinz, C. and Chatenay, D. (2002). Constrained synaptic connectivity in functional mammalian neuronal networks grown on patterned surfaces. J Neurosci Methods 117(2): 123-131.
  27. Knowles, R. B., Wyart, C., Buldyrev, S. V., Cruz, L., Urbanc, B., Hasselmo, M. E., Stanley, H. E. and Hyman, B. T. (1999). Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease. Proc Natl Acad Sci U S A 96(9): 5274-5279.
1 Protocol published
Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae
The proof of concept for bioluminescence monitoring of neural activity in zebrafish with the genetically encoded calcium indicator GFP-aequorin has been previously described (Naumann et al., 2010) but challenges remain. First, ...
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