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Coauthors
Catarina Henriques Department of Oncology & Metabolism, University of Sheffield, UK, UK,
1 protocol

Mirre Simons Bateson Centre, University of Sheffield, UK, UK,
1 protocol

Andrew McCracken Bateson Centre, University of Sheffield, UK, UK,
1 protocol

Raquel Martins Department of Oncology & Metabolism, University of Sheffield, UK, UK,
1 protocol

Michael Rera
  • Research scientist, UMR8256, Sorbonne Université/CNRS, Paris
Research focus
  • Ageing
  • Understanding ageing looking at the end of life
  • 1 Author merit

Education

PhD, Université Paris-Diderot, 2010

Lab information

Rera Lab

Publications

Anil Rana, Matheus P. Oliveira, Andy V. Khamoui, Ricardo Aparicio, Michael Rera, Harry B. Rossiter, David W. Walker: Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. Nature Communications 12/2017; 8(1)., DOI:10.1038/s41467-017-00525-4
Michael Rera, Céline Vallot, Christel Lefrançois: The Smurf transition: New insights on ageing from end-of-life studies in animal models. Current Opinion in Oncology 10/2017; 30(1):1., DOI:10.1097/CCO.0000000000000419
Emilie Dambroise, Léa Monnier, Lu Ruisheng, Hugo Aguilaniu, Jean-Stéphane Joly, Hervé Tricoire, Michael Rera: Two phases of aging separated by the Smurf transition as a public path to death. Scientific Reports 03/2016; 6., DOI:10.1038/srep23523
Hervé Tricoire, Michael Rera: A New, Discontinuous 2 Phases of Aging Model: Lessons from Drosophila melanogaster. PLoS ONE 11/2015; 10(11):e0141920., DOI:10.1371/journal.pone.0141920
Alexandra Seguin, Véronique Monnier, Amandine Palandri, Frédéric Bihel, Michael Rera, Martine Schmitt, Jean-Michel Camadro, Hervé Tricoire, Emmanuel Lesuisse: A Yeast/ Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency. Oxidative medicine and cellular longevity 10/2015; 2015(1):1-10., DOI:10.1155/2015/565140
Emilie Dambroise, Léa Monnier, Lu Ruisheng, Hugo Aguilaniu, Jean-Stéphane Joly, Hervé Tricoire, Michael Rera: Two phases of aging separated by the Smurf transition as a public path to death. DOI:10.1101/028183
Rebecca Ivy Clark, Anna Salazar, Ryuichi Yamada, Sorel Fitz-Gibbon, Marco Morselli, Jeanette Alcaraz, Anil Rana, Michael Rera, Matteo Pellegrini, William W Ja, David W Walker: Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality. Cell Reports 08/2015; 12(10):1-12., DOI:10.1016/j.celrep.2015.08.004
Hervé Tricoire, Michael Rera: Modelizing Drosophila melanogaster longevity curves using a new discontinuous 2-Phases of Aging model. DOI:10.1101/025411
Matthew Ulgherait, Anil Rana, Michael Rera, Jacqueline Graniel, David W Walker: AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner. Cell Reports 09/2014; 8(6)., DOI:10.1016/j.celrep.2014.08.006
Jae H Hur, Sepehr Bahadorani, Jacqueline Graniel, Christopher L Koehler, Matthew Ulgherait, Michael Rera, D Leanne Jones, David W Walker: Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells. Aging 09/2013; 5(9)., DOI:10.18632/aging.100595
Michael Rera, Rebecca I Clark, David W Walker: Why do old flies die?. Aging 08/2013; 5(8)., DOI:10.18632/aging.100589
Anil Rana, Michael Rera, David W Walker: Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proceedings of the National Academy of Sciences 05/2013; 110(21)., DOI:10.1073/pnas.1216197110
Michael Rera, Rebecca I Clark, David W Walker: Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proceedings of the National Academy of Sciences 12/2012; 109(52)., DOI:10.1073/pnas.1215849110
Véronique Monnier, Magali Iché-Torres, Michael Rera, Vincent Contremoulins, Céline Guichard, Nathalie Lalevée, Hervé Tricoire, Laurent Perrin: dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila. PLoS Genetics 11/2012; 8(11):e1003081., DOI:10.1371/journal.pgen.1003081
Michael Rera, Masoud J Azizi, David W Walker: Organ-specific mediation of lifespan extension: More than a gut feeling?. Ageing research reviews 06/2012; 12(1)., DOI:10.1016/j.arr.2012.05.003
Michael Rera, Sepehr Bahadorani, Jaehyoung Cho, Christopher L Koehler, Matthew Ulgherait, Jae H Hur, William S Ansari, Thomas Lo, D Leanne Jones, David W Walker: Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog. Cell metabolism 11/2011; 14(5):623-34., DOI:10.1016/j.cmet.2011.09.013
Michael Rera, Véronique Monnier, Hervé Tricoire: Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster. Mechanisms of ageing and development 02/2010; 131(2):156-64., DOI:10.1016/j.mad.2010.01.004

1 Protocol published
How to Catch a Smurf? – Ageing and Beyond…
In vivo Assessment of Intestinal Permeability in Multiple Model Organisms

The Smurf Assay (SA) was initially developed in the model organism Drosophila melanogaster where a dramatic increase of intestinal permeability has been shown to occur during aging (Rera et al., 2011). We have since validated the ...