Carole Rovère Université Côte d'Azur-CNRS, Institute of Molecular and Cellular Pharmacology , France, France,
1 protocol

Ophélia Le Thuc Technische Universität München (TUM), Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Germany, Germany,
1 protocol

Jacques Noël
  • Université Côte d'Azur-CNRS, Institute of Molecular and Cellular Pharmacology, France, France,
Research focus
  • Neuroscience
  • 1 Author merit


Ph.D in Cell Biology, Université Paris-Sud Orsay, France, 1993

Current position

Professor in Neurosciences and innovative technologies, Department of Biotechnologies, Engineering Scholl Polytech Nice Sophia, University of Nice Sophia Antipolis, University Cote d’Azur, France

Publications (2011)

  1. Marra, S., Ferru-Clement, R., Breuil, V., Delaunay, A., Christin, M., Friend, V., Sebille, S., Cognard, C., Ferreira, T., Roux, C., Euller-Ziegler, L., Noel, J., Lingueglia, E. and Deval, E. (2016). Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids. EMBO J 35(4): 414-428.
  2. Lolignier, S., Gkika, D., Andersson, D., Leipold, E., Vetter, I., Viana, F., Noel, J. and Busserolles, J. (2016). New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives. J Neurosci 36(45): 11435-11439.
  3. Busserolles, J. and Noël, J. (2016). La douleur sous le contrôle des canaux potassiques. Douleur et Analgésie 29(4): 204-211.
  4. Lolignier, S., Bonnet, C., Gaudioso, C., Noel, J., Ruel, J., Amsalem, M., Ferrier, J., Rodat-Despoix, L., Bouvier, V., Aissouni, Y., Prival, L., Chapuy, E., Padilla, F., Eschalier, A., Delmas, P. and Busserolles, J. (2015). The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia. Cell Rep 11(7): 1067-1078.
  5. Francois, A., Schuetter, N., Laffray, S., Sanguesa, J., Pizzoccaro, A., Dubel, S., Mantilleri, A., Nargeot, J., Noel, J., Wood, J. N., Moqrich, A., Pongs, O. and Bourinet, E. (2015). The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. Cell Rep.
  6. Pereira, V., Busserolles, J., Christin, M., Devilliers, M., Poupon, L., Legha, W., Alloui, A., Aissouni, Y., Bourinet, E., Lesage, F., Eschalier, A., Lazdunski, M. and Noel, J. (2014). Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception. Pain 155(12): 2534-2544.
  7. Devilliers, M., Busserolles, J., Lolignier, S., Deval, E., Pereira, V., Alloui, A., Christin, M., Mazet, B., Delmas, P., Noel, J., Lazdunski, M. and Eschalier, A. (2013). Activation of TREK-1 by morphine results in analgesia without adverse side effects. Nat Commun 4: 2941.
  8. Hao, J., Padilla, F., Dandonneau, M., Lavebratt, C., Lesage, F., Noel, J. and Delmas, P. (2013). Kv1.1 channels act as mechanical brake in the senses of touch and pain. Neuron 77(5): 899-914.
  9. Delaunay, A., Gasull, X., Salinas, M., Noel, J., Friend, V., Lingueglia, E. and Deval, E. (2012). Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions. Proc Natl Acad Sci U S A 109(32): 13124-13129.
  10. Baron, A., Diochot, S., Salinas, M., Deval, E., Noel, J. and Lingueglia, E. (2013). Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels. Toxicon 75: 187-204.
  11. Deval, E., Noel, J., Gasull, X., Delaunay, A., Alloui, A., Friend, V., Eschalier, A., Lazdunski, M. and Lingueglia, E. (2011). Acid-sensing ion channels in postoperative pain. J Neurosci 31(16): 6059-6066.
  12. Descoeur, J., Pereira, V., Pizzoccaro, A., Francois, A., Ling, B., Maffre, V., Couette, B., Busserolles, J., Courteix, C., Noel, J., Lazdunski, M., Eschalier, A., Authier, N. and Bourinet, E. (2011). Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med 3(5): 266-278.
  13. Descoeur, J., Pereira, V., Pizzoccaro, A., François, A., Ling, B., Maffre, V., Couette, B., Busserolles, J., Courteix, C., Noël, J., Lazdunski, M., Eschalier, A., Authier, N. and Bourinet, E. (2011). Implication des canaux ioniques dans l'hypersensibilité au froid induite par l'oxaliplatine. Cancéro digest 3(3): 215-217.
  14. Appleby, V. J., Correa, S. A., Duckworth, J. K., Nash, J. E., Noel, J., Fitzjohn, S. M., Collingridge, G. L. and Molnar, E. (2011). LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression. J Neurochem 116(4): 530-543.
  15. Deval, E., Gasull, X., Noel, J., Salinas, M., Baron, A., Diochot, S. and Lingueglia, E. (2010). Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol Ther 128(3): 549-558.
  16. Beraud-Dufour, S., Abderrahmani, A., Noel, J., Brau, F., Waeber, G., Mazella, J. and Coppola, T. (2010). Neurotensin is a regulator of insulin secretion in pancreatic beta-cells. Int J Biochem Cell Biol 42(10): 1681-1688.
  17. Noel, J., Salinas, M., Baron, A., Diochot, S., Deval, E. and Lingueglia, E. (2010). Current perspectives on acid-sensing ion channels: new advances and therapeutic implications. Expert Rev Clin Pharmacol 3(3): 331-346.
  18. Noel, J., Zimmermann, K., Busserolles, J., Deval, E., Alloui, A., Diochot, S., Guy, N., Borsotto, M., Reeh, P., Eschalier, A. and Lazdunski, M. (2009). The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J 28(9): 1308-1318.
  19. Deval, E., Noel, J., Lay, N., Alloui, A., Diochot, S., Friend, V., Jodar, M., Lazdunski, M. and Lingueglia, E. (2008). ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J 27(22): 3047-3055.
1 Protocol published
An ex vivo Perifusion Method for Quantitative Determination of Neuropeptide Release from Mouse Hypothalamic Explants
Authors:  Ophélia Le Thuc, Jacques Noël and Carole Rovère, date: 08/20/2017, view: 5732, Q&A: 0
The hypothalamus is a primary brain area which, in mammals, regulates several physiological functions that are all related to maintaining general homeostasis, by linking the central nervous system (CNS) and the periphery. The hypothalamus itself can ...
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