Carole Rovère Université Côte d'Azur-CNRS, Institute of Molecular and Cellular Pharmacology , France, France,
1 protocol

Jacques Noël Université Côte d'Azur-CNRS, Institute of Molecular and Cellular Pharmacology, France, France,
1 protocol

Ophélia Le Thuc
  • Technische Universität München (TUM), Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Germany, Germany,
Research focus
  • Neuroscience
  • 1 Author merit


PhD in Neurosciences, University Nice Sophia Antipolis, France, 2015

Current position

Post-doctoral research fellow, Institute for Diabetes and Obesity, TUM/Helmholtz Diabetes Center, Munich, Germany


  1. Le Thuc, O. and Rovere, C. (2016). Hypothalamic inflammation and energy balance deregulations: focus on chemokines. Biol Aujourdhui 210(4): 211-225.
  2. Mequinion, M., Le Thuc, O., Zgheib, S., Alexandre, D., Chartrel, N., Rovere, C., Hardouin, P., Viltart, O. and Chauveau, C. (2016). Long-Term Energy Deficit in Mice Causes Long-Lasting Hypothalamic Alterations after Recovery. Neuroendocrinology.
  3. Le Thuc, O., Cansell, C., Bourourou, M., Denis, R. G., Stobbe, K., Devaux, N., Guyon, A., Cazareth, J., Heurteaux, C., Rostene, W., Luquet, S., Blondeau, N., Nahon, J. L. and Rovere, C. (2016). Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation. EMBO Rep 17(12): 1738-1752.
  4. Garcia-Caceres, C., Quarta, C., Varela, L., Gao, Y., Gruber, T., Legutko, B., Jastroch, M., Johansson, P., Ninkovic, J., Yi, C. X., Le Thuc, O., Szigeti-Buck, K., Cai, W., Meyer, C. W., Pfluger, P. T., Fernandez, A. M., Luquet, S., Woods, S. C., Torres-Aleman, I., Kahn, C. R., Gotz, M., Horvath, T. L. and Tschop, M. H. (2016). Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell 166(4): 867-880.
  5. Lebeaupin, C., Proics, E., de Bieville, C. H., Rousseau, D., Bonnafous, S., Patouraux, S., Adam, G., Lavallard, V. J., Rovere, C., Le Thuc, O., Saint-Paul, M. C., Anty, R., Schneck, A. S., Iannelli, A., Gugenheim, J., Tran, A., Gual, P. and Bailly-Maitre, B. (2015). ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell Death Dis 6: e1879.
  6. Le Thuc, O., Blondeau, N., Nahon, J. L. and Rovere, C. (2015). The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects. Ann N Y Acad Sci 1351: 127-140.
  7. Schneck, A. S., Iannelli, A., Patouraux, S., Rousseau, D., Bonnafous, S., Bailly-Maitre, B., Le Thuc, O., Rovere, C., Panaia-Ferrari, P., Anty, R., Tran, A., Gual, P. and Gugenheim, J. (2014). Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots. Surg Endosc 28(2): 592-602.
  8. Lauritzen, I., Pardossi-Piquard, R., Bauer, C., Brigham, E., Abraham, J. D., Ranaldi, S., Fraser, P., St-George-Hyslop, P., Le Thuc, O., Espin, V., Chami, L., Dunys, J. and Checler, F. (2012). The beta-secretase-derived C-terminal fragment of betaAPP, C99, but not Abeta, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci 32(46): 16243-11655a.
1 Protocol published
An ex vivo Perifusion Method for Quantitative Determination of Neuropeptide Release from Mouse Hypothalamic Explants
Authors:  Ophélia Le Thuc, Jacques Noël and Carole Rovère, date: 08/20/2017, view: 5577, Q&A: 0
The hypothalamus is a primary brain area which, in mammals, regulates several physiological functions that are all related to maintaining general homeostasis, by linking the central nervous system (CNS) and the periphery. The hypothalamus itself can ...
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