Education
PhD in Neurosciences, University Nice Sophia Antipolis, France, 2015
Current position
Post-doctoral research fellow, Institute for Diabetes and Obesity, TUM/Helmholtz Diabetes Center, Munich, Germany
Publications
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Le Thuc, O. and Rovere, C. (2016). Hypothalamic inflammation and energy balance deregulations: focus on chemokines. Biol Aujourdhui 210(4): 211-225.
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Mequinion, M., Le Thuc, O., Zgheib, S., Alexandre, D., Chartrel, N., Rovere, C., Hardouin, P., Viltart, O. and Chauveau, C. (2016). Long-Term Energy Deficit in Mice Causes Long-Lasting Hypothalamic Alterations after Recovery. Neuroendocrinology.
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Le Thuc, O., Cansell, C., Bourourou, M., Denis, R. G., Stobbe, K., Devaux, N., Guyon, A., Cazareth, J., Heurteaux, C., Rostene, W., Luquet, S., Blondeau, N., Nahon, J. L. and Rovere, C. (2016). Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation. EMBO Rep 17(12): 1738-1752.
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Garcia-Caceres, C., Quarta, C., Varela, L., Gao, Y., Gruber, T., Legutko, B., Jastroch, M., Johansson, P., Ninkovic, J., Yi, C. X., Le Thuc, O., Szigeti-Buck, K., Cai, W., Meyer, C. W., Pfluger, P. T., Fernandez, A. M., Luquet, S., Woods, S. C., Torres-Aleman, I., Kahn, C. R., Gotz, M., Horvath, T. L. and Tschop, M. H. (2016). Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell 166(4): 867-880.
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Lebeaupin, C., Proics, E., de Bieville, C. H., Rousseau, D., Bonnafous, S., Patouraux, S., Adam, G., Lavallard, V. J., Rovere, C., Le Thuc, O., Saint-Paul, M. C., Anty, R., Schneck, A. S., Iannelli, A., Gugenheim, J., Tran, A., Gual, P. and Bailly-Maitre, B. (2015). ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell Death Dis 6: e1879.
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Le Thuc, O., Blondeau, N., Nahon, J. L. and Rovere, C. (2015). The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects. Ann N Y Acad Sci 1351: 127-140.
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Schneck, A. S., Iannelli, A., Patouraux, S., Rousseau, D., Bonnafous, S., Bailly-Maitre, B., Le Thuc, O., Rovere, C., Panaia-Ferrari, P., Anty, R., Tran, A., Gual, P. and Gugenheim, J. (2014). Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots. Surg Endosc 28(2): 592-602.
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Lauritzen, I., Pardossi-Piquard, R., Bauer, C., Brigham, E., Abraham, J. D., Ranaldi, S., Fraser, P., St-George-Hyslop, P., Le Thuc, O., Espin, V., Chami, L., Dunys, J. and Checler, F. (2012). The beta-secretase-derived C-terminal fragment of betaAPP, C99, but not Abeta, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci 32(46): 16243-11655a.