Charles Cox Pediatric Surgery, University of Texas McGovern Medical School, U.S.A, U.S.A,
1 protocol

Scott Olson Pediatric Surgery, University of Texas McGovern Medical School, U.S.A, U.S.A,
1 protocol

Siobahn Evans 1 protocol

Miguel Diaz Pediatric Surgery, University of Texas McGovern Medical School, U.S.A., U.S.A.,
1 protocol

Pamela L. Wenzel
  • Pediatric Surgery, University of Texas McGovern Medical School, U.S.A, U.S.A,
Research focus
  • Stem cell
  • 1 Author merit


Ph.D., The Ohio State University, U.S.A

Current position

Assistant Professor of Pediatric Surgery, Pediatric Surgery, The University of Texas Health Science Center at Houston, U.S.A

Publications (since 2003)

  1. Lee, H. J., Diaz, M. F., Ewere, A., Olson, S. D., Cox, C. S., Jr. and Wenzel, P. L. (2017). Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force. Cell Signal 38: 1-9.
  2. Lee, H. J., Diaz, M. F., Price, K. M., Ozuna, J. A., Zhang, S., Sevick-Muraca, E. M., Hagan, J. P. and Wenzel, P. L. (2017). Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun 8: 14122.
  3. Diaz, M. F., Vaidya, A. B., Evans, S. M., Lee, H. J., Aertker, B. M., Alexander, A. J., Price, K. M., Ozuna, J. A., Liao, G. P., Aroom, K. R., Xue, H., Gu, L., Omichi, R., Bedi, S., Olson, S. D., Cox, C. S., Jr. and Wenzel, P. L. (2017). Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells. Stem Cells 35(5): 1259-1272.
  4. Kota, D. J., Prabhakara, K. S., Toledano-Furman, N., Bhattarai, D., Chen, Q., DiCarlo, B., Smith, P., Triolo, F., Wenzel, P. L., Cox, C. S., Jr. and Olson, S. D. (2017). Prostaglandin E2 Indicates Therapeutic Efficacy of Mesenchymal Stem Cells in Experimental Traumatic Brain Injury. Stem Cells 35(5): 1416-1430.
  5. Diaz, M. F., Li, N., Lee, H. J., Adamo, L., Evans, S. M., Willey, H. E., Arora, N., Torisawa, Y. S., Vickers, D. A., Morris, S. A., Naveiras, O., Murthy, S. K., Ingber, D. E., Daley, G. Q., Garcia-Cardena, G. and Wenzel, P. L. (2015). Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med 212(5): 665-680.
  6. Jang, I. H., Lu, Y. F., Zhao, L., Wenzel, P. L., Kume, T., Datta, S. M., Arora, N., Guiu, J., Lagha, M., Kim, P. G., Do, E. K., Kim, J. H., Schlaeger, T. M., Zon, L. I., Bigas, A., Burns, C. E. and Daley, G. Q. (2015). Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood 125(9): 1418-1426.
  7. Li, N., Diaz, M. F. and Wenzel, P. L. (2015). Application of fluid mechanical force to embryonic sources of hemogenic endothelium and hematopoietic stem cells. Methods Mol Biol 1212: 183-193.
  8. Arora, N., Wenzel, P. L., McKinney-Freeman, S. L., Ross, S. J., Kim, P. G., Chou, S. S., Yoshimoto, M., Yoder, M. C. and Daley, G. Q. (2014). Effect of developmental stage of HSC and recipient on transplant outcomes. Dev Cell 29(5): 621-628.
  9. Lee, H. J., Li, N., Evans, S. M., Diaz, M. F. and Wenzel, P. L. (2013). Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling. Differentiation 86(3): 92-103.
  10. Gustafsson, K., Heffner, G., Wenzel, P. L., Curran, M., Grawe, J., McKinney-Freeman, S. L., Daley, G. Q. and Welsh, M. (2013). The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp Cell Res 319(12): 1852-1864.
  11. Ouseph, M. M., Li, J., Chen, H. Z., Pecot, T., Wenzel, P., Thompson, J. C., Comstock, G., Chokshi, V., Byrne, M., Forde, B., Chong, J. L., Huang, K., Machiraju, R., de Bruin, A. and Leone, G. (2012). Atypical E2F repressors and activators coordinate placental development. Dev Cell 22(4): 849-862.
  12. Wenzel, P. L., Chong, J. L., Saenz-Robles, M. T., Ferrey, A., Hagan, J. P., Gomez, Y. M., Rajmohan, R., Sharma, N., Chen, H. Z., Pipas, J. M., Robinson, M. L. and Leone, G. (2011). Cell proliferation in the absence of E2F1-3. Dev Biol 351(1): 35-45.
  13. Chen, D., Pacal, M., Wenzel, P., Knoepfler, P. S., Leone, G. and Bremner, R. (2009). Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275): 925-929.
  14. Chong, J. L., Wenzel, P. L., Saenz-Robles, M. T., Nair, V., Ferrey, A., Hagan, J. P., Gomez, Y. M., Sharma, N., Chen, H. Z., Ouseph, M., Wang, S. H., Trikha, P., Culp, B., Mezache, L., Winton, D. J., Sansom, O. J., Chen, D., Bremner, R., Cantalupo, P. G., Robinson, M. L., Pipas, J. M. and Leone, G. (2009). E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 462(7275): 930-934.
  15. Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F. and Daley, G. Q. (2009). Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 460(7252): 259-263.
  16. Adamo, L., Naveiras, O., Wenzel, P. L., McKinney-Freeman, S., Mack, P. J., Gracia-Sancho, J., Suchy-Dicey, A., Yoshimoto, M., Lensch, M. W., Yoder, M. C., Garcia-Cardena, G. and Daley, G. Q. (2009). Biomechanical forces promote embryonic haematopoiesis. Nature 459(7250): 1131-1135.
  17. Mosaliganti, K., Pan, T., Ridgway, R., Sharp, R., Cooper, L., Gulacy, A., Sharma, A., Irfanoglu, O., Machiraju, R., Kurc, T., de Bruin, A., Wenzel, P., Leone, G., Saltz, J. and Huang, K. (2008). An imaging workflow for characterizing phenotypical change in large histological mouse model datasets. J Biomed Inform 41(6): 863-873.
  18. Mosaliganti, K., Janoos, F., Sharp, R., Ridgway, R., Machiraju, R., Huang, K., Wenzel, P., deBruin, A., Leone, G. and Saltz, J. (2007). Detection and visualization of surface-pockets to enable phenotyping studies. IEEE Trans Med Imaging 26(9): 1283-1290.
  19. Chen, D., Opavsky, R., Pacal, M., Tanimoto, N., Wenzel, P., Seeliger, M. W., Leone, G. and Bremner, R. (2007). Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol 5(7): e179.
  20. Wenzel, P. L. and Leone, G. (2007). Expression of Cre recombinase in early diploid trophoblast cells of the mouse placenta. Genesis 45(3): 129-134.
  21. Wenzel, P. L. (2007). Role of the Rb tumor suppressor in regulation of stem cell proliferation. Scitizen.
  22. Sharp, R., Ridgway, R., Mosaliganti, K., Wenzel, P., Pan, T., de Bruin, A., Machiraju, R., Huang, K., Leone, G. and Saltz, J. (2007). Volume Rendering Phenotype Differences in Mouse Placenta Microscopy Data. Computing in Science & Engineering 9: 38-47.
  23. Wenzel, P. L., Wu, L., de Bruin, A., Chong, J. L., Chen, W. Y., Dureska, G., Sites, E., Pan, T., Sharma, A., Huang, K., Ridgway, R., Mosaliganti, K., Sharp, R., Machiraju, R., Saltz, J., Yamamoto, H., Cross, J. C., Robinson, M. L. and Leone, G. (2007). Rb is critical in a mammalian tissue stem cell population. Genes Dev 21(1): 85-97.
  24. Mosaliganti, K., Pan, T., Sharp, R., Ridgway, R., Iyengar, S., Gulacy, A., Wenzel, P., de Bruin, A., Machiraju, R., Huang, K., Leone, G. and Saltz, J. (2006). Registration and 3D visualization of large microscopy images. Proceedings of SPIE International Society of Optical Engineering 6144:61442V.
  25. Pan, T., Jewel, S., Catalyurek, U., Wenzel, P., Leone, G., Hastings, S., Oster, S., Langella, S., Kurc, T., Saltz, J. and Cowden, D. (2006). Virtual Microscopy: Distributed Image Storage, Retrieval, Analysis, and Visualization. In: Zomaya, A. Y. (ed). Parallel Computing for Bioinformatics and Computational Biology: Models, Enabling Technologies, and Case Studies: 737-763, Wiley.
  26. de Bruin, A., Wu, L., Saavedra, H. I., Wilson, P., Yang, Y., Rosol, T. J., Weinstein, M., Robinson, M. L. and Leone, G. (2003). Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proceedings of the National Academy of Sciences USA 100(11): 6546-6551.
  27. Wu, L., de Bruin, A., Saavedra, H. I., Starovic, M., Trimboli, A., Yang, Y., Opavska, J., Wilson, P., Thompson, J. C., Ostrowski, M. C., Rosol, T. J., Woollett, L. A., Weinstein, M., Cross, J. C., Robinson, M. L. and Leone, G. (2003). Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421(6926): 942-947.
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  29. MyNCBI Profile:
1 Protocol published
A Co-culture Assay to Determine Efficacy of TNF-α Suppression by Biomechanically Induced Human Bone Marrow Mesenchymal Stem Cells
Authors:  Miguel F. Diaz, Siobahn M. Evans, Scott D. Olson, Charles S. Cox Jr and Pamela L. Wenzel, date: 08/20/2017, view: 6210, Q&A: 0
The beneficial effects of mesenchymal stem cell (MSC)-based cellular therapies are believed to be mediated primarily by the ability of MSCs to suppress inflammation associated with chronic or acute injury, infection, autoimmunity, and ...
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