Nathalie Isorce 1 protocol

Marta Reverte Department of Biochemistry, University of Lausanne, 2015-2019
1 protocol

Remzi Onur Eren Department of Biochemistry, University of Lausanne, Switzerland, Switzerland,
1 protocol

Nicolas Fasel
  • Professor, Department of Biochemistry, University of Lausanne, Switzerland
Research focus
  • Microbiology
  • 3 Author merit


PhD in Molecular Biology, Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland, 1983

• Rossi, M., Castiglioni, P., Hartley, M. A., Eren, R. O., Prevel, F., Desponds, C., Utzschneider, D. T., Zehn, D., Cusi, M. G., Kuhlmann, F. M., Beverley, S. M., Ronet, C. and Fasel, N. (2017). Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis. Proc Natl Acad Sci U S A 114(19): 4987-4992.
• Castiglioni, P., Hartley, M. A., Rossi, M., Prevel, F., Desponds, C., Utzschneider, D. T., Eren, R. O., Zangger, H., Brunner, L., Collin, N., Zehn, D., Kuhlmann, F. M., Beverley, S. M., Fasel, N. and Ronet, C. (2017). Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid. PLoS Negl Trop Dis 11(1): e0005240.
• Kuhlmann, F. M., Robinson, J. I., Bluemling, G. R., Ronet, C., Fasel, N. and Beverley, S. M. (2017). Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor. Proc Natl Acad Sci U S A 114(5): E811-E819.
• Brettmann, E. A., Shaik, J. S., Zangger, H., Lye, L. F., Kuhlmann, F. M., Akopyants, N. S., Oschwald, D. M., Owens, K. L., Hickerson, S. M., Ronet, C., Fasel, N. and Beverley, S. M. (2016). Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response. Proc Natl Acad Sci U S A 113(43): 11998-12005.
• Eren, R. O., Reverte, M., Rossi, M., Hartley, M. A., Castiglioni, P., Prevel, F., Martin, R., Desponds, C., Lye, L. F., Drexler, S. K., Reith, W., Beverley, S. M., Ronet, C. and Fasel, N. (2016). Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence. Cell Host Microbe 20(3): 318-328.
• Hartley, M. A., Bourreau, E., Rossi, M., Castiglioni, P., Eren, R. O., Prevel, F., Couppie, P., Hickerson, S. M., Launois, P., Beverley, S. M., Ronet, C. and Fasel, N. (2016). Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A. PLoS Pathog 12(9): e1005852.
• Dias-Teixeira, K. L., Calegari-Silva, T. C., dos Santos, G. R., Vitorino Dos Santos, J., Lima, C., Medina, J. M., Aktas, B. H. and Lopes, U. G. (2016). The integrated endoplasmic reticulum stress response in Leishmania amazonensis macrophage infection: the role of X-box binding protein 1 transcription factor. FASEB J 30(4): 1557-1565.
• Genes, C. M., de Lucio, H., Gonzalez, V. M., Sanchez-Murcia, P. A., Rico, E., Gago, F., Fasel, N. and Jimenez-Ruiz, A. (2016). A functional BH3 domain in an aquaporin from Leishmania infantum. Cell Death Discov 2: 16043.
• Martin, R., Thome, M., Martinon, F. and Fasel, N. (2016). Raptor hunted by caspases. Cell Death and Diseases.
• Martin, R., Desponds, C., Eren, R. O., Quadroni, M., Thome, M. and Fasel, N. (2016). Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death. Cell Death and Discovery.
• Parmentier, L., Cusini, A., Muller, N., Zangger, H., Hartley, M. A., Desponds, C., Castiglioni, P., Dubach, P., Ronet, C., Beverley, S. M. and Fasel, N. (2016). Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus. Am J Trop Med Hyg 94(4): 840-843.
• Bourreau, E., Ginouves, M., Prevot, G., Hartley, M. A., Gangneux, J. P., Robert-Gangneux, F., Dufour, J., Sainte-Marie, D., Bertolotti, A., Pratlong, F., Martin, R., Schutz, F., Couppie, P., Fasel, N. and Ronet, C. (2016). Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse. J Infect Dis 213(1): 105-111.
• Casanova, M., Gonzalez, I. J., Sprissler, C., Zalila, H., Dacher, M., Basmaciyan, L., Spath, G. F., Azas, N. and Fasel, N. (2015). Implication of different domains of the Leishmania major metacaspase in cell death and autophagy. Cell Death Dis 6: e1933.
• Zangger, H., Hailu, A., Desponds, C., Lye, L. F., Akopyants, N. S., Dobson, D. E., Ronet, C., Ghalib, H., Beverley, S. M. and Fasel, N. (2014). Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response. PLoS Negl Trop Dis 8(4): e2836.
• Ives, A., Masina, S., Castiglioni, P., Prevel, F., Revaz-Breton, M., Hartley, M. A., Launois, P., Fasel, N. and Ronet, C. (2014). MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden. PLoS One 9(5): e96766.
• Ashok, D., Schuster, S., Ronet, C., Rosa, M., Mack, V., Lavanchy, C., Marraco, S. F., Fasel, N., Murphy, K. M., Tacchini-Cottier, F. and Acha-Orbea, H. (2014). Cross-presenting dendritic cells are required for control of Leishmania major infection. Eur J Immunol 44(5): 1422-1432.
• Weinkopff, T., Mariotto, A., Simon, G., Hauyon-La Torre, Y., Auderset, F., Schuster, S., Zangger, H., Fasel, N., Barral, A. and Tacchini-Cottier, F. (2013). Role of Toll-like receptor 9 signaling in experimental Leishmania braziliensis infection. Infect Immun 81(5): 1575-1584.
• Hartley, M. A., Kohl, K., Ronet, C. and Fasel, N. (2013). The therapeutic potential of immune cross-talk in leishmaniasis. Clin Microbiol Infect 19(2): 119-130.
• Zangger, H., Ronet, C., Desponds, C., Kuhlmann, F. M., Robinson, J., Hartley, M. A., Prevel, F., Castiglioni, P., Pratlong, F., Bastien, P., Muller, N., Parmentier, L., Saravia, N. G., Beverley, S. M. and Fasel, N. (2013). Detection of Leishmania RNA virus in Leishmania parasites. PLoS Negl Trop Dis 7(1): e2006.
• Hartley, M. A., Ronet, C., Zangger, H., Beverley, S. M. and Fasel, N. (2012). Leishmania RNA virus: when the host pays the toll. Front Cell Infect Microbiol 2: 99.
• Hartley, M. A., Ronet, C. and Fasel, N. (2012). Backseat drivers: the hidden influence of microbial viruses on disease. Curr Opin Microbiol 15(4): 538-545.
3 Protocols published
Viral Double-Stranded RNA Detection by DNase I and Nuclease S1 digestions in Leishmania parasites
Authors:  Nathalie Isorce and Nicolas Fasel, date: 05/05/2020, view: 491, Q&A: 0
Many RNA viruses are found in protozoan parasites. They can be responsible for more serious pathology or treatment failure. For the detection of viral double-stranded RNA (dsRNA), sequence-dependent and -independent methods are available, such as ...
Leishmania Parasite Quantification by Bioluminescence in Murine Models
Authors:  Marta Reverte and Nicolas Fasel, date: 11/20/2019, view: 1153, Q&A: 0
Leishmaniasis remains a major public health problem worldwide with a prevalence of 12 million, an incidence of 1 million persons, and 350 million people being at risk. Murine models have been largely used for studying the host-pathogen relationship ...
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