Kun‐Liang Guan Department of Pharmacology , University of California San Diego, La Jolla
2 protocols

Audrey W. Hong
  • Department of Pharmacology and Moores Cancer Center, University of California San Diego, USA
Research focus
  • Cancer biology
  • 1 Author merit


Bachelor, University of California Berkeley, United States, 2012

Current position

Ph.D student, Pharmacology department, University of California San Diego, United States


  1. Hong, A. W., Meng, Z., Yuan, H. X., Plouffe, S. W., Moon, S., Kim, W., Jho, E. H. and Guan, K. L. (2017). Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep 18(1): 72-86.
  2. Plouffe, S. W., Meng, Z., Lin, K. C., Lin, B., Hong, A. W., Chun, J. V. and Guan, K. L. (2016). Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell 64(5): 993-1008.
  3. Hong, A. W., Meng, Z. and Guan, K. L. (2016). The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol 13(6): 324-337.
  4. Meng, Z., Moroishi, T., Mottier-Pavie, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J. S., Lu, W., Lu, S., Flores, F., Yu, F. X., Halder, G. and Guan, K. L. (2015). MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun 6: 8357.
  5. Gong, R., Hong, A. W., Plouffe, S. W., Zhao, B., Liu, G., Yu, F. X., Xu, Y. and Guan, K. L. (2015). Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell Res 25(8): 985-988.
  6. Plouffe, S. W., Hong, A. W. and Guan, K. L. (2015). Disease implications of the Hippo/YAP pathway. Trends Mol Med 21(4): 212-222.
1 Protocol published
Non-radioactive LATS in vitro Kinase Assay
Authors:  Audrey W. Hong and Kun-Liang Guan, date: 07/20/2017, view: 9654, Q&A: 1
This protocol describes a method to directly measure LATS activity by an in vitro kinase assay using YAP as a substrate.
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