Karin Scharffetter-Kochanek Department of Dermatology and Allergic Diseases, University of Ulm, Germany
2 protocols

Anca Sindrilaru 1 protocol

Jana Muschhammer Department of Dermatology and Allergic Diseases, University of Ulm, Germany, Germany,
1 protocol

Juliane de Vries Department of Dermatology and Allergic Diseases, University of Ulm, Germany, Germany,
1 protocol

Dongsheng Jiang
  • Post-Doc, Comprehensive Pneumology Center, Helmholtz Zentrum München, Germany
Research focus
  • Stem cell
  • 2 Author merit


Ph.D., National University of Singapore, 2010


  1. Jiang, D., Muschhammer, J., Qi, Y., Kugler, A., de Vries, J. C., Saffarzadeh, M., Sindrilaru, A., Beken, S. V., Wlaschek, M., Kluth, M. A., Ganss, C., Frank, N. Y., Frank, M. H., Preissner, K. T. and Scharffetter-Kochanek, K. (2016). Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells. Stem Cells 34(9): 2393-2406.
  2. Makrantonaki, E., Jiang, D., Hossini, A. M., Nikolakis, G., Wlaschek, M., Scharffetter-Kochanek, K. and Zouboulis, C. C. (2016). Diabetes mellitus and the skin. Rev Endocr Metab Disord 17(3): 269-282.
  3. Jiang, D. and Scharffetter-Kochanek, K. (2015). Mesenchymal stem cells in wound repair, tissue homeostasis and aging. In: Geiger, H., Heinrich, J. and Florian, M. C. (Eds). Stem cell aging: mechanisms, consequences, rejuvenation. Springer, ISBN 978-3-7091-1231-1.
  4. Zhang, Y., Ying, J., Jiang, D., Chang, Z., Li, H., Zhang, G., Gong, S., Jiang, X. and Tao, J. (2015). Urotensin-II receptor stimulation of cardiac L-type Ca2+ channels requires the betagamma subunits of Gi/o-protein and phosphatidylinositol 3-kinase-dependent protein kinase C beta1 isoform. J Biol Chem 290(13): 8644-8655.
  5. Qi, Y., Jiang, D., Sindrilaru, A., Stegemann, A., Schatz, S., Treiber, N., Rojewski, M., Schrezenmeier, H., Vander Beken, S., Wlaschek, M., Bohm, M., Seitz, A., Scholz, N., Durselen, L., Brinckmann, J., Ignatius, A. and Scharffetter-Kochanek, K. (2014). TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds. J Invest Dermatol 134(2): 526-537.
  6. Tang, Q., Jiang, D., Harfuddin, Z., Cheng, K., Moh, M. C. and Schwarz, H. (2014). Regulation of myelopoiesis by CD137L signaling. Int Rev Immunol 33(6): 454-469.
  7. Saffarzadeh, M., Cabrera-Fuentes, H. A., Veit, F., Jiang, D., Scharffetter-Kochanek, K., Gille, C., Rooijakkers, S. H. M., Hartl, D. and Preissner, K. T. (2014). Characterization of rapid neutrophil extracellular trap formation and its cooperation with phagocytosis in human neutrophils. Discoveries 2: e19.
  8. Jiang, D., Qi, Y., Walker, N. G., Sindrilaru, A., Hainzl, A., Wlaschek, M., MacNeil, S. and Scharffetter-Kochanek, K. (2013). Adipose tissue derived mesenchymal stem cells delivered by a chemically defined carrier accelerate mouse acute cutaneous wound healing. Biomaterials 34: 2501-2515.
  9. Mukhametshina, R. T., Ruhs, A., Singh, I., Hasan, D., Contreras, A., Mehta, A., Nikam, V. S., Ahlbrecht, K., Carraro, G., Cabrera-Fuentes, H. A., Jiang, D., Voswinckel, R., Seeger, W., Bellusci, S., Scharffetter-Kochanek, K., Bagaeva, T. V., Preissner, K. T., Boettger, T., Braun, T., Kruger, M. and Barreto, G. (2013). Quantitative proteome analysis of alveolar type-II cells reveals a connection of integrin receptor subunits beta 2/6 and WNT signaling. J Proteome Res 12(12): 5598-5608.
  10. Tang, Q., Koh, L. K., Jiang, D. and Schwarz, H. (2013). CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging. Aging (Albany NY) 5(9): 643-652.
  11. Tang, Q., Jiang, D., Alonso, S., Pant, A., Martinez Gomez, J. M., Kemeny, D. M., Chen, L. and Schwarz, H. (2013). CD137 ligand signaling enhances myelopoiesis during infections. Eur J Immunol 43(6): 1555-1567.
  12. Zhang, Y., Jiang, D., Zhang, Y., Jiang, X., Wang, F. and Tao, J. (2012). Neuromedin U type 1 receptor stimulation of A-type K+ current requires the betagamma subunits of Go protein, protein kinase A, and extracellular signal-regulated kinase 1/2 (ERK1/2) in sensory neurons. J Biol Chem 287(22): 18562-18572.
  13. Zhang, Y., Zhang, J., Jiang, D., Zhang, D., Qian, Z., Liu, C. and Tao, J. (2012). Inhibition of T-type Ca(2)(+) channels by endostatin attenuates human glioblastoma cell proliferation and migration. Br J Pharmacol 166(4): 1247-1260.
  14. Zhang, L., Zhang, Y., Jiang, D., Reid, P. F., Jiang, X., Qin, Z. and Tao, J. (2012). Alpha-cobratoxin inhibits T-type calcium currents through muscarinic M4 receptor and Gomicron-protein betagamma subunits-dependent protein kinase A pathway in dorsal root ganglion neurons. Neuropharmacology 62(2): 1062-1072.
  15. Ong, S. M., Tan, Y. C., Beretta, O., Jiang, D., Yeap, W. H., Tai, J. J., Wong, W. C., Yang, H., Schwarz, H., Lim, K. H., Koh, P. K., Ling, K. L. and Wong, S. C. (2012). Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response. Eur J Immunol 42(1): 89-100.
  16. Jiang, D., Tang, Q. and Schwarz, H. (2011). Involvement of the cytokine receptor CD137 in murine hematopoiesis. Adv Exp Med Biol 691: 375-382.
  17. Liu, K., Jiang, D., Zhang, T., Tao, J., Shen, L. and Sun, X. (2011). Activation of growth hormone secretagogue type 1a receptor inhibits T-type Ca2+ channel currents through pertussis toxin-sensitive novel protein kinase C pathway in mouse spermatogenic cells. Cell Physiol Biochem 27(5): 613-624.
  18. Tang, Q., Jiang, D., Shao, Z., Martinez Gomez, J. M. and Schwarz, H. (2011). Species difference of CD137 ligand signaling in human and murine monocytes. PLoS One 6(1): e16129.
  19. Jiang, D. and Schwarz, H. (2010). Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein. PLoS One 5(12): e15565.
  20. Zhang, Y., Jiang, D., Zhang, J., Wang, F., Jiang, X. and Tao, J. (2010). Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons. Cell Signal 22(11): 1660-1668.
  21. Jiang, D., Chen, Y. and Schwarz, H. (2008). CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol 181(6): 3923-3932.
  22. Jiang, D., Yue, P. S., Drenkard, D. and Schwarz, H. (2008). Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Stem Cells 26(9): 2372-2381.

2 Protocols published
Mouse Model of Immune Complex-mediated Vasculitis in Dorsal Skin and Assessment of the Neutrophil-mediated Tissue Damage
Neutrophils are the most abundant leukocytes in the blood. In the recent decades, their crucial roles in host defense, immune regulation and tissue damage have been studied in a deeper dimension. In this protocol, we described a mouse model of ...
In vitro Demonstration and Quantification of Neutrophil Extracellular Trap Formation
Authors:  Dongsheng Jiang, Mona Saffarzadeh and Karin Scharffetter-Kochanek, date: 07/05/2017, view: 1955, Q&A: 0
In the recent decade, neutrophil extracellular traps (NETs) have been identified and confirmed as a new anti-microbial weapon of neutrophils. In this protocol, we describe easy methods to demonstrate NET formation by immunofluorescence staining of ...