Seong-Mi Choi Institute for BioMedical Convergence, Catholic Kwandong University-International St. Mary’s Hospital, Republic of Korea
1 protocol

Ji Yong Lee Institute for BioMedical Convergence, Catholic Kwandong University-International St. Mary’s Hospital, Republic of Korea
1 protocol

Han-Soo Kim
  • Department of Biomedical Sciences, College of Medical Convergence, Catholic Kwandong University, Republic of Korea
  • 1 Author merit

Education

Ph.D, Rutgers, the State University of New Jersey, USA, 1993

Current position

Associate Professor, Department of Biomedical Sciences, Catholic Kwandong University, Republic of Korea

Publications (since 2008)

  1. Yoo, J., Kim, H. S., Seo, J. J., Eom, J. H., Choi, S. M., Park, S., Kim, D. W. and Hwang, D. Y. (2016). Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke. Oncotarget 7(48): 79131-79140.
  2. Kim, H. S. (2016). Mesenchymal Stem Cells vs. Mesenchymal Stem Cell Secretome for Rheumatoid Arthritis Treatment. JSM Arthritis 1(1): 1001.
  3. Lee, J. Y., Kim, E., Choi, S. M., Kim, D. W., Kim, K. P., Lee, I. and Kim, H. S. (2016). Microvesicles from brain-extract-treated mesenchymal stem cells improve neurological functions in a rat model of ischemic stroke. Sci Rep 6: 33038.
  4. Kim, I. K., Kim, S. H., Choi, S. M., Youn, B. S. and Kim, H. S. (2016). Extracellular Vesicles as Drug Delivery Vehicles for Rheumatoid Arthritis. Curr Stem Cell Res Ther 11(4): 329-342.
  5. Heo, J. S., Choi, Y., Kim, H. S. and Kim, H. O. (2016). Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med 37(1): 115-125.
  6. Sung, K. H., Kim, S. H., Youn, B. S. and Kim, H. S. (2015). Globular adiponectin induced leukocytosis and mobilizes hematopoietic progenitor cells in mice. Tissue Eng Reg Med 12(6):449-456.
  7. Kim, S. H., Choi, S. M., Youn, B. S. and Kim, H. S. (2015). Adiponectin inhibits mouse mammary tumor growth and reduced tumor-induced hematopoiesis. Tissue Eng Reg Med 12(5):324-330.
  8. Kim, S. W., Choi, S. M., Choo, Y. S., Kim, I. K., Song, B. W. and Kim, H. S. (2015). Flt3 ligand induces monocyte proliferation and enhances the function of monocyte-derived dendritic cells in vitro. J Cell Physiol 230(8): 1740-1749.
  9. Oh, J., Kim, J. Y., Kim, H. S., Oh, J. C., Cheon, Y. H., Park, J., Yoon, K. H., Lee, M. S. and Youn, B. S. (2015). Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor kappaB (RANK)-dependent formation of multinucleated osteoclasts. J Biol Chem 290(4): 2042-2052.
  10. Lee, D. R., Yoo, J. E., Lee, J. S., Park, S., Lee, J., Park, C. Y., Ji, E., Kim, H. S., Hwang, D. Y., Kim, D. S. and Kim, D. W. (2015). PSA-NCAM-negative neural crest cells emerging during neural induction of pluripotent stem cells cause mesodermal tumors and unwanted grafts. Stem Cell Reports 4(5): 821-834.
  11. Kim, M. H., Guo, L., Kim, H. S. and Kim, S. W. (2014). Characteristics of circulating CD31(+) cells from patients with coronary artery disease. J Cell Mol Med 18(11): 2321-2330.
  12. Li, Y., Zhang, Z., Kim, H. S., Han, S. and Kim, S. W. (2014). CD31(+) cell transplantation promotes recovery from peripheral neuropathy. Mol Cell Neurosci 62: 60-67.
  13. Lee, S. H., Park, S., Kim, H. S. and Jung, B. H. (2014). Metabolomic approaches to the normal aging process. Metabolomics 10: 1268-1292.
  14. Kim, H. S., Choi, S. M., Yang, W., Kim, D. S., Lee, D. R., Cho, S. R. and Kim, D. W. (2014). PSA-NCAM(+) neural precursor cells from human embryonic stem cells promote neural tissue integrity and behavioral performance in a rat stroke model. Stem Cell Rev 10(6): 761-771.
  15. Jin, H., Kim, H. S., Kim, S. and Kim, H. O. (2014). Erythropoietic potential of CD34+ hematopoietic stem cells from human cord blood and G-CSF-mobilized peripheral blood. Biomed Res Int 2014: 435215.
  16. Kim, H. S., Kang, D., Moon, M. H. and Kim, H. J. (2014). Identification of pancreatic cancer-associated tumor antigen from HSP-enriched tumor lysate-pulsed human dendritic cells. Yonsei Med J 55(4): 1014-1027.
  17. You, J., Park, T., Kim, J., Heo, J. S., Kim, H. S., Kim, H. O. and Kim, E. (2014). Highly fluorescent conjugated polyelectrolyte for protein sensing and cell-compatible chemosensing applications. ACS Appl Mater Interfaces 6(5): 3305-3311.
  18. You, J., Heo, J. S., Kim, J., Park, T., Kim, B., Kim, H. S., Choi, Y., Kim, H. O. and Kim, E. (2013). Noninvasive photodetachment of stem cells on tunable conductive polymer nano thin films: selective harvesting and preserved differentiation capacity. ACS Nano 7(5): 4119-4128.
  19. Kim, H. O., Choi, S. M. and Kim, H. S. (2013). Mesenchymal stem cell-derived secretome and microvesicles as a cell-free therapeutics for neurodegenerative disorders. Tissue Eng Reg Med 10(3): 93-101.
  20. Heo, J. S., Choi, S. M., Kim, H. O., Kim, E. H., You, J., Park, T., Kim, E. and Kim, H. S. (2013). Neural transdifferentiation of human bone marrow mesenchymal stem cells on hydrophobic polymer-modified surface and therapeutic effects in an animal model of ischemic stroke. Neuroscience 238: 305-318.
  21. Sohn, H. S., Heo, J. S., Kim, H. S., Choi, Y. and Kim, H. O. (2013). Duration of in vitro storage affects the key stem cell features of human bone marrow-derived mesenchymal stromal cells for clinical transplantation. Cytotherapy 15(4): 460-466.
  22. Yoo, J., Kim, H. S. and Hwang, D. Y. (2013). Stem cells as promising therapeutic options for neurological disorders. J Cell Biochem 114(4): 743-753.
  23. Park, C. Y., Kim, H. S., Jang, J., Lee, H., Lee, J. S., Yoo, J. E., Lee, D. R. and Kim, D. W. (2013). ABCD2 is a direct target of beta-catenin and TCF-4: implications for X-linked adrenoleukodystrophy therapy. PLoS One 8(2): e56242.
  24. Jang, J., Kim, H. S., Kang, J. W. and Kang, H. C. (2013). The genetically modified polysialylated form of neural cell adhesion molecule-positive cells for potential treatment of X-linked adrenoleukodystrophy. Yonsei Med J 54(1): 246-252.
  25. Lee, P. H., Lee, J. E., Kim, H. S., Song, S. K., Lee, H. S., Nam, H. S., Cheong, J. W., Jeong, Y., Park, H. J., Kim, D. J., Nam, C. M., Lee, J. D., Kim, H. O. and Sohn, Y. H. (2012). A randomized trial of mesenchymal stem cells in multiple system atrophy. Ann Neurol 72(1): 32-40.
  26. Jang, J., Yoo, J. E., Lee, J. A., Lee, D. R., Kim, J. Y., Huh, Y. J., Kim, D. S., Park, C. Y., Hwang, D. Y., Kim, H. S., Kang, H. C. and Kim, D. W. (2012). Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery. Exp Mol Med 44(3): 202-213.
  27. Jung, M. Y., Kim, H. S., Hong, H. J., Youn, B. S. and Kim, T. S. (2012). Adiponectin induces dendritic cell activation via PLCgamma/JNK/NF-kappaB pathways, leading to Th1 and Th17 polarization. J Immunol 188(6): 2592-2601.
  28. Kim, H. S., Choi, D. Y., Yun, S. J., Choi, S. M., Kang, J. W., Jung, J. W., Hwang, D., Kim, K. P. and Kim, D. W. (2012). Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J Proteome Res 11(2): 839-849.
  29. Kim, D. S., Lee, D. R., Kim, H. S., Yoo, J. E., Jung, S. J., Lim, B. Y., Jang, J., Kang, H. C., You, S., Hwang, D. Y., Leem, J. W., Nam, T. S., Cho, S. R. and Kim, D. W. (2012). Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes. PLoS One 7(7): e39715.
  30. Kim, D. S., Kim, D. H., Goo, B., Cho, Y. H., Park, J. M., Lee, T. H., Kim, H. O., Kim, H. S., Lee, H., Lee, J. D., Byamba, D., Je, J. H. and Lee, M. G. (2011). Immunotherapy of malignant melanoma with tumor lysate-pulsed autologous monocyte-derived dendritic cells. Yonsei Med J 52(6): 990-998.
  31. Kim, H. O., Kim, H. S., Youn, J. C., Shin, E. C. and Park, S. (2011). Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays. J Transl Med 9: 113.
  32. You, J., Yoshida, A., Heo, J. S., Kim, H. S., Kim, H. O., Tamada, K. and Kim, E. (2011). Protein coverage on polymer nanolayers leading to mesenchymal stem cell patterning. Phys Chem Chem Phys 13(39): 17625-17632.
  33. Lee, H. J., Kim, H. S., Kim, H. O. and Koh, W. G. (2011). Micropatterns of double-layered nanofiber scaffolds with dual functions of cell patterning and metabolite detection. Lab Chip 11(17): 2849-2857.
  34. Jang, J., Kang, H. C., Kim, H. S., Kim, J. Y., Huh, Y. J., Kim, D. S., Yoo, J. E., Lee, J. A., Lim, B., Lee, J., Yoon, T. M., Park, I. H., Hwang, D. Y., Daley, G. Q. and Kim, D. W. (2011). Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients. Ann Neurol 70(3): 402-409.
  35. Lee, P. H., Kim, H. S., Lee, J. E., Choi, Y., Hong, J. Y., Nam, H. S., Sohn, Y. H. and Kim, H. O. (2011). Comparison of endothelial progenitor cells in Parkinson's disease patients treated with levodopa and levodopa/COMT inhibitor. PLoS One 6(6): e21536.
  36. Park, S., Kim, H. O. and Kim, H. S. (2011). Aging-associated decline in innate immunity and therapeutic strategies to counteract it. Tissue Engineering and Regenerative Medicine 8(2): 124-132.
  37. Kim, S., Kim, H. S., Lee, E. and Kim, H. O. (2011). In vivo hepatic differentiation potential of human cord blood-derived mesenchymal stem cells. Int J Mol Med 27(5): 701-706.
  38. Kim, S., Heo, J. S., Kim, H. S. and Kim, H. O. (2010). Isolation of mesenchymal stem cells from the mononuclear cells remaining in the bone marrow processing kit. Korean J. Blood Transfus. 21: 280-288.
  39. Kim, H. S., Heo, J. S., You, J., Park, T., Choi, Y., Kim, E., Kim, H. O. (2010). Fast and efficient isolation of mouse bone marrow-derived mesenchymal stem cells by using a biocompatible polymer. Tissue Engineering and Regenerative Medicine 7(4): 443-451.
  40. Lee, J., Kim, H. O., Song, S. Y. and Kim, H. S. (2010). Enhanced neovascularization by simultaneous transplantation of peripheral blood CD34+ hematopoietic stem cells and CD14+ monocytes. Tissue Eng. Reg. Med. 7(2): 223-229.
  41. Kim, H. J., Kim, H. O., Lee, K., Baek, E. J. and Kim, H. S. (2010). Two-step maturation of immature DCs with proinflammatory cytokine cocktail and poly(I:C) enhances migratory and T cell stimulatory capacity. Vaccine 28(16): 2877-2886.
  42. Baek, E. J., Kim, H. S., Kim, J. H., Kim, N. J. and Kim, H. O. (2009). Stroma-free mass production of clinical-grade red blood cells (RBCs) by using poloxamer 188 as an RBC survival enhancer. Transfusion 49(11): 2285-2295.
  43. You, J., Heo, J. S., Lee, J., Kim, H. S., Kim, H. O. and Kim, E. (2009). A fluorescent polymer for patterning of mesenchymal stem cells. Macromolecules 42: 3326–3332.
  44. Lee, Y., Kim, S., Lee, S. T., Kim, H. S., Baek, E. J., Kim, H. J., Lee, M. and Kim, H. O. (2009). Analysis of characteristics of mononuclear cells remaining in the leukoreduction system chamber of Trima Accel and their differentiation into dendritic cells. Korean J Lab Med 29(4): 353-360.
  45. Kim, S., Kim, H. O., Kim, H. J., Lee, K. and Kim, H. S. (2008). Generation of functionally mature dendritic cells from elutriated monocytes using polyinosinic : polycytidylic acid and soluble CD40 ligand for clinical application. Clin Exp Immunol 154(3): 365-374.
  46. Baek, E. J., Kim, H. S., Kim, S., Jin, H., Choi, T. Y. and Kim, H. O. (2008). In vitro clinical-grade generation of red blood cells from human umbilical cord blood CD34+ cells. Transfusion 48(10): 2235-2245.
  47. Lee, S. K., Kim, S., Kim, H. S., Baek, E. J., Jin, H. L., Kim, J. and Kim, H. O. (2008). Post-thaw viable CD34+ cell counts are a valuable predictor of hematopoietic stem cell engraftment. Vox Sang 94: 146-152.
1 Protocol published
Microvesicle Isolation from Rat Brain Extract Treated Human Mesenchymal Stem Cells
Authors:  Ji Yong Lee, Seong-Mi Choi and Han-Soo Kim, date: 07/05/2017, view: 3733, Q&A: 0
Microvesicle (MVs) are submicron-sized membranous vesicles that are either actively released from cells via secretory compartments or shed from cell surface membranes. MVs are generated by many cell types and serve as vehicles that transfer ...
您可以切换至中文站点,以获得适用于中国用户的内容 中文站点
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.