Rafael Maldonado Pharmacology Pompeu Fabra University
4 protocols

Andrés Ozaita 1 protocol

Giovanni Marsicano INSERM U1215 NEUROCENTRE MAGENDIE, UNIVERSITE DE BORDEAUX, FRANCE
5 protocols

Alexandra Gros CNES - University of Bordeaux (IMN)
7 protocols

Andrew Eagle Michigan State University
6 protocols

Bo Liang National Institute on Drug Abuse
1 protocol

Edgar Soria-Gomez Faculty of Medicine and Nursery, University of the Basque Country
26 protocols

Editor
Arnau Busquets-Garcia
  • Junior researcher, IMIM, Parc de Recerca Biomedica, 2019-
Research focus
  • Neuroscience
  • 3 Author merit

Education

PhD, University Pompeu Fabra, 2009

Publications

1. Busquets-Garcia, A., Soria-Gomez, E., Redon, B., Mackenbach, Y., Vallee, M., Chaouloff, F., Varilh, M., Ferreira, G., Piazza, P. V. and Marsicano, G. (2017). Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice. Mol Psychiatry.
2. Saravia, R., Flores, A., Plaza-Zabala, A., Busquets-Garcia, A., Pastor, A., de la Torre, R., Di Marzo, V., Marsicano, G., Ozaita, A., Maldonado, R. and Berrendero, F. (2017). CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. Biol Psychiatry 81(7): 625-634.
3. Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A. C., Delamarre, A., Cannich, A., Vincent, P., Varilh, M., Robin, L. M., Terral, G., Garcia-Fernandez, M. D., Colavita, M., Mazier, W., Drago, F., Puente, N., Reguero, L., Elezgarai, I., Dupuy, J. W., Cota, D., Lopez-Rodriguez, M. L., Barreda-Gomez, G., Massa, F., Grandes, P., Benard, G. and Marsicano, G. (2016). A cannabinoid link between mitochondria and memory. Nature 539(7630): 555-559.
4. Gomis-Gonzalez, M., Busquets-Garcia, A., Matute, C., Maldonado, R., Mato, S. and Ozaita, A. (2016). Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model. Genes (Basel) 7(9).
5. Ramos-Fernandez, E., Tajes, M., Ill-Raga, G., Vargas, L., Busquets-Garcia, A., Bosch-Morato, M., Guivernau, B., Valls-Comamala, V., Gomis, M., Grau, C., Fandos, C., Rosen, M. D., Rabinowitz, M. H., Inestrosa, N., Maldonado, R., Altafaj, X., Ozaita, A., Alvarez, A., Vicente, R., Valverde, M. A. and Munoz, F. J. (2016). Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2alpha kinase in cortical neurons. Oncotarget 7(37): 58876-58892.
6. Busquets-Garcia, A., Gomis-Gonzalez, M., Srivastava, R. K., Cutando, L., Ortega-Alvaro, A., Ruehle, S., Remmers, F., Bindila, L., Bellocchio, L., Marsicano, G., Lutz, B., Maldonado, R. and Ozaita, A. (2016). Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci U S A 113(35): 9904-9909.
7. Busquets Garcia, A., Soria-Gomez, E., Bellocchio, L. and Marsicano, G. (2016). Cannabinoid receptor type-1: breaking the dogmas. F1000Res 5.
8. Busquets-Garcia, A., Desprez, T., Metna-Laurent, M., Bellocchio, L., Marsicano, G. and Soria-Gomez, E. (2015). Dissecting the cannabinergic control of behavior: The where matters. Bioessays 37(11): 1215-1225.
9. Soria-Gomez, E., Busquets-Garcia, A., Hu, F., Mehidi, A., Cannich, A., Roux, L., Louit, I., Alonso, L., Wiesner, T., Georges, F., Verrier, D., Vincent, P., Ferreira, G., Luo, M. and Marsicano, G. (2015). Habenular CB1 Receptors Control the Expression of Aversive Memories. Neuron 88(2): 306-313.
10. Ill-Raga, G., Tajes, M., Busquets-Garcia, A., Ramos-Fernandez, E., Vargas, L. M., Bosch-Morato, M., Guivernau, B., Valls-Comamala, V., Eraso-Pichot, A., Guix, F. X., Fandos, C., Rosen, M. D., Rabinowitz, M. H., Maldonado, R., Alvarez, A. R., Ozaita, A. and Munoz, F. J. (2015). Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2alpha Kinase HRI Induces Synaptogenesis. Antioxid Redox Signal 22(15): 1295-1307.
11. Busquets-Garcia, A., Maldonado, R. and Ozaita, A. (2014). New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model. Int J Biochem Cell Biol 53: 121-126.
12. Busquets-Garcia, A., Gomis-Gonzalez, M., Guegan, T., Agustin-Pavon, C., Pastor, A., Mato, S., Perez-Samartin, A., Matute, C., de la Torre, R., Dierssen, M., Maldonado, R. and Ozaita, A. (2013). Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nat Med 19(5): 603-607.
13. Garcia-Gutierrez, M. S., Ortega-Alvaro, A., Busquets-Garcia, A., Perez-Ortiz, J. M., Caltana, L., Ricatti, M. J., Brusco, A., Maldonado, R. and Manzanares, J. (2013). Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors. Neuropharmacology 73: 388-396.
14. Cutando, L., Busquets-Garcia, A., Puighermanal, E., Gomis-Gonzalez, M., Delgado-Garcia, J. M., Gruart, A., Maldonado, R. and Ozaita, A. (2013). Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure. J Clin Invest 123(7): 2816-2831.
15. Puighermanal, E., Busquets-Garcia, A., Gomis-Gonzalez, M., Marsicano, G., Maldonado, R. and Ozaita, A. (2013). Dissociation of the pharmacological effects of THC by mTOR blockade. Neuropsychopharmacology 38(7): 1334-1343.
16. Puighermanal, E., Busquets-Garcia, A., Maldonado, R. and Ozaita, A. (2012). Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philos Trans R Soc Lond B Biol Sci 367(1607): 3254-3263.
17. Busquets-Garcia, A., Puighermanal, E., Pastor, A., de la Torre, R., Maldonado, R. and Ozaita, A. (2011). Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol Psychiatry 70(5): 479-486.
18. Puighermanal, E., Marsicano, G., Busquets-Garcia, A., Lutz, B., Maldonado, R. and Ozaita, A. (2009). Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci 12(9): 1152-1158.
19. Comas, D., Schmid, H., Braeuer, S., Flaiz, C., Busquets, A., Calafell, F., Bertranpetit, J., Scheil, H. G., Huckenbeck, W., Efremovska, L. and Schmidt, H. (2004). Alu insertion polymorphisms in the Balkans and the origins of the Aromuns. Ann Hum Genet 68(Pt 2): 120-127.
3 Protocols published
An Alternative Maze to Assess Novel Object Recognition in Mice
The novel object recognition (NOR) task is a behavioral test commonly used to evaluate episodic-like declarative memory and it relies on the innate tendency of rodents to explore novelty. Here we present a maze used to evaluate NOR memory in mice ...
Assessing Prepulse Inhibition of Startle in Mice
Authors:  Christina Ioannidou, Giovanni Marsicano and Arnau Busquets-Garcia, date: 04/05/2018, view: 8088, Q&A: 0
Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce ‘core’ symptoms of complex human disorders such as schizophrenia. Despite ...
4 Protocols reviewed
Assessing Classical Olfactory Fear Conditioning by Behavioral Freezing in Mice
Authors:  Jordan M. Ross and Max L. Fletcher, date: 09/20/2018, view: 3126, Q&A: 0
Classical fear conditioning typically involves pairing a discrete cue with a foot shock. Quantifying behavioral freezing to the learned cue is a crucial assay for neuroscience studies focused on learning and memory. Many paradigms utilize discrete ...
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Evaluating Working Memory on a T-maze in Male Rats
Authors:  Ahmed M. Hussein, Mekite Bezu and Volker Korz, date: 07/20/2018, view: 6692, Q&A: 0
Working memory is short-term memory, so temporal improvement does not reflect the consolidation of a memory trace, rather the functionality of the underlying neuronal circuits and molecular signaling cascades. The administration of drugs–either ...
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14 Protocols edited
Nestlet Shredding and Nest Building Tests to Assess Features of Psychiatric Disorders in Mice
Authors:  Fabian Dorninger, Gerhard Zeitler and Johannes Berger, date: 12/20/2020, view: 607, Q&A: 0

Mimicking the various facets of human psychiatric and neurodevelopmental disorders in animal models is a challenging task. Nevertheless, mice have emerged as a widely used model system to study pathophysiology and treatment strategies for these

...
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Visual-looming Shadow Task with in-vivo Calcium Activity Monitoring to Assess Defensive Behaviors in Mice
There has been a clear movement in recent years towards the adoption of more naturalistic experimental regimes for the study of behavior and its underlying neural architecture. Here we provide a protocol that allows experimenters working with mice, ...
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