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Coauthors
Adam Richman Center for Cancer and Immunology Research, Children’s National Medical Center, USA
1 protocol

Yulong Fu Center for Cancer and Immunology Research, Children’s National Medical Center, USA
1 protocol

Junyi Zhu University of California, Los Angeles
1 protocol

Zhe Han
  • Center for Cancer and Immunology Research, Children’s National Medical Center, USA
  • 1 Author merit

Education

Ph.D, University of Michigan, USA, 1996

Current position

Associate Professor, Genetic Medicine, Children's National Medical Center, USA

Assistant Professor, Medicine, University of Michigan, USA

Postdoc / Instructor, Molecular Biology, UT Southwestern, USA

Publications

  1. Zhu, J. Y., Heidersbach, A., Kathiriya, I. S., Garay, B. I., Ivey, K. N., Srivastava, D., Han, Z. and King, I. N. (2017). The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1. Development 144(5): 866-875.
  2. Fu, Y., Zhu, J. Y., Zhang, F., Richman, A., Zhao, Z. and Han, Z. (2017). Comprehensive functional analysis of Rab GTPases in Drosophila nephrocytes. Cell Tissue Res 368(3): 615-627.
  3. Fu, Y., Zhu, J. Y., Richman, A., Zhao, Z., Zhang, F., Ray, P. E. and Han, Z. (2017). A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. Hum Mol Genet 26(4): 768-780.
  4. Zhu, J. Y., Fu, Y., Nettleton, M., Richman, A. and Han, Z. (2017). High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. Elife 6.
  5. Zhu, S., Han, Z., Luo, Y., Chen, Y., Zeng, Q., Wu, X. and Yuan, W. (2017). Molecular mechanisms of heart failure: insights from Drosophila. Heart Fail Rev 22(1): 91-98.
  6. Fu, Y., Zhu, J. Y., Richman, A., Zhang, Y., Xie, X., Das, J. R., Li, J., Ray, P. E. and Han, Z. (2017). APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death. J Am Soc Nephrol 28(4): 1106-1116.
  7. Li, J., Das, J. R., Tang, P., Han, Z., Jaiswal, J. K. and Ray, P. E. (2017). Transmembrane TNF-alpha Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy. J Am Soc Nephrol 28(3): 862-875.
  8. Jiang, Z., Li, F., Wan, Y., Han, Z., Yuan, W., Cao, L., Deng, Y., Peng, X., Chen, F., Fan, X., Liu, X., Dai, G., Wang, Y., Zeng, Q., Shi, Y., Zhou, Z., Chen, Y., Xu, W., Luo, S., Chen, S., Ye, X., Mo, X., Wu, X. and Li, Y. (2016). LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity. Curr Mol Med 16(6): 582-590.
  9. Patel, M. V., Zhu, J. Y., Jiang, Z., Richman, A., VanBerkum, M. F. and Han, Z. (2016). Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning. Dev Biol 414(1): 100-107.
  10. Chen, Z., Zhu, J. Y., Fu, Y., Richman, A. and Han, Z. (2016). Wnt4 is required for ostia development in the Drosophila heart. Dev Biol 413(2): 188-198.
  11. Fulga, T. A., McNeill, E. M., Binari, R., Yelick, J., Blanche, A., Booker, M., Steinkraus, B. R., Schnall-Levin, M., Zhao, Y., DeLuca, T., Bejarano, F., Han, Z., Lai, E. C., Wall, D. P., Perrimon, N. and Van Vactor, D. (2015). A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs. Nat Commun 6: 7279.
  12. Gee, H. Y., Zhang, F., Ashraf, S., Kohl, S., Sadowski, C. E., Vega-Warner, V., Zhou, W., Lovric, S., Fang, H., Nettleton, M., Zhu, J. Y., Hoefele, J., Weber, L. T., Podracka, L., Boor, A., Fehrenbach, H., Innis, J. W., Washburn, J., Levy, S., Lifton, R. P., Otto, E. A., Han, Z. and Hildebrandt, F. (2015). KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. J Clin Invest 125(6): 2375-2384.
  13. Ashraf, S., Gee, H. Y., Woerner, S., Xie, L. X., Vega-Warner, V., Lovric, S., Fang, H., Song, X., Cattran, D. C., Avila-Casado, C., Paterson, A. D., Nitschke, P., Bole-Feysot, C., Cochat, P., Esteve-Rudd, J., Haberberger, B., Allen, S. J., Zhou, W., Airik, R., Otto, E. A., Barua, M., Al-Hamed, M. H., Kari, J. A., Evans, J., Bierzynska, A., Saleem, M. A., Bockenhauer, D., Kleta, R., El Desoky, S., Hacihamdioglu, D. O., Gok, F., Washburn, J., Wiggins, R. C., Choi, M., Lifton, R. P., Levy, S., Han, Z., Salviati, L., Prokisch, H., Williams, D. S., Pollak, M., Clarke, C. F., Pei, Y., Antignac, C. and Hildebrandt, F. (2013). ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. J Clin Invest 123(12): 5179-5189.
  14. Gee, H. Y., Saisawat, P., Ashraf, S., Hurd, T. W., Vega-Warner, V., Fang, H., Beck, B. B., Gribouval, O., Zhou, W., Diaz, K. A., Natarajan, S., Wiggins, R. C., Lovric, S., Chernin, G., Schoeb, D. S., Ovunc, B., Frishberg, Y., Soliman, N. A., Fathy, H. M., Goebel, H., Hoefele, J., Weber, L. T., Innis, J. W., Faul, C., Han, Z., Washburn, J., Antignac, C., Levy, S., Otto, E. A. and Hildebrandt, F. (2013). ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. J Clin Invest 123(8): 3243-3253.
  15. Zhang, F., Zhao, Y., Chao, Y., Muir, K. and Han, Z. (2013). Cubilin and amnionless mediate protein reabsorption in Drosophila nephrocytes. J Am Soc Nephrol 24(2): 209-216.
  16. Zhang, F., Zhao, Y. and Han, Z. (2013). An in vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes. J Am Soc Nephrol 24(2): 191-197.
  17. Chen, Z., Liang, S., Zhao, Y. and Han, Z. (2012). miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development. Development 139(19): 3543-3552.
  18. Yi, P., Johnson, A. N., Han, Z., Wu, J. and Olson, E. N. (2008). Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Dev Cell 15(5): 704-713.
  19. Elalayli, M., Hall, J. D., Fakhouri, M., Neiswender, H., Ellison, T. T., Han, Z., Roon, P. and LeMosy, E. K. (2008). Palisade is required in the Drosophila ovary for assembly and function of the protective vitelline membrane. Dev Biol 319(2): 359-369.
  20. Liu, J., Qian, L., Han, Z., Wu, X. and Bodmer, R. (2008). Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. Dev Biol 313(2): 876-886.
  21. Liotta, D., Han, J., Elgar, S., Garvey, C., Han, Z. and Taylor, M. V. (2007). The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila. Curr Biol 17(16): 1409-1413.
  22. Yi, P., Han, Z., Li, X. and Olson, E. N. (2006). The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science 313(5791): 1301-1303.
  23. Han, Z., Yi, P., Li, X. and Olson, E. N. (2006). Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis. Development 133(6): 1175-1182.
  24. Kwon, C., Han, Z., Olson, E. N. and Srivastava, D. (2005). MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A 102(52): 18986-18991.
  25. Fujioka, M., Wessells, R. J., Han, Z., Liu, J., Fitzgerald, K., Yusibova, G. L., Zamora, M., Ruiz-Lozano, P., Bodmer, R. and Jaynes, J. B. (2005). Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan. Circ Res 97(11): 1108-1114.
  26. Han, Z. and Olson, E. N. (2005). Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis. Development 132(15): 3525-3536.
  27. Han, Z., Li, X., Wu, J. and Olson, E. N. (2004). A myocardin-related transcription factor regulates activity of serum response factor in Drosophila. Proc Natl Acad Sci U S A 101(34): 12567-12572.
  28. Han, Z. and Bodmer, R. (2003). Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130(13): 3039-3051.
  29. Han, Z. (2002). Genetic control of cardiac cell type specification in Drosophila. Dissertation.
  30. Han, Z., Fujioka, M., Su, M., Liu, M., Jaynes, J. B. and Bodmer, R. (2002). Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm. Dev Biol 252(2): 225-240.
1 Protocol published
Validating Candidate Congenital Heart Disease Genes in Drosophila
Authors:  Jun-yi Zhu, Yulong Fu, Adam Richman and Zhe Han, date: 06/20/2017, view: 1878, Q&A: 0
Genomic sequencing efforts can implicate large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system to validate candidate gene association with pathology is therefore ...