Lena Kjellén Department of Medical Biochemistry and Microbiology, Uppsala University,, Sverige
1 protocol

Tabea Dierker
  • Uppsala University
Research focus
  • Biochemistry
  • 1 Author merit


Dr. rer. nat. (PhD), University of Münster, Germany, 2009

Current position

Postdoc, Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden


  1. Dierker, T., Shao, C., Haitina, T., Zaia, J., Hinas, A. and Kjellén, L. (2016). Nematodes join the family of chondroitin sulfate producing organisms: Identification of an active chondroitin sulfotransferase in the nematode Caenorhabditis elegans. Sci Rep 6: 34662.
  2. Deligny, A., Dierke,r T., Dagälv, A., Lundequist, A., Eriksson, I., Nairn, A. V., Moremen, K. W., Merry, C. L. R. and Kjellén, L. (2016).  NDST2 (N-­‐deacetylase/N-­‐sulfotransferase-­‐2) Regulates Heparan Sulfate Chain Length. J Biol Chem 291(36): 18600-07.
  3. Dierker, T., Bachvarova, V., Krause, Y., Li, J. P., Kjellen, L., Seidler, D. G. and Vortkamp, A. (2016). Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones. Matrix Biol 49: 82-92.
  4. Habicher, J., Haitina, T., Eriksson, I., Holmborn, K., Dierker, T., Ahlberg, P. E. and Ledin, J. (2015). Chondroitin / dermatan sulfate modification enzymes in zebrafish development. PLoS One 10(3): e0121957.
  5. Kiselova, N., Dierker, T., Spillmann, D. and Ramstrom, M. (2014). An automated mass spectrometry-based screening method for analysis of sulfated glycosaminoglycans. Biochem Biophys Res Commun 450(1): 598-603.
  6. Farshi, P., Ohlig, S., Pickhinke, U., Hoing, S., Jochmann, K., Lawrence, R., Dreier, R., Dierker, T. and Grobe, K. (2011). Dual roles of the Cardin-Weintraub motif in multimeric Sonic hedgehog. J Biol Chem 286(26): 23608-23619.
  7. Ohlig, S., Farshi, P., Pickhinke, U., van den Boom, J., Höing, S., Jakuschev, S., Hoffmann, D., Dreier, R., Schöler, H. R., Dierker, T., Bordych, C. and Grobe, K. (2011). Sonic hedgehog shedding in functional activation of the solubilized morphogen. Dev Cell 20(6): 764-­74.
  8. Dierker, T., Dreier, R., Migone, M., Hamer, S. and Grobe, K. (2009). Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers. J Biol Chem 284(47): 32562-32571.
  9. Dierker, T., Dreier, R., Petersen, A., Bordych, C. and Grobe, K. (2009). Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells. J Biol Chem 284(12): 8013-8022.
  10. Dierker, T. (2016). When structure matters – how heparan sulfate epimerization affects animal development. Musculoskeletal Regeneration 2: e1091.
  11. Dagälv, A., Lundequist, A., Filipek-Górniok, B., Dierker, T., Eriksson, I. and Kjellén, L. (2015). Heparan sulfate structure: methods to study N-sulfation and NDST action. Methods Mol Biol 1229: 189-200.
1 Protocol published
Separation and Purification of Glycosaminoglycans (GAGs) from Caenorhabditis elegans
Authors:  Tabea Dierker and Lena Kjellén, date: 08/05/2017, view: 9684, Q&A: 1
The nematode Caenorhabditis elegans is a popular model organism for studies of developmental biology, neurology, ageing and other fields of basic research. Because many developmental processes are regulated by glycosaminoglyans (GAGs) on ...
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