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Jing Ai
  • Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), College of Pharmacy of Harbin Medical University, Harbin Medical University, China, China,
  • 1 Author merit

Education

PhD, Harbin Medical University, China, 2004

Current position

Professor, Pharmacology, Harbin Medical University, China

Publications

  1. Zhou, J., Lei, B., Li, H., Zhu, L., Wang, L., Tao, H., Mei, S. and Li, F. (2017). MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells. Cell Death Dis 8(2): e2597.
  2. Yan, Y., Cheng, L., Chen, X., Wang, Q., Duan, M., Ma, J., Zhao, L., Jiang, X. and Ai, J. (2017). Estrogen deficiency is associated with hippocampal morphological remodeling of early postmenopausal mice. Oncotarget 8(13): 21892-21902.
  3. Che, H., Yan, Y., Kang, X. H., Guo, F., Yan, M. L., Liu, H. L., Hou, X., Liu, T., Zong, D. K., Sun, L. L., Bao, Y. N., Sun, L. H., Yang, B. F. and Ai, J. (2017). MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion. Mol Neurobiol 54(4): 2595-2610.
  4. Liu, C. D., Wang, Q., Zong, D. K., Pei, S. C., Yan, Y., Yan, M. L., Sun, L. L., Hao, Y. Y., Mao, M., Xing, W. J., Ren, H. and Ai, J. (2016). Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion. Neurobiol Aging 45: 76-87.
  5. Zhang, R., Niu, H., Kang, X., Ban, T., Hong, H. and Ai, J. (2015). Long-Term Administration of Neuropeptide Y in the Subcutaneous Infusion Results in Cardiac Dysfunction and Hypertrophy in Rats. Cell Physiol Biochem 37(1): 94-104.
  6. Sun, L. H., Yan, M. L., Hu, X. L., Peng, L. W., Che, H., Bao, Y. N., Guo, F., Liu, T., Chen, X., Zhang, R., Ban, T., Wang, N., Liu, H. L., Hou, X. and Ai, J. (2015). MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navbeta2 protein coding region in rat with chronic brain hypoperfusion. Mol Neurodegener 10: 36.
  7. Sun, L. H., Ban, T., Liu, C. D., Chen, Q. X., Wang, X., Yan, M. L., Hu, X. L., Su, X. L., Bao, Y. N., Sun, L. L., Zhao, L. J., Pei, S. C., Jiang, X. M., Zong, D. K. and Ai, J. (2015). Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation. J Neurochem 134(6): 1139-1151.
  8. Ma, J. C., Duan, M. J., Sun, L. L., Yan, M. L., Liu, T., Wang, Q., Liu, C. D., Wang, X., Kang, X. H., Pei, S. C., Zong, D. K., Chen, X., Wang, N. and Ai, J. (2015). Cardiac over-expression of microRNA-1 induces impairment of cognition in mice. Neuroscience 299: 66-78.
  9. Wang, N., Sun, L. Y., Zhang, S. C., Wei, R., Xie, F., Liu, J., Yan, Y., Duan, M. J., Sun, L. L., Sun, Y. H., Niu, H. F., Zhang, R. and Ai, J. (2015). MicroRNA-23a participates in estrogen deficiency induced gap junction remodeling of rats by targeting GJA1. Int J Biol Sci 11(4): 390-403.
  10. Liu, H., Li, C., Shen, C., Yin, F., Wang, K., Liu, Y., Zheng, B., Zhang, W., Hou, X., Chen, X., Wu, J., Wang, X., Zhong, C., Zhang, J., Shi, H., Ai, J. and Zhao, S. (2015). MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3. J Neurooncol 122(3): 431-439.
  11. Liu, H., Zhang, W., Wang, K., Wang, X., Yin, F., Li, C., Wang, C., Zhao, B., Zhong, C., Zhang, J., Peng, F., Bi, Y., Shen, C., Hou, X., Zhang, D., Liu, Y., Ai, J. and Zhao, S. (2015). Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy. Toxicol Lett 232(2): 349-355.
  12. Wang, N., Liu, J., Xie, F., Gao, X., Ye, J. H., Sun, L. Y., Wei, R. and Ai, J. (2015). miR-124/ATF-6, a novel lifespan extension pathway of Astragalus polysaccharide in Caenorhabditis elegans. J Cell Biochem 116(2): 242-251.
  13. Sun, L. Y., Wang, N., Ban, T., Sun, Y. H., Han, Y., Sun, L. L., Yan, Y., Kang, X. H., Chen, S., Sun, L. H., Zhang, R., Zhao, Y. J., Zhang, H., Ai, J. and Yang, B. F. (2014). MicroRNA-23a mediates mitochondrial compromise in estrogen deficiency-induced concentric remodeling via targeting PGC-1alpha. J Mol Cell Cardiol 75: 1-11.
  14. Che, H., Sun, L. H., Guo, F., Niu, H. F., Su, X. L., Bao, Y. N., Fu, Z. D., Liu, H. L., Hou, X., Yang, B. F. and Ai, J. (2014). Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat. Cell Physiol Biochem 33(1): 11-22.
  15. Ai, J., Sun, L. H., Che, H., Zhang, R., Zhang, T. Z., Wu, W. C., Su, X. L., Chen, X., Yang, G., Li, K., Wang, N., Ban, T., Bao, Y. N., Guo, F., Niu, H. F., Zhu, Y. L., Zhu, X. Y., Zhao, S. G. and Yang, B. F. (2013). MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. J Neurosci 33(9): 3989-4001.
  16. Xu, L., Yang, B. F. and Ai, J. (2013). MicroRNA transport: a new way in cell communication. J Cell Physiol 228(8): 1713-1719.
  17. Liu, J., Wang, N., Xie, F., Sun, L. H., Chen, Q. X., Ye, J. H., Cai, B. Z., Yang, B. F. and Ai, J. (2013). Blockage of peripheral NPY Y1 and Y2 receptors modulates barorefex sensitivity of diabetic rats. Cell Physiol Biochem 31(2-3): 421-431.
  18. Liu, J., Yang, B. and Ai, J. (2013). Advance in research of microRNA in Caenorhabditis elegans. J Cell Biochem 114(5): 994-1000.
  19. Wang, N., Yang, C., Xie, F., Sun, L., Su, X., Wang, Y., Wei, R., Zhang, R., Li, X., Yang, B. and Ai, J. (2012). Gadd45alpha: a novel diabetes-associated gene potentially linking diabetic cardiomyopathy and baroreflex dysfunction. PLoS One 7(12): e49077.
  20. Zhang, R., Niu, H., Ban, T., Xu, L., Li, Y., Wang, N., Sun, L., Ai, J. and Yang, B. (2013). Elevated plasma microRNA-1 predicts heart failure after acute myocardial infarction. Int J Cardiol 166(1): 259-260.
  21. Ai, J., Zhang, R., Gao, X., Niu, H. F., Wang, N., Xu, Y., Li, Y., Ma, N., Sun, L. H., Pan, Z. W., Li, W. M. and Yang, B. F. (2012). Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly. Cardiovasc Res 95(3): 385-393.
  22. Xie, F., Sun, L., Su, X., Wang, Y., Liu, J., Zhang, R., Wang, N., Zhao, J., Ban, T., Niu, H. and Ai, J. (2012). Neuropeptide Y reverses chronic stress-induced baroreflex hypersensitivity in rats. Cell Physiol Biochem 29(3-4): 463-474.
  23. Zhang, R., Niu, H., Wang, N., Sun, L., Xu, Y., Zhao, R., Ban, X., Yu, Y., Yang, B. and Ai, J. (2012). Daming capsule restores endothelial dysfunction induced by high-fat diet. BMC Complement Altern Med 12: 21.
  24. Xie, F., Zhang, R., Yang, C., Xu, Y., Wang, N., Sun, L., Liu, J., Sun, L., Wei, R. and Ai, J. (2012). Long-term neuropeptide Y administration in the periphery induces abnormal baroreflex sensitivity and obesity in rats. Cell Physiol Biochem 29(1-2): 111-120.
  25. Xie, F., Sun, C., Sun, L. H., Li, J. Y., Chen, X., Che, H., Lu, G. Y., Yang, B. F. and Ai, J. (2011). Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats. Acta Pharmacol Sin 32(3): 321-328.
  26. Ai, J., Wang, L. H., Zhang, R., Qiao, G. F., Wang, N., Sun, L. H., Lu, G. Y., Sun, C. and Yang, B. F. (2010). Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia. BMC Complement Altern Med 10: 80.
  27. Sun, L., Ai, J., Wang, N., Zhang, R., Li, J., Zhang, T., Wu, W., Hang, P., Lu, Y. and Yang, B. (2010). Cerebral ischemia elicits aberration in myocardium contractile function and intracellular calcium handling. Cell Physiol Biochem 26(3): 421-430.
  28. Fardin, N. M., Oyama, L. M. and Campos, R. R. (2012). Changes in baroreflex control of renal sympathetic nerve activity in high-fat-fed rats as a predictor of hypertension. Obesity (Silver Spring) 20(8): 1591-1597.
  29. Lin, M., Ai, J., Harden, S. W., Huang, C., Li, L., Wurster, R. D. and Cheng, Z. J. (2010). Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice. Auton Neurosci 155(1-2): 39-48.
  30. Ai, J., Zhang, R., Li, Y., Pu, J., Lu, Y., Jiao, J., Li, K., Yu, B., Li, Z., Wang, R., Wang, L., Li, Q., Wang, N., Shan, H., Li, Z. and Yang, B. (2010). Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun 391(1): 73-77.
  31. Ai, J., Yan, X., Zhao, L., Lu, Y., Liang, F., Cai, B., Li, G., Lu, Y. and Yang, B. (2009). The protective effect of Daming capsule on heart function in streptozocin-induced diabetic rats with hyperlipidemia. Biol Pharm Bull 32(8): 1354-1358.
  32. Ai, J., Wurster, R. D., Harden, S. W. and Cheng, Z. J. (2009). Vagal afferent innervation and remodeling in the aortic arch of young-adult fischer 344 rats following chronic intermittent hypoxia. Neuroscience 164(2): 658-666.
  33. Jing, A., Li-Mei, Z., Yan-Jie, L., Ben-Zhi, C., Yong, Z. and Bao-Feng, Y. (2009). A randomized, multicentre, open-label, parallel-group trial to compare the efficacy and safety profile of daming capsule in patients with hypercholesterolemia. Phytother Res 23(7): 1039-1042.
  34. Ai, J., Epstein, P. N., Gozal, D., Yang, B., Wurster, R. and Cheng, Z. J. (2007). Morphology and topography of nucleus ambiguus projections to cardiac ganglia in rats and mice. Neuroscience 149(4): 845-860.
  35. Ai, J., Gozal, D., Li, L., Wead, W. B., Chapleau, M. W., Wurster, R., Yang, B., Li, H., Liu, R. and Cheng, Z. (2007). Degeneration of vagal efferent axons and terminals in cardiac ganglia of aged rats. J Comp Neurol 504(1): 74-88.
  36. Ai, J., Gao, H. H., He, S. Z., Wang, L., Luo, D. L. and Yang, B. F. (2001). Effects of matrine, artemisinin, tetrandrine on cytosolic [Ca2+]i in guinea pig ventricular myocytes. Acta Pharmacol Sin 22(6): 512-515.
1 Protocol published
A Rodent Model for Chronic Brain Hypoperfusion Related Diseases: Permanent Bilateral Occlusion of the Common Carotid Arteries (2VO) in Rats
Authors:  Mei-Ling Yan and Jing Ai, date: 01/05/2018, view: 1377, Q&A: 0
Permanent occlusion of bilateral common carotid arteries (2VO) in rat is considered as a suitable animal model to mimic chronic brain hypoperfusion status, which is proved to be a risk factor to precede the Alzheimer’s disease or/and vascular ...