Erin Koffman College of Medicine, University of Toledo
3 protocols

Jianyang Du
  • Biological Sciences, The University of Toledo, US
Research focus
  • Cell biology
  • 3 Author merit


Ph.D in Physiology, Sun Yat-sen University, China, 2006

Current position

Assistant Professor, Biological Sciences, University of Toledo, United States


  1. Du, J., Price, M. P., Taugher, R. J., Grigsby, D., Ash, J. J., Stark, A. C., Hossain Saad, M. Z., Singh, K., Mandal, J., Wemmie, J. A. and Welsh, M. J. (2017). Transient acidosis while retrieving a fear-related memory enhances its lability. Elife 6.
  2. Du, J., Zubayer, H. S. and Mandal, J. (2017). Protons: A neurotransmitter in the brain. Edorium J Cell Biol (3): 1-3.
  3. Yue, Z., Xie, J., Yu, A. S., Stock, J., Du, J. and Yue, L. (2015). Role of TRP channels in the cardiovascular system. Am J Physiol Heart Circ Physiol 308(3): H157-182.
  4. Du, J., Reznikov, L. R. and Welsh, M. J. (2014). Expression and activity of acid-sensing ion channels in the mouse anterior pituitary. PLoS One 9(12): e115310.
  5. Du, J., Reznikov, L. R., Price, M. P., Zha, X. M., Lu, Y., Moninger, T. O., Wemmie, J. A. and Welsh, M. J. (2014). Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proc Natl Acad Sci U S A 111(24): 8961-8966.
  6. Kreple, C. J., Lu, Y., Taugher, R. J., Schwager-Gutman, A. L., Du, J., Stump, M., Wang, Y., Ghobbeh, A., Fan, R., Cosme, C. V., Sowers, L. P., Welsh, M. J., Radley, J. J., LaLumiere, R. T. and Wemmie, J. A. (2014). Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci 17(8): 1083-1091.
  7. Reznikov, L. R., Dong, Q., Chen, J. H., Moninger, T. O., Park, J. M., Zhang, Y., Du, J., Hildebrand, M. S., Smith, R. J., Randak, C. O., Stoltz, D. A. and Welsh, M. J. (2013). CFTR-deficient pigs display peripheral nervous system defects at birth. Proc Natl Acad Sci U S A 110(8): 3083-3088.
  8. Vralsted, V. C., Price, M. P., Du, J., Schnizler, M., Wunsch, A. M., Ziemann, A. E., Welsh, M. J. and Wemmie, J. A. (2011). Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Genes Brain Behav 10(4): 444-450.
  9. Zuo, W. L., Du, J. Y., Huang, J. H., Li, S., Zhang, G., Chen, S. L., Ruan, Y. C., Cheng, C. H. and Zhou, W. L. (2011). Tyrosine phosphorylation modulates store-operated calcium entry in cultured rat epididymal basal cells. J Cell Physiol 226(4): 1069-1073.
  10. Xie, J., Sun, B., Du, J., Yang, W., Chen, H. C., Overton, J. D., Runnels, L. W. and Yue, L. (2011). Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Sci Rep 1: 146.
  11. Du, J., Xie, J., Zhang, Z., Tsujikawa, H., Fusco, D., Silverman, D., Liang, B. and Yue, L. (2010). TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res 106(5): 992-1003.
  12. Du, J., Xie, J. and Yue, L. (2009). Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc Natl Acad Sci U S A 106(17): 7239-7244.
  13. Du, J., Xie, J. and Yue, L. (2009). Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J Gen Physiol 134(6): 471-488.
  14. Heeringa, S. F., Moller, C. C., Du, J., Yue, L., Hinkes, B., Chernin, G., Vlangos, C. N., Hoyer, P. F., Reiser, J. and Hildebrandt, F. (2009). A novel TRPC6 mutation that causes childhood FSGS. PLoS One 4(11): e7771.
  15. Xiang, H., Wang, L., Cui, J., Du, J., Wang, K. and Xu, A. (2009). Effects of recombinant neurotoxins on single Na(+) channels in isolated rat hippocampal neurons. J Biochem Mol Toxicol 23(4): 244-255.
  16. Du, J. Y., Zuo, W. L., Ruan, Y. C., Yang, Z. H., Chen, M. H., Chen, S. L., Li, S., Wu, Z. L., Xiang, H. and Zhou, W. L. (2009). Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture. Biol Reprod 80(1): 13-23.
  17. Ruan, Y. C., Wang, Z., Du, J. Y., Zuo, W. L., Guo, J. H., Zhang, J., Wu, Z. L., Wong, H. Y., Chung, Y. W., Chan, H. C. and Zhou, W. L. (2008). Regulation of smooth muscle contractility by the epithelium in rat vas deferens: role of ATP-induced release of PGE2. J Physiol 586(20): 4843-4857.
  18. Chen, M., Du, J., Jiang, W., Zuo, W., Wang, F., Li, M., Chan, H. and Zhou, W. (2008). Functional expression of cystic fibrosis transmembrane conductance regulator in rat oviduct epithelium. Acta Biochim Biophys Sin (Shanghai) 40(10): 864-872.
  19. Yang, Z. H., Yu, H. J., Pan, A., Du, J. Y., Ruan, Y. C., Ko, W. H., Chan, H. C. and Zhou, W. L. (2008). Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model. PLoS One 3(10): e3348.
  20. Zhou, W. L., Zuo, W. L., Ruan, Y. C., Wang, Z., Du, J. Y., Xiong, Y. and Chan, H. C. (2007). The role of extracellular ATP in the male reproductive tract. Sheng Li Xue Bao 59(4): 487-494.
  21. Zhang, L., Tang, S. B., Xiang, H., Du, J. Y., Huang, B., Luo, Y. and Chen, X. G. (2007). Effect of supernatant fluid of retinal cells on dynamics of sodium ion channels of neuron-like cells derived from embryonic stem cells. Chin J Ocul Fundus Dis 23: 91-93.
  22. Li, M., Du, J., Jiang, J., Ratzan, W., Su, L. T., Runnels, L. W. and Yue, L. (2007). Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7. J Biol Chem 282(35): 25817-25830.
  23. Zhong, X. F., Li, Y. P., Ge, J., Huang, B., Peng, F. H., Du, J. Y., Lin, J. X., Wu, Z. L. and Liu, J. B. (2006). Isolation and culture of tumor stem cells in human retinoblastomas. Chinese Journal of pathophysiology 22(6): 1177-1181.
  24. Du, J. Y., Ruan, Y. C., Zuo, W. L., Yang, Z. H., Chen, M. H., Wu, Z. L., Xiang, H. and Zhou, W. L. (2006). Cellular mechanisms of carbachol-stimulated Cl- secretion in rat epididymal epithelium. Biol Reprod 75(3): 407-413.
  25. Du, J. Y., Zuo, W. L., Chen, M. H., Xiang, H. and Zhou, W. L. (2006). Involvement of muscarinic acetylcholine receptors in chloride secretion by cultured rat epididymal epithelium. Cell Biol Int 30(9): 741-746.
  26. Ou, J., Wang, L., Ding, X., Du, J., Zhang, Y., Chen, H. and Xu, A. (2004). Stationary phase protein overproduction is a fundamental capability of Escherichia coli. Biochem Biophys Res Commun 314(1): 174-180.
  27. Wang, L., Ou, J., Peng, L., Zhong, X., Du, J., Liu, Y., Huang, Y., Liu, W., Zhang, Y., Dong, M. and Xu, A. L. (2004). Functional expression and characterization of four novel neurotoxins from sea anemone Anthopleura sp. Biochem Biophys Res Commun 313(1): 163-170.
3 Protocols published
Combinations of Patch-Clamp and Confocal Calcium Imaging in Acutely Isolated Adult Mouse Amygdala Brain Slices
Authors:  Erin E. Koffman and Jianyang Du, date: 08/05/2018, view: 4852, Q&A: 0
Calcium imaging is a powerful technique in the study of neuronal physiology, as it avoids the enzyme treatment on neurons and is able to study the neuronal activities in vivo. Using calcium-imaging techniques, we are able to monitor the ...
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