Mien-Chie Hung Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, USA
2 protocols

Hsin-Wei Liao
  • Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, USA
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D, UT MD Anderson Cancer Center, United States, 2015

Current position

Postdoc Fellow, Center of Systems Biology, MGH and Harvard University, United States


  1. Liao, H. W., Hsu, J. M., Xia, W., Wang, H. L., Wang, Y. N., Chang, W. C., Arold, S. T., Chou, C. K., Tsou, P. H., Yamaguchi, H., Fang, Y. F., Lee, H. J., Lee, H. H., Tai, S. K., Yang, M. H., Morelli, M. P., Sen, M., Ladbury, J. E., Chen, C. H., Grandis, J. R., Kopetz, S. and Hung, M. C. (2015). PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest 125(12): 4529-4543.
  2. Wang, Y., Hsu, J. M., Kang, Y., Wei, Y., Lee, P. C., Chang, S. J., Hsu, Y. H., Hsu, J. L., Wang, H. L., Chang, W. C., Li, C. W., Liao, H. W., Chang, S. S., Xia, W., Ko, H. W., Chou, C. K., Fleming, J. B., Wang, H., Hwang, R. F., Chen, Y., Qin, J. and Hung, M. C. (2016). Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Res 76(23): 7049-7058.
  3. Ko, H. W., Lee, H. H., Huo, L., Xia, W., Yang, C. C., Hsu, J. L., Li, L. Y., Lai, C. C., Chan, L. C., Cheng, C. C., Labaff, A. M., Liao, H. W., Lim, S. O., Li, C. W., Wei, Y., Nie, L., Yamaguchi, H. and Hung, M. C. (2016). GSK3beta inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget 7(35): 57131-57144.
  4. Hsu, M. C., Hung, W. C., Yamaguchi, H., Lim, S. O., Liao, H. W., Tsai, C. H. and Hung, M. C. (2016). Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. Am J Cancer Res 6(3): 628-638.
  5. Lee, H. J., Lan, L., Peng, G., Chang, W. C., Hsu, M. C., Wang, Y. N., Cheng, C. C., Wei, L., Nakajima, S., Chang, S. S., Liao, H. W., Chen, C. H., Lavin, M., Ang, K. K., Lin, S. Y. and Hung, M. C. (2015). Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25(2): 225-236.
  6. Chou, R. H., Wang, Y. N., Hsieh, Y. H., Li, L. Y., Xia, W., Chang, W. C., Chang, L. C., Cheng, C. C., Lai, C. C., Hsu, J. L., Chang, W. J., Chiang, S. Y., Lee, H. J., Liao, H. W., Chuang, P. H., Chen, H. Y., Wang, H. L., Kuo, S. C., Chen, C. H., Yu, Y. L. and Hung, M. C. (2014). EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell 30(2): 224-237.
  7. Hsu, J. M., Chen, C. T., Chou, C. K., Kuo, H. P., Li, L. Y., Lin, C. Y., Lee, H. J., Wang, Y. N., Liu, M., Liao, H. W., Shi, B., Lai, C. C., Bedford, M. T., Tsai, C. H. and Hung, M. C. (2011). Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol 13(2): 174-181.
  8. Wu, C. C., Liu, M. T., Chang, Y. T., Fang, C. Y., Chou, S. P., Liao, H. W., Kuo, K. L., Hsu, S. L., Chen, Y. R., Wang, P. W., Chen, Y. L., Chuang, H. Y., Lee, C. H., Chen, M., Wayne Chang, W. S. and Chen, J. Y. (2010). Epstein-Barr virus DNase (BGLF5) induces genomic instability in human epithelial cells. Nucleic Acids Res 38(6): 1932-1949.
  9. Huang, Y. J., Liao, H. W., Wu, C. C. and Peng, H. L. (2009). MrkF is a component of type 3 fimbriae in Klebsiella pneumoniae. Res Microbiol 160(1): 71-79.
1 Protocol published
Authors:  Hsin-Wei Liao and Mien-Chie Hung, date: 06/05/2017, view: 10526, Q&A: 1
The host microenvironment plays a prominent role in tumor growth, angiogenesis, invasion, metastasis, and response to therapy. Orthotopic tumor model mimics the natural environment of tumor development and provides an effective approach to ...
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